{"id":6455,"date":"2026-10-19T09:48:55","date_gmt":"2026-10-19T09:48:55","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lifefnafraedi-mahtab-hafizi-yazdabadi\/"},"modified":"2026-10-19T09:48:55","modified_gmt":"2026-10-19T09:48:55","slug":"doktorsvorn-i-lifefnafraedi-mahtab-hafizi-yazdabadi","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lifefnafraedi-mahtab-hafizi-yazdabadi\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edfefnafr\u00e6\u00f0i &#8211; Mahtab Hafizi Yazdabadi"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p><strong>Doktorsefni:<\/strong> Mahtab Hafizi Yazdabadi<\/p>\n<p><strong>Heiti ritger\u00f0ar: <\/strong>Sameindaleg virkni \u00f3m\u00f3ta\u00f0a umritunar\u00fe\u00e1ttarins HMGA1 ranns\u00f6ku\u00f0 me\u00f0 staksameindat\u00e6kni (The Intrinsically Disordered HMGA1 Protein Investigated with Single-molecule Techniques).<\/p>\n<p><strong>Andm\u00e6lendur<\/strong>: Dr. Margr\u00e9t Helga \u00d6gmundsd\u00f3ttir, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands.<br \/>Dr. Louise Pinet, lektor, CRMN-ENS Lyon, Frakklandi.<\/p>\n<p><strong>Lei\u00f0beinandi: <\/strong>Dr. P\u00e9tur O. Hei\u00f0arsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n<p><strong>Einnig \u00ed doktorsnefnd: <br \/> <\/strong>Dr. Zophon\u00edas J\u00f3nsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<br \/> Dr. Dominika Gruszka, d\u00f3sent vi\u00f0 E\u00f0lisfr\u00e6\u00f0ideild Oxford H\u00e1sk\u00f3la og Kavli Institute for Nanoscience Discovery.<\/p>\n<p><strong>Doktorsv\u00f6rn st\u00fdrir:<\/strong> Dr. Sn\u00e6bj\u00f6rn P\u00e1lsson, pr\u00f3fessor og deildarforseti\u00a0L\u00edf- og umhverfisv\u00edsindadeildar H\u00cd.<\/p>\n<p><strong>\u00c1grip<\/strong><\/p>\n<p>Samskipti milli kjarnapr\u00f3teina og DNA eru grundvallaratri\u00f0i \u00ed mikilv\u00e6gum frumuferlum, og \u00fev\u00ed er byggingarlegur sveigjanleiki einn af einkennandi \u00fe\u00e1ttum margra DNA-bindipr\u00f3teina. M\u00f6rg \u00feessara pr\u00f3teina, \u00fear \u00e1 me\u00f0al umritunar\u00fe\u00e6ttir og litnism\u00f3tandi pr\u00f3tein, innihalda sv\u00e6\u00f0i sem eru \u00f3m\u00f3tu\u00f0. High-mobility group pr\u00f3teini\u00f0 HMGA1 er mj\u00f6g \u00f3m\u00f3ta\u00f0 litnism\u00f3tandi pr\u00f3tein sem er miki\u00f0 tj\u00e1\u00f0 \u00ed stofnfrumum og \u00ed \u00e1gengum krabbameinum, sem gerir \u00fea\u00f0 a\u00f0 hugsanlegu me\u00f0fer\u00f0arskotmarki . HMGA1 endurm\u00f3tar litni me\u00f0 \u00fev\u00ed a\u00f0 keppa vi\u00f0 tengipr\u00f3teini\u00f0 hist\u00f3n H1, en sameindal\u00edffr\u00e6\u00f0ilegur ferill \u00feessarar samkeppni er enn \u00f3\u00feekktur vegna \u00e1skorana vi\u00f0 ranns\u00f3knir \u00e1 \u00f3m\u00f3tu\u00f0um pr\u00f3teinum. \u00cd \u00feessari ranns\u00f3kn beittum vi\u00f0 staksameindat\u00e6kni til a\u00f0 kanna sameindalegan grundv\u00f6ll starfsemi HMGA1 og \u00e1hrif \u00feess \u00e1 byggingu litnisagna, einkum me\u00f0 tilliti til \u00feess hvernig \u00fea\u00f0 hefur \u00e1hrif \u00e1 bindingu hist\u00f3ns H1. Ni\u00f0urst\u00f6\u00f0ur okkar s\u00fdna a\u00f0 HMGA1a breytir ekki markt\u00e6kt afbindingart\u00ed\u00f0ni H1, sem bendir til \u00feess a\u00f0 \u00fea\u00f0 geti ekki fjarl\u00e6gt H1 \u00far