{"id":6371,"date":"2026-10-19T09:48:49","date_gmt":"2026-10-19T09:48:49","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-lara-osk-eggertsdottir-claessen\/"},"modified":"2026-10-19T09:48:49","modified_gmt":"2026-10-19T09:48:49","slug":"doktorsvorn-i-laeknavisindum-lara-osk-eggertsdottir-claessen","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-lara-osk-eggertsdottir-claessen\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – L\u00e1ra \u00d3sk Eggertsd\u00f3ttir Claessen"},"content":{"rendered":"
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Fimmtudaginn 17. okt\u00f3ber 2024 ver L\u00e1ra \u00d3sk Eggertsd\u00f3ttir Claessen doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: Aflei\u00f0ing heilahristings hj\u00e1 \u00ed\u00fer\u00f3ttakonum \u2013 m\u00f6guleg vanstarfsemi \u00ed heiladingli og \u00e1hrif \u00e1 andlega l\u00ed\u00f0an og taugas\u00e1lfr\u00e6\u00f0ilega virkni. Mild traumatic brain injury in female athletes \u2013 possible pituitary dysfunction and effect on psychological and neuropsychological function. <\/strong><\/p>\n

Andm\u00e6lendur eru dr. Ulla Feldt-Rasmussen, pr\u00f3fessor emeritus vi\u00f0 Rigshospitalet \u00ed Kaupmannah\u00f6fn, og dr. Per Dahlqvist, d\u00f3sent vi\u00f0 Ume\u00e5 Universitet \u00ed Sv\u00ed\u00fej\u00f3\u00f0.<\/p>\n

Umsj\u00f3narkennari var Ragnar Gr\u00edmur Bjarnason, pr\u00f3fessor vi\u00f0 L\u00e6knadeild, og lei\u00f0beinandi var Helga \u00c1g\u00fasta Sigurj\u00f3nsd\u00f3ttir, kl\u00edn\u00edskur pr\u00f3fessor. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd Hafr\u00fan Kristj\u00e1nsd\u00f3ttir pr\u00f3fessor, Mar\u00eda Krist\u00edn J\u00f3nsd\u00f3ttir pr\u00f3fessor, og Sigr\u00fan Helga Lund pr\u00f3fessor.<\/p>\n

\u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 9.00.<\/p>\n

\u00c1grip <\/strong><\/p>\n

Heilahristingur getur leitt til vanstarfsemi \u00ed heiladingli (VH) og \u00fear me\u00f0 truflun \u00e1 framlei\u00f0slu heiladingulshorm\u00f3na. \u00c1\u00e6tla\u00f0 algengi VH eftir heilahristing er 13\u201348%. Einkenni VH l\u00edkjast einkennum heilahristings en eru me\u00f0h\u00f6ndlanleg og endurspegla \u00fev\u00ed m\u00f6gulega me\u00f0h\u00f6ndlanlega ors\u00f6k fyrir heilahristingseinkennum. Flestar ranns\u00f3knir var\u00f0andi VH eftir heilahristing hafa veri\u00f0 ger\u00f0ar \u00e1 k\u00f6rlum og \u00ed\u00fer\u00f3ttakonur veri\u00f0 mun minna rannsaka\u00f0ar \u00fer\u00e1tt fyrir a\u00f0 n\u00fdgengi heilahristings s\u00e9 h\u00e6rra hj\u00e1 konum og bataferli\u00f0 s\u00e9 lengra. Markmi\u00f0 \u00feessa doktorsverkefnis var me\u00f0al annars a\u00f0 meta algengi VH eftir heilahristing hj\u00e1 \u00ed\u00fer\u00f3ttakonum, a\u00f0 bera kennsl \u00e1 \u00fe\u00e6r \u00ed\u00fer\u00f3ttakonur sem \u00feurfa frekari uppvinnslu vegna gruns um VH eftir heilahristing og a\u00f0 finna m\u00f6gulega forsp\u00e1r\u00fe\u00e6tti fyrir VH eftir heilahristing, \u00fear me\u00f0 tali\u00f0 taugas\u00e1lfr\u00e6\u00f0ilega og s\u00e1lfr\u00e6\u00f0ilega forsp\u00e1r\u00fe\u00e6tti. Markmi\u00f0 verkefnisins var einnig a\u00f0 bera saman taugas\u00e1lfr\u00e6\u00f0ilega frammist\u00f6\u00f0u, andlega l\u00ed\u00f0an og l\u00edfsg\u00e6\u00f0i hj\u00e1 \u00ed\u00fer\u00f3ttakonum me\u00f0 VH eftir heilahristing og \u00ed\u00fer\u00f3ttakonum me\u00f0 e\u00f0lilega starfsemi \u00ed heiladingli eftir heilahristing. Samkv\u00e6mt okkar bestu vitund er ranns\u00f3knin s\u00fa fyrsta sem fjallar um algengi VH eftir heilahristing, taugas\u00e1lfr\u00e6\u00f0ilega frammist\u00f6\u00f0u, andlega l\u00ed\u00f0an og l\u00edfsg\u00e6\u00f0i \u00ed \u00fe\u00fd\u00f0i \u00ed\u00fer\u00f3ttakvenna.<\/p>\n

