{"id":6460,"date":"2026-10-19T09:48:56","date_gmt":"2026-10-19T09:48:56","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-olafur-palsson\/"},"modified":"2026-10-19T09:48:56","modified_gmt":"2026-10-19T09:48:56","slug":"doktorsvorn-i-laeknavisindum-olafur-palsson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-olafur-palsson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – \u00d3lafur P\u00e1lsson"},"content":{"rendered":"
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F\u00f6studaginn 13. febr\u00faar ver \u00d3lafur P\u00e1lsson doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands og L\u00e6knadeild Lundarh\u00e1sk\u00f3la. Ritger\u00f0in ber heiti\u00f0: A\u00f0 kanna bili\u00f0 milli ranns\u00f3kna og raunveruleika \u00ed s\u00f3ragigt. Exploring the Gap Between Clinical Trials and Real-World Practice in Psoriatic Arthritis.<\/p>\n

Andm\u00e6lendur eru Vinod Chandran pr\u00f3fessor, d\u00f3sent vi\u00f0 University of Toronto, og dr. J\u00f3nas A\u00f0alsteinn A\u00f0alsteinsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00cd.<\/p>\n

Umsj\u00f3narkennari og lei\u00f0beinandi var Bj\u00f6rn Gu\u00f0bj\u00f6rnsson, pr\u00f3fessor emeritus, og me\u00f0lei\u00f0beinandi \u00deorvar\u00f0ur J\u00f3n L\u00f6ve, pr\u00f3fessor. Umsj\u00f3narkennari og lei\u00f0beinandi vi\u00f0 Lundarh\u00e1sk\u00f3la var Meliha C. Kapetanovic, me\u00f0pr\u00f3fessor (s. adjungerad professor) og me\u00f0lei\u00f0beinendur voru J\u00f3n \u00deorkell Einarsson yfirl\u00e6knir og Johan K. Wallman s\u00e9rfr\u00e6\u00f0ingur. S\u00e1tu lei\u00f0beinendur vi\u00f0 Lundarh\u00e1sk\u00f3la einnig \u00ed doktorsnefnd vi\u00f0 H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

S\u00e6d\u00eds S\u00e6varsd\u00f3ttir, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0arsal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 09.00.<\/p>\n

V\u00f6rninni ver\u00f0ur streymt:\u00a0<\/p>\n

https:\/\/vimeo.com\/event\/5724210<\/a><\/p>\n

\u00c1grip<\/strong><\/p>\n

S\u00f3ragigt er langvinnur b\u00f3lgusj\u00fakd\u00f3mur \u00ed li\u00f0um tengdur h\u00fa\u00f0sj\u00fakd\u00f3mnum psoriasis. Hann getur haft dj\u00fapar og langvarandi aflei\u00f0ingar, b\u00e6\u00f0i fyrir sj\u00faklinga sem \u00fej\u00e1st af honum og fyrir samf\u00e9lagi\u00f0. Eftirlit og me\u00f0fer\u00f0 s\u00f3ragigtar er afar fj\u00f6l\u00fe\u00e6tt og getur \u00fearfnast \u00feverfaglegs samstarfs.<\/p>\n

Me\u00f0fer\u00f0arlei\u00f0beiningar vi\u00f0 s\u00f3ragigt byggja a\u00f0 miklu leyti \u00e1 ni\u00f0urst\u00f6\u00f0um slembira\u00f0a\u00f0ra tv\u00edblindra ranns\u00f3kna, en vi\u00f0 vitum a\u00f0 einungis um \u00feri\u00f0jungur sj\u00faklinga uppfyllir innt\u00f6kuskilyr\u00f0in \u00ed ranns\u00f3knirnar, oft vegna aldurs e\u00f0a of l\u00edtillar sj\u00fakd\u00f3msvirkni vi\u00f0 innt\u00f6ku. \u00cd fyrstu greininni er s\u00fdnt fram \u00e1 a\u00f0 sj\u00faklingar me\u00f0 s\u00f3ragigt sem uppfylla ekki innt\u00f6kuskilyr\u00f0i slembira\u00f0a\u00f0ra ranns\u00f3kna \u00e1 l\u00edft\u00e6knilyfjum f\u00e1 jafnmikinn \u00e1vinning af sl\u00edkum lyfjum og halda \u00e1fram notkun \u00feeirra \u00ed sama m\u00e6li eins og \u00feeir sem uppfylla innt\u00f6kuskilyr\u00f0in.<\/p>\n