litnis\u00f6gnum \u00e1 virkan h\u00e1tt. Hins vegar dregur HMGA1a \u00far bindingarhra\u00f0a H1, sem bendir til a\u00f0 \u00feegar H1 losnar, komi HMGA1a l\u00edklega \u00ed veg fyrir endurbindingu \u00feess. A\u00f0 auki framkv\u00e6mdum vi\u00f0 frumranns\u00f3knir me\u00f0 staksameindat\u00e6kni \u00e1 styttu HMGA1a-afbrig\u00f0i sem vantar s\u00faran C-enda, og veita \u00fe\u00e6r fyrstu inns\u00fdn \u00ed m\u00f6gulegt stj\u00f3rnhlutverk \u00feessa dularfulla sv\u00e6\u00f0is. A\u00f0 lokum uppg\u00f6tvu\u00f0um vi\u00f0 a\u00f0 H1 getur bundist litnis\u00f6gnum sem eru a\u00f0 hluta opnar, me\u00f0 mun h\u00e6rri afbindingart\u00ed\u00f0ni . Me\u00f0 \u00fev\u00ed a\u00f0 n\u00fdta h\u00e1\u00fer\u00f3a\u00f0ar staksameindaa\u00f0fer\u00f0ir varpa \u00feessar ranns\u00f3knir lj\u00f3si \u00e1 sameindalega virkni HMGA1-mi\u00f0la\u00f0rar litnisendurstillingar og leggja grunn a\u00f0 frekari ranns\u00f3knum sem mi\u00f0a a\u00f0 \u00fev\u00ed a\u00f0 sko\u00f0a HMGA-pr\u00f3tein sem \u00e6xlisvaldandi st\u00fdri\u00fe\u00e6tti \u00ed krabbameini.<\/p>\n<p>\u00a0<\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>Mahtab Hafizi f\u00e6ddist \u00e1ri\u00f0 1994 \u00ed Esfahan, \u00cdran. H\u00fan lauk BS-pr\u00f3fi \u00ed frumu- og sameindal\u00edffr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3lanum \u00ed Shiraz \u00e1ri\u00f0 2016 og MS-pr\u00f3fi \u00ed l\u00edfefnafr\u00e6\u00f0i fr\u00e1 sama h\u00e1sk\u00f3la \u00e1ri\u00f0 2019. \u00c1ri\u00f0 2020 h\u00f3f h\u00fan st\u00f6rf sem ranns\u00f3knara\u00f0sto\u00f0arma\u00f0ur \u00ed ranns\u00f3knarh\u00f3pi Dr. P\u00e9turs O. Hei\u00f0arssonar \u00fear sem h\u00fan h\u00f3f ranns\u00f3knir \u00e1 \u00f3m\u00f3ta\u00f0u\u00f0um umritunar\u00fe\u00e1ttum. H\u00fan h\u00f3f doktorsn\u00e1m \u00ed l\u00edfefnafr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2021 og sinnir n\u00fa \u00e1fram ranns\u00f3knum \u00e1 \u00feessu svi\u00f0i.<\/p>\n<\/div><\/div>","protected":false},"featured_media":5873,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2025-12-19T13:00:00+00:00","_phd_date_end":"2025-12-19T15:00:00+00:00","_phd_location":"Askja Stofa 132","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Sameindaleg virkni \u00f3m\u00f3ta\u00f0a umritunar\u00fe\u00e1ttarins HMGA1 ranns\u00f6ku\u00f0 me\u00f0 staksameindat\u00e6kni (The Intrinsically Disordered HMGA1 Protein Investigated with Single-molecule Techniques)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_lifefnafraedi_mahtab_hafizi_yazdabadi","_phd_source_node_id":"442987","_phd_source_type":"vidburdir","_phd_member_id":997,"footnotes":""},"phd_school":[96,93],"phd_discipline":[106],"class_list":["post-6455","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-lif-og-umhverfisvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-lifefnafraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6455","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6455\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/5873"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6455"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6455"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6455"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}