\u00de\u00fd\u00f0i ranns\u00f3knarinnar var st\u00f3rt \u00fear sem ranns\u00f3knarh\u00f3purinn samanst\u00f3\u00f0 upprunalega af 508 konum sem t\u00f3ku \u00fe\u00e1tt me\u00f0 \u00fev\u00ed a\u00f0 svara rafr\u00e6num spurningalista um heilahristingss\u00f6gu og andlega l\u00ed\u00f0an. Af \u00feessum konum h\u00f6f\u00f0u 308 konur fengi\u00f0 heilahristing og af \u00feeim t\u00f3ku 133 konur \u00fe\u00e1tt \u00ed \u00edtarlegri horm\u00f3nauppvinnslu. Sext\u00e1n konur (12,2%) greindust me\u00f0 VH eftir heilahristing. Ranns\u00f3knin undirstrikar mikilv\u00e6gi \u00feess a\u00f0 meta starfsemi heiladinguls eftir heilahristing \u00fear sem umtalsver\u00f0ur fj\u00f6ldi \u00ed\u00fer\u00f3ttakvenna var greindur me\u00f0 VH eftir heilahristing.<\/p>\n

Abstract <\/strong><\/p>\n

Hypopituitarism (HP) can occur following mild traumatic brain injury (mTBI) with an estimated a prevalence of 13 \u2013 48%. As symptoms of HP may overlap with symptoms of mTBI and HP can be treated with hormonal replacement therapy, HP represents a potentially treatable cause of mTBI symptoms. Female athletes remain an understudied population as studies on HP following mTBI have predominantly included male populations even though the incidence of mTBI appears to be greater and recovery time is longer in women compared to men. The aims of this thesis included finding the prevalence of PD following mTBI in female athletes, identifying female athletes needing further evaluation for possible pituitary dysfunction (PD) following mTBI, and identifying possible predictive factors for PD after mTBI, including psychological and neuropsychological predictive factors. We also aimed to compare neuropsychological and psychological symptoms as well as quality of life (QOL) between women with PD following mTBI and women with normal pituitary function (nPF). To the best of our knowledge, this study is the first to report the prevalence of PD after mTBI and the effect of PD on neuropsychological and psychological outcome and QOL in an all-female population.<\/p>\n

The study population was large as 508 female athletes participated in the study by answering an online questionnaire regarding mTBI history and mental health. One or more mTBI was reported by 308 women and a detailed endocrinological evaluation was performed for 133 women of them. Sixteen women (12.2%) were diagnosed with PD following mTBI. The study emphasizes the importance of evaluating pituitary function following mTBI as a substantial number of female athletes were diagnosed with PD after mTBI.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

L\u00e1ra \u00d3sk Eggertsd\u00f3ttir Claessen er f\u00e6dd \u00e1ri\u00f0 1990 \u00ed Reykjav\u00edk. H\u00fan \u00fatskrifa\u00f0ist af n\u00e1tt\u00farufr\u00e6\u00f0ibraut Menntask\u00f3lans \u00ed Reykjav\u00edk \u00e1ri\u00f0 2010 og lauk emb\u00e6ttispr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2016. Eftir kand\u00eddats\u00e1r starfa\u00f0i L\u00e1ra \u00d3sk \u00e1 Grens\u00e1sdeild Landsp\u00edtalans, sem kveikti \u00e1huga hennar \u00e1 me\u00f0fer\u00f0 sj\u00faklinga eftir heila\u00e1verka. H\u00fan h\u00f3f doktorsn\u00e1m \u00e1ri\u00f0 2018 \u00fear sem h\u00fan hefur rannsaka\u00f0 \u00e1hrif heilahristings \u00e1 starfsemi heiladinguls hj\u00e1 \u00ed\u00fer\u00f3ttakonum. Samhli\u00f0a doktorsn\u00e1mi hefur h\u00fan stunda\u00f0 s\u00e9rn\u00e1m \u00ed br\u00e1\u00f0al\u00e6kningum \u00e1 Landsp\u00edtalanum. Foreldrar L\u00e1ru eru Gr\u00edma Huld Bl\u00e6ngsd\u00f3ttir og Jean Eggert Hjartarson Claessen. Samb\u00fdlisma\u00f0ur L\u00e1ru \u00d3skar er Magn\u00fas Ingvi Magn\u00fasson og eiga \u00feau saman tv\u00e6r d\u00e6tur, Au\u00f0i Huld Magn\u00fasd\u00f3ttur og Heklu Magn\u00fasd\u00f3ttur.<\/p>\n

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