{"id":6439,"date":"2026-10-19T09:48:54","date_gmt":"2026-10-19T09:48:54","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-efnafraedi-sreejith-sudhakaran-jayabhavan\/"},"modified":"2026-10-19T09:48:54","modified_gmt":"2026-10-19T09:48:54","slug":"doktorsvorn-i-efnafraedi-sreejith-sudhakaran-jayabhavan","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-efnafraedi-sreejith-sudhakaran-jayabhavan\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed efnafr\u00e6\u00f0i – Sreejith Sudhakaran Jayabhavan"},"content":{"rendered":"
\n
\n

Doktorsefni:
<\/strong>Sreejith Sudhakaran Jayabhavan<\/p>\n

Heiti ritger\u00f0ar:
<\/strong>Efnasm\u00ed\u00f0i snjallefna \u00ed gelum me\u00f0 l\u00e1gan sameindamassa\u00a0<\/p>\n

Andm\u00e6lendur<\/strong>:
Dr. Gareth O. Lloyd, d\u00f3sent vi\u00f0 N\u00e1tt\u00faruv\u00edsindasvi\u00f0, H\u00e1sk\u00f3linn \u00ed Lincoln, Englandi
Dr. Stef\u00e1n J\u00f3nsson, Yfirma\u00f0ur ARD e\u00f0lisefnafr\u00e6\u00f0ilegra a\u00f0fer\u00f0a hj\u00e1 Alvotech, \u00cdslandi<\/p>\n

Lei\u00f0beinandi:
<\/strong>Dr. Krishna Kumar Damodaran, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Einnig \u00ed doktorsnefnd:
<\/strong>Dr. M\u00e1r M\u00e1sson, pr\u00f3fessor vi\u00f0 Lyfjav\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands
Dr. Gu\u00f0mundur Gunnar Haraldsson, pr\u00f3fessor emeritus vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Doktorsv\u00f6rn st\u00fdrir:
<\/strong>Dr. Birgir Hrafnkelsson, pr\u00f3fessor og deildarforseti Raunv\u00edsindadeildar H\u00cd\u00a0\u00a0\u00a0<\/p>\n