Einn \u00fe\u00e1ttur me\u00f0fer\u00f0ar vi\u00f0 s\u00f3ragigt er a\u00f0 stilla langvinna li\u00f0verki. B\u00f3lguey\u00f0andi gigtarlyf eru hornsteinn verkjame\u00f0fer\u00f0ar s\u00f3ragigtar en af \u00feeim er h\u00e6gt a\u00f0 f\u00e1 aukaverkanir sem geta jafnvel veri\u00f0 alvarlegar. \u00cd annarri greininni er s\u00fdnt fram \u00e1 a\u00f0 vi\u00f0 upphaf l\u00edft\u00e6knilyfjame\u00f0fer\u00f0ar me\u00f0 TNF hemlum minnkar notkunin \u00e1 b\u00f3lguey\u00f0andi gigtarlyfjum um 40-50%. \u00deetta gefur til kynna \u00f3beinan \u00f6ryggis\u00e1vinning af \u00fev\u00ed a\u00f0 hefja sl\u00edka me\u00f0fer\u00f0.<\/p>\n

Markmi\u00f0 me\u00f0fer\u00f0ar vi\u00f0 s\u00f3ragigt er a\u00f0 upphefja \u00f6ll einkenni og teikn um sj\u00fakd\u00f3minn ef \u00fea\u00f0 er h\u00e6gt, me\u00f0 \u00f6\u00f0rum or\u00f0um a\u00f0 koma sj\u00faklingum \u00ed sj\u00fakd\u00f3mshl\u00e9, helst \u00e1n nokkurra aukaverkana me\u00f0fer\u00f0ar. A\u00f0 n\u00e1 og vi\u00f0halda sj\u00fakd\u00f3mshl\u00e9i yfir lengri t\u00edma, svok\u00f6llu\u00f0u vi\u00f0varandi sj\u00fakd\u00f3mshl\u00e9i, hefur s\u00fdnt sig b\u00e6ta langt\u00edmahorfur \u00ed ikts\u00fdki \u00ed gegnum aukna l\u00edkamlega hreysti, betri l\u00edfsg\u00e6\u00f0i og minni \u00fer\u00f3un li\u00f0skemmda. \u00c1hrif vi\u00f0varandi sj\u00fakd\u00f3mshl\u00e9s hefur hinga\u00f0 til ekki veri\u00f0 miki\u00f0 rannsaka\u00f0 \u00ed s\u00f3ragigt. \u00cd \u00feri\u00f0ju og fj\u00f3r\u00f0u greininni er sko\u00f0u\u00f0 t\u00ed\u00f0ni vi\u00f0varandi sj\u00fakd\u00f3mshl\u00e9s og forsp\u00e1r\u00fe\u00e6ttir fyrir \u00fev\u00ed b\u00e6\u00f0i \u00ed Sv\u00ed\u00fej\u00f3\u00f0 og \u00e1 \u00cdslandi. \u00der\u00e1tt fyrir gott a\u00f0gengi a\u00f0 lyfjame\u00f0fer\u00f0um upplifir helmingur sj\u00faklinga aldrei sj\u00fakd\u00f3mshl\u00e9 og f\u00e6rri en \u00feri\u00f0jungur \u00feeirra f\u00e1 vi\u00f0varandi sj\u00fakd\u00f3mshl\u00e9. Karlkyn og minni \u00fereyta vi\u00f0 upphaf me\u00f0fer\u00f0ar sp\u00e1 fyrir betri l\u00edkum \u00e1 a\u00f0 n\u00e1 vi\u00f0varandi sj\u00fakd\u00f3mshl\u00e9i.<\/p>\n

Abstract<\/strong><\/p>\n

Psoriatic arthritis is a chronic, potentially disabling inflammatory joint disorder associated with psoriatic skin disease. The burden of psoriatic arthritis is often substantial and long-lasting, both for patients and for society. The treatment and follow-up of patients with psoriatic arthritis is multifaceted and may require multidisciplinary collaboration.<\/p>\n

