{"id":6323,"date":"2026-10-19T09:48:46","date_gmt":"2026-10-19T09:48:46","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-elisabet-alexandra-frick\/"},"modified":"2026-10-19T09:48:46","modified_gmt":"2026-10-19T09:48:46","slug":"doktorsvorn-i-lif-og-laeknavisindum-elisabet-alexandra-frick","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-elisabet-alexandra-frick\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf- og l\u00e6knav\u00edsindum &#8211; El\u00edsabet Alexandra Frick"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Fimmtudaginn 30. mars 2023 ver El\u00edsabet Alexandra Frick doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: MicroRNA-190b \u00ed brj\u00f3sta- og eggjastokkakrabbameini. MicroRNA-190b in breast and ovarian cancer.<\/p>\n<p>Andm\u00e6lendur eru dr. Carolyn M. Klinge, pr\u00f3fessor vi\u00f0 University of Louisville School of Medicine, og dr. Bylgja Hilmarsd\u00f3ttir, ranns\u00f3knars\u00e9rfr\u00e6\u00f0ingur \u00e1 Landsp\u00edtalanum.<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var Stef\u00e1n \u00de. Sigur\u00f0sson, pr\u00f3fessor, og me\u00f0lei\u00f0beinandi var \u00deorkell Gu\u00f0j\u00f3nsson. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd J\u00f3runn Erla Eyfj\u00f6r\u00f0, pr\u00f3fessor emeritus, Arnar P\u00e1lsson, pr\u00f3fessor og \u00c1sger\u00f0ur Sverrisd\u00f3ttir, s\u00e9rfr\u00e6\u00f0ingur.<\/p>\n<p>Dr. \u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 13.00.<\/p>\n<p><strong>\u00c1grip<\/strong><\/p>\n<p>Brj\u00f3stakrabbamein er algengasta ger\u00f0 krabbameins sem greinist \u00ed dag og eru algengustu undirger\u00f0ir \u00feess Luminal A og Luminal B. \u00deessar undirger\u00f0ir yfirtj\u00e1 estr\u00f3genvi\u00f0takann (ER+) sem er lykil\u00fe\u00e1ttur \u00ed myndun \u00feeirra og tekur me\u00f0fer\u00f0 mi\u00f0 af \u00fev\u00ed. MicroRNA (MiRNA) eru RNA-sameindir sem tj\u00e1 ekki fyrir pr\u00f3teini en gegna hlutverki \u00ed gena\u00fe\u00f6ggun eftir DNA umritun. S\u00fdnt haf\u00f0i veri\u00f0 fram \u00e1 a\u00f0 microRNA-190b er yfirtj\u00e1\u00f0 \u00ed ER+ brj\u00f3stakrabbameinum en \u00f6rf\u00e1 markgen hafa veri\u00f0 bendlu\u00f0 vi\u00f0 sameindina. \u00cd \u00feessu verkefni var sta\u00f0fest a\u00f0 miR-190b er yfirtj\u00e1\u00f0 \u00ed ER+ brj\u00f3stakrabbameinum og a\u00f0 tap \u00e1 DNA met\u00fdlun \u00e1 st\u00fdrilsv\u00e6\u00f0i tengist yfirtj\u00e1ningu \u00feess \u00ed meinunum. Einnig var s\u00fdnt a\u00f0 munur v\u00e6ri \u00e1 brj\u00f3stakrabbameinsh\u00e1\u00f0ri lifun sj\u00faklinga eftir \u00fev\u00ed hvort tap haf\u00f0i veri\u00f0 \u00e1 DNA-met\u00fdlun \u00e1 st\u00fdrisv\u00e6\u00f0i miR-190b \u00ed krabbameinunum e\u00f0a ekki. Markgen miR-190b \u00ed brj\u00f3stakrabbameini voru ranns\u00f6ku\u00f0 og sko\u00f0a\u00f0 hvort st\u00fdring \u00e1 \u00feeim hef\u00f0i svipa\u00f0 forsp\u00e1gildi \u00e1 horfur sj\u00faklinga. \u00dea\u00f0 fannst og sta\u00f0festist a\u00f0 RFWD3 er markgen miR-190b og a\u00f0 horfur sj\u00faklinga eru verri \u00feegar \u00fea\u00f0 er yfirtj\u00e1\u00f0 \u00ed meinunum. Loks var rannsaka\u00f0 miR190b \u00ed eggjastokkakrabbameini og s\u00e1st a\u00f0 hvorki eru tengsl milli miR-190b tj\u00e1ningar og ER n\u00e9 RFWD3 tj\u00e1ningar \u00ed \u00feessari ger\u00f0 krabbameins. Samt sem \u00e1\u00f0ur eru horfur eggjastokkakrabbameinssj\u00faklinga verri hj\u00e1 \u00feeim sem hafa h\u00e1a tj\u00e1ningu miR-190b \u00ed meinunum sem bendir til \u00feess a\u00f0 \u00fea\u00f0 s\u00e9 mikilv\u00e6gt \u00ed kl\u00edn\u00edsku samhengi og \u00fearfnast frekari ranns\u00f3knar.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Breast cancer is the most frequently diagnosed cancer today with Luminal A and Luminal B being the most common subtypes. These subtypes overexpress the estrogen receptor (ER+) which is a key factor in their development and treatment. MicroRNAs (MiRNAs) are RNA molecules which do not code for protein but have a role in gene silencing post DNA transcription. A previous study had shown that microRNA-190b (miR-190b) was upregulated in ER+ breast cancer but few target genes had been associated with the molecule. In this project we confirmed that miR-190b is overexpressed in ER+ breast cancers which is associated with loss of DNA methylation in its promoter region. We also showed that that there was a difference in breast cancer specific patient survival depending on miR-190b hyper- or hypo-methylation in the tumors. MiR-190b\u2019s target transcripts were taken into consideration and we studied whether their expression regulation had a similar influence on patient prognosis. We found and confirmed that RFWD3 is a miR-190b target, and that patient prognosis is worse when it is overexpressed in breast cancer. Finally, we studied miR-190b in ovarian cancer and saw that there was neither a connection between miR-190b expression and ER nor RFWD3 expression in this cancer type. However, we saw that patient prognosis was worse in ovarian cancer patients with high levels of miR-190b in their tumors indicating that it is clinically relevant in this cancer type and needs to be studied further.<\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>El\u00edsabet Alexandra Frick er f\u00e6dd \u00e1ri\u00f0 1990 \u00ed Keflav\u00edk. H\u00fan lauk st\u00fadentspr\u00f3fi \u00e1ri\u00f0 2012 og B.Sc-gr\u00e1\u00f0u \u00ed l\u00edffr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2015. El\u00edsabet h\u00f3f doktorsn\u00e1m \u00e1ri\u00f0 2016 og hefur s\u00ed\u00f0an starfa\u00f0 a\u00f0 doktorsverkefni s\u00ednu. Samhli\u00f0a n\u00e1minu hefur h\u00fan veri\u00f0 a\u00f0sto\u00f0arkennari vi\u00f0 H\u00e1sk\u00f3la \u00cdslands, skipuleggjandi fyrirlestrara\u00f0ar l\u00edfv\u00