\u00c1grip:
<\/strong>N\u00e1tt\u00faran s\u00fdnir \u00ed e\u00f0li s\u00ednu \u00f3tr\u00falega h\u00e6fileika til a\u00f0 ra\u00f0a, setja e\u00f0a hvarfa sj\u00e1lfkrafa saman grunneiningar til a\u00f0 mynda sm\u00e1sameindir, fj\u00f6lli\u00f0ur svo og risasameindir. Ranns\u00f3knir og \u00feekking \u00e1 n\u00e1tt\u00farulegum ferlum \u00ed sj\u00e1lfkrafa hv\u00f6rfum grunneininga til fj\u00f6lli\u00f0umyndunar er krefjandi og heillandi vi\u00f0fangsefni, s\u00e9r \u00ed lagi \u00fear sem l\u00edfheimurinn hannar og b\u00fdr til \u201esnjallefni\u201c \u00e1 einfaldan h\u00e1tt. \u00cd \u00feessu ranns\u00f3knaverkefni til doktorspr\u00f3fs voru ranns\u00f6ku\u00f0 gel efnasamb\u00f6nd me\u00f0 l\u00e1ga sameindamassa (LMWG). Hlutverk \u00fdmissa \u00f3tengdra \u00fe\u00e1tta og v\u00edxlverkana milli virkra efnah\u00f3pa voru rannsaka\u00f0ir me\u00f0 \u00fea\u00f0 markmi\u00f0 a\u00f0 \u00e1kvar\u00f0a hva\u00f0a \u00fe\u00e6ttir stj\u00f3rna sj\u00e1lfkrafa byggingu sameindanna \u00ed gelunum. Valin voru fj\u00f6l\u00fe\u00e1tta kerfi me\u00f0 tveimur virkum h\u00f3pum og a\u00f0allega liti\u00f0 til virkni eftirfarandi h\u00f3pa: am\u00ed\u00f0, \u00fevagefni, th\u00edo\u00fevagefni og karbamat vegna eiginleika virku h\u00f3panna og h\u00e6fileika til a\u00f0 mynda vetnistengi \u00ed trefjakenndum gelum. \u00c1hrif efna eins og salta\/j\u00f3na, bakter\u00edudrepandi efna og l\u00edfr\u00e6nna lyfjaefna voru einnig ranns\u00f6ku\u00f0 me\u00f0 tilliti til bakter\u00edudrepandi virkni, gelmyndunar, og breytinga \u00e1 krist\u00f6llun trefjanna \u00ed gelforminu. Mismunandi LMWG gel voru h\u00f6nnu\u00f0 og sm\u00ed\u00f0u\u00f0 og uppbygging e\u00f0a byggingaeiginleikar \u00feessara gela ranns\u00f6ku\u00f0 og greind me\u00f0 tog\u00feolsm\u00e6lingum, seigju, og styrkleika gelsins, rafeindasm\u00e1sj\u00e1, lj\u00f3sbrotseiginleikum, FT-IR, litr\u00f3fsm\u00e6lingum \u00e1 \u00fatfj\u00f3lubl\u00e1a og s\u00fdnilega svi\u00f0inu og r\u00f6ntgen kristal greiningu. \u00c1hrif m\u00e1lmsalta \u00e1 gelin voru ranns\u00f6ku\u00f0, b\u00e6\u00f0i vi\u00f0 myndun \u00feeirra og ni\u00f0urbrot. V\u00edxlverkun l\u00edfvirkra efna og efna er l\u00edkja eftir lyfjavirkum sameindum var ranns\u00f6ku\u00f0 til a\u00f0 \u00f6\u00f0last skilning \u00e1 hlutverki virku h\u00f3panna vi\u00f0 krist\u00f6llun lyfvirkra efna (API). Hlutverk og \u00e1hrif handhverfuhreinna efna vi\u00f0 sj\u00e1lfvirka byggingu fj\u00f6l\u00fe\u00e1tta kerfa vi\u00f0 gelmyndun var ranns\u00f6ku\u00f0 og greind. S\u00e9rt\u00e6k samsetning \u00ed bl\u00f6ndum af handhverfu gelunum var sta\u00f0fest me\u00f0 \u00fdmsum greiningara\u00f0fer\u00f0um svo og afgerandi hlutverk tiltekinna virkra h\u00f3pa til a\u00f0 st\u00fdra byggingareiginleikum \u00feessara gela. Ranns\u00f3knaverkefni\u00f0 svara\u00f0i \u00fdmsum spurningum var\u00f0andi gelmyndun og getur leitt til betri og skilvirkari a\u00f0fer\u00f0afr\u00e6\u00f0i vi\u00f0 h\u00f6nnun og myndun LMWG me\u00f0 fyrirsj\u00e1anlega eiginleika.<\/p>\n

Um doktorsefni\u00f0:
<\/strong>Sreejith er f\u00e6ddur \u00e1 Indlandi 1996. \u00c1huga sinn \u00e1 efnafr\u00e6\u00f0i \u00feakkar hann m\u00f3\u00f0ur sinni sem er menntask\u00f3lakennari \u00ed efnafr\u00e6\u00f0i \u00e1 Indlandi og sem hvatti hann til n\u00e1ms \u00ed efnafr\u00e6\u00f0i. Hann lauk meistaran\u00e1mi \u00ed efnafr\u00e6\u00f0i 2019 fr\u00e1 Central University of Tamil Nadu \u00e1 Su\u00f0ur-Indlandi og h\u00f3f doktorsn\u00e1m \u00ed efnafr\u00e6\u00f0i hj\u00e1 pr\u00f3fessor Krishna K. Damodaran \u00ed n\u00f3vember sama \u00e1r. Ranns\u00f3knaverkefni hans er \u00e1 svi\u00f0i notkunar \u00e1 gelum me\u00f0 l\u00e1gan sameindamassa til efnam\u00ed\u00f0a \u00e1 fj\u00f6lli\u00f0um sem ra\u00f0a s\u00e9r sj\u00e1lfkrafa upp og geta t.d. mynda\u00f0 snjallefni.<\/p>\n

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