Most management guidelines rely heavily on results from randomised controlled pharmaceutical trials, yet only about a third of patients would be eligible to participate in these studies, which may limit their external validity. In Study I, we demonstrate that patients who would not have been eligible for clinical trials for biologic disease-modifying anti-rheumatic drugs (bDMARDs) still experience comparable clinical benefits and have similar drug survival as patients who would have met the trial criteria.<\/p>\n

Managing chronic joint pain is an important component of care in psoriatic arthritis. Non-steroidal anti-inflammatory drugs are frequently used for pain control, although they may have potentially severe side-effects. In Study II, we demonstrate that patients initiating TNF inhibitors reduce their NSAID consumption by 40-50%, highlighting an indirect safety benefit of introducing bDMARD therapy.<\/p>\n

The optimal treatment goal in psoriatic arthritis is the resolution of all signs and symptoms of disease, a state called remission, without adverse treatment effects. Reaching and maintaining remission for longer periods of time, termed sustained remission, has been shown in rheumatoid arthritis to improve long-term outcomes through better physical function, quality of life and less radiographic progression. Sustained remission has not been extensively studied in psoriatic arthritis. In Studies III and IV, we investigate the prevalence and predictors of sustained remission in Sweden and Iceland. Despite access to advanced therapies, fewer than half of all patients ever achieved a state of remission during follow-up, and fewer than one third of patients ever achieved sustained remission. Male sex and lower patient reported fatigue at the start of the first bDMARD therapy predicted a greater likelihood of sustained remission.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

\u00d3lafur P\u00e1lsson er f\u00e6ddur 1986 \u00ed Reykjav\u00edk. Hann lauk st\u00fadentspr\u00f3fi fr\u00e1 n\u00e1tt\u00farufr\u00e6\u00f0ideild Menntask\u00f3lans \u00ed Reykjav\u00edk og s\u00ed\u00f0an cand. med. et kir. \u00ed l\u00e6knisfr\u00e6\u00f0i 2014. A\u00f0 loknu kand\u00eddats\u00e1ri starfa\u00f0i \u00d3lafur sem s\u00e9rn\u00e1msl\u00e6knir \u00ed lyfl\u00e6kningum og lauk kjarnan\u00e1mi \u00ed lyfl\u00e6kningum (Core Medical Training) vi\u00f0 Landsp\u00edtala og var\u00f0 me\u00f0limur Royal College of Physicans (MRCP). Hann h\u00e9lt til Lundar \u00ed Sv\u00ed\u00fej\u00f3\u00f0 og lauk s\u00e9rn\u00e1mi \u00ed gigtarl\u00e6kningum vi\u00f0 Lundarh\u00e1sk\u00f3la 2022. \u00d3lafur sneri heim sama \u00e1r og hefur s\u00ed\u00f0an starfa\u00f0 \u00e1 Landsp\u00edtala og \u00e1 Gigtarmi\u00f0st\u00f6\u00f0inni sem gigtarl\u00e6knir en stunda\u00f0 kennslu l\u00e6knanema vi\u00f0 H\u00e1sk\u00f3la \u00cdslands. Foreldrar \u00d3lafs eru P\u00e1ll \u00d3lafsson e\u00f0lisverkfr\u00e6\u00f0ingur og El\u00ednborg Gu\u00f0mundsd\u00f3ttir augnl\u00e6knir. Eiginkona \u00d3lafs er \u00de\u00f3runn Eva Gu\u00f0nad\u00f3ttir snyrtifr\u00e6\u00f0ingur og \u00feroska\u00fej\u00e1lfi. B\u00f6rn \u00d3lafs eru Lilja Bj\u00f6rg, S\u00f3ley Harpa og Rakel D\u00f6gg.<\/p>\n<\/div><\/div>","protected":false},"featured_media":5878,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2026-02-13T09:00:00+00:00","_phd_date_end":"2026-02-13T12:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"A\u00f0 kanna bili\u00f0 milli ranns\u00f3kna og raunveruleika \u00ed s\u00f3ragigt. 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