{"id":6408,"date":"2026-10-19T09:48:52","date_gmt":"2026-10-19T09:48:52","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-jon-thorir-oskarsson\/"},"modified":"2026-10-19T09:48:52","modified_gmt":"2026-10-19T09:48:52","slug":"doktorsvorn-i-lif-og-laeknavisindum-jon-thorir-oskarsson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-jon-thorir-oskarsson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf- og l\u00e6knav\u00edsindum J\u00f3n \u00de\u00f3rir \u00d3skarsson"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>F\u00f6studaginn 20. j\u00fan\u00ed 2025 ver J\u00f3n \u00de\u00f3rir \u00d3skarsson doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: Inns\u00fdn \u00ed beinmerginn: Notagildi frumufl\u00e6\u00f0isj\u00e1r vi\u00f0 greiningu \u00e1 g\u00f3\u00f0kynja einstofna m\u00f3tefnah\u00e6kkun. Insights from the bone marrow: Characterization of monoclonal gammopathy of undetermined significance through flow cytometry analysis of plasma cells.\u00a0<\/p>\n<p>Andm\u00e6lendur eru dr. Kwee Yong, pr\u00f3fessor vi\u00f0 Cancer Institute, University College London, og Mona H\u00f8ys\u00e6ter Fenstad, r\u00e1\u00f0gjafi vi\u00f0 St. Olavs-sj\u00fakrah\u00fasi\u00f0 \u00ed \u00der\u00e1ndheimi.\u00a0<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var Sigur\u00f0ur Yngvi Kristinsson, pr\u00f3fessor. Auk hans s\u00e1tu \u00ed doktorsnefnd Alberto Orfao, pr\u00f3fessor, R\u00f3bert P\u00e1lmason, s\u00e9rfr\u00e6\u00f0ingur og\u00a0 Sigr\u00fan \u00deorsteinsd\u00f3ttir, ranns\u00f3knama\u00f0ur.\u00a0<\/p>\n<p>Einar Stef\u00e1n Bj\u00f6rnsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 9.00.\u00a0<\/p>\n<p>\u00c1grip\u00a0<\/p>\n<p>Merg\u00e6xli er illkynja bl\u00f3\u00f0sj\u00fakd\u00f3mur sem einkennist af stj\u00f3rnlausri fj\u00f6lgun og upps\u00f6fnun einstofna plasmafrumna \u00ed beinmerg. \u00deeir sem greinast me\u00f0 merg\u00e6xli hafa \u00e1\u00f0ur veri\u00f0 me\u00f0 forstig \u00feess, g\u00f3\u00f0kynja einstofna m\u00f3tefnah\u00e6kkun (e. monoclonal gammopathy of undetermined significance; MGUS). MGUS er algengt me\u00f0al eldra f\u00f3lks (um 3-5% einstaklinga 50 \u00e1ra og eldri), en a\u00f0eins hluti \u00feeirra \u00fer\u00f3ar me\u00f0 s\u00e9r merg\u00e6xli e\u00f0a skylda sj\u00fakd\u00f3ma \u00e1 l\u00edfslei\u00f0inni. Markmi\u00f0 \u00feessa doktorsverkefnis var a\u00f0 meta kl\u00edn\u00edskt notagildi frumufl\u00e6\u00f0isj\u00e1rranns\u00f3kna \u00e1 plasmafrumum vi\u00f0 greiningu \u00e1 einstaklingum me\u00f0 MGUS. Doktorsritger\u00f0in byggir \u00e1 \u00feremur ranns\u00f3knum \u00fear sem beinmergss\u00fdni fr\u00e1 \u00fe\u00e1tttakendum \u00ed ranns\u00f3kninni Bl\u00f3\u00f0skimun til bjargar, l\u00fd\u00f0grunda\u00f0ri skimunarranns\u00f3kn fyrir MGUS, voru greind me\u00f0 frumufl\u00e6\u00f0isj\u00e1rt\u00e6kni. \u00cd fyrstu ranns\u00f3kninni var \u00fer\u00f3a\u00f0 m\u00f3del til hlutl\u00e6gs mats \u00e1 g\u00e6\u00f0um beinmergss\u00fdna. M\u00f3deli\u00f0 byggir \u00e1 dreifingu frumuh\u00f3pa sem eru sta\u00f0bundnir \u00ed beinmerg og gefa v\u00edsbendingu um umfang bl\u00f3\u00f0mengunar \u00ed beinmergss\u00fdnum. \u00cd annarri ranns\u00f3kninni var greining \u00e1 einstofna plasmafrumum notu\u00f0 til a\u00f0 endurmeta skilgreiningarm\u00f6rk \u00e1 hlutfalli fr\u00edrra l\u00e9ttra ke\u00f0ja \u00ed sermi til greiningar \u00e1 l\u00e9ttke\u00f0ju MGUS. Ni\u00f0urst\u00f6\u00f0urnar benda til \u00feess a\u00f0 n\u00faverandi skilgreiningarm\u00f6rk lei\u00f0i til ofgreiningar \u00e1 l\u00e9ttke\u00f0ju MGUS. \u00cd \u00feri\u00f0ju ranns\u00f3kninni var t\u00ed\u00f0ni og kl\u00edn\u00edsk \u00fe\u00fd\u00f0ing greiningar \u00e1 einstofna plasmafrumum hj\u00e1 einstaklingum me\u00f0 IgA og IgG MGUS metin. Ni\u00f0urst\u00f6\u00f0urnar benda til \u00feess a\u00f0 me\u00f0 frumufl\u00e6\u00f0isj\u00e1rgreiningu s\u00e9 h\u00e6gt a\u00f0 skilgreina undirh\u00f3p MGUS sem er ekki \u00ed aukinni \u00e1h\u00e6ttu \u00e1 a\u00f0 \u00fer\u00f3a me\u00f0 s\u00e9r merg\u00e6xli e\u00f0a skylda sj\u00fakd\u00f3ma. Saman benda ni\u00f0urst\u00f6\u00f0ur doktorsverkefnisins til \u00feess a\u00f0 frumufl\u00e6\u00f0isj\u00e1rranns\u00f3knir geti auki\u00f0 n\u00e1kv\u00e6mni vi\u00f0 greiningu \u00e1 MGUS og stu\u00f0la\u00f0 a\u00f0 b\u00e6ttri \u00e1h\u00e6ttustigun.\u00a0<\/p>\n<p>Abstract\u00a0<\/p>\n<p>Multiple myeloma (MM) is a hematological malignancy characterized by the proliferation and accumulation of malignant plasma cells in the bone marrow (BM). MM is consistently preceded by monoclonal gammopathy of undetermined significance (MGUS), a common, asymptomatic condition affecting 3-5% of individuals aged 50 or older, with a variable risk of progression to MM and related diseases. This PhD thesis evaluates the clinical utility of multiparametric flow cytometry (MFC) in the diagnostic evaluation of MGUS through three studies based on the analysis of BM samples from participants in the Iceland Screens, Treats, or Prevents Multiple Myeloma (iStopMM) population-based screening study. In the first study, a Bone Marrow Quality Index (BMQI) was developed to objectively assess the quality of BM aspirate samples based on the distribution of BM-associated cell populations indicative of hemodilution. The second study refines the serum free light-chain ratio cutoff used for diagnosing light-chain MGUS, demonstrating improved specificity as a surrogate marker of plasma cell clonality. The third study investigated the frequency and clinical significance of clonal plasma cell detection in IgA and IgG MGUS, identifying a subgroup characterized by the absence of clonal plasma cells, transient or stable low-level IgG M-proteins, and no evidence of disease progression. Collectively, these findings highlight the value of MFC-based characterization of MGUS, enhancing diagnostic precision and enabling more accurate risk stratification.\u00a0\u00a0<\/p>\n<p>Um doktorsefni\u00f0\u00a0<\/p>\n<p>J\u00f3n \u00de\u00f3rir \u00d3skarsson er f\u00e6ddur \u00e1ri\u00f0 1990 \u00e1 Akranesi. Hann \u00fatskrifa\u00f0ist af n\u00e1tt\u00farufr\u00e6\u00f0ibraut Fj\u00f6lbrautask\u00f3lans \u00ed Gar\u00f0ab\u00e6 \u00e1ri\u00f0 2010, lauk B.Sc. pr\u00f3fi \u00ed l\u00edffr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2014 og M.Sc. pr\u00f3fi \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 sama h\u00e1sk\u00f3la 2017. S\u00ed\u00f0an hefur J\u00f3n \u00de\u00f3rir starfa\u00f0 vi\u00f0 ranns\u00f3knina Bl\u00f3\u00f0skimun til bjargar, \u00fear sem hann hefur unni\u00f0 a\u00f0 ranns\u00f3knum \u00e1 merg\u00e6xli og forstigum \u00feess. S\u00fa vinna leiddi til \u00feess a\u00f0 hann h\u00f3f doktorsn\u00e1m \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2021. Ranns\u00f3knarverkefni\u00f0 hlaut styrk \u00far V\u00edsindasj\u00f3\u00f0i Krabbameinsf\u00e9lags \u00cdslands. Samhli\u00f0a doktorsn\u00e1mi hefur J\u00f3n \u00de\u00f3rir sinnt b\u00e6\u00f0i kennslu og lei\u00f0beiningu nemenda vi\u00f0 H\u00e1sk\u00f3la \u00cdslands og starfa\u00f0 \u00e1 ranns\u00f3knastofu \u00ed bl\u00f3\u00f0meinafr\u00e6\u00f0i \u00e1 Landsp\u00edtalanum. Foreldrar J\u00f3ns \u00de\u00f3ris eru R\u00f3sa J\u00f3nsd\u00f3ttir og \u00d3skar \u00de\u00f3r\u00f0arson. J\u00f3n \u00de\u00f3rir \u00e1 tvo b\u00f6rn, Kolbein 7 \u00e1ra og Krist\u00ednu 5 \u00e1ra.\u00a0<\/p>\n<\/div><\/div>","protected":false},"featured_media":5771,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2025-06-20T09:00:00+00:00","_phd_date_end":"2025-06-20T12:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Inns\u00fdn \u00ed beinmerginn: Notagildi frumufl\u00e6\u00f0isj\u00e1r vi\u00f0 greiningu \u00e1 g\u00f3\u00f0kynja einstofna m\u00f3tefnah\u00e6kkun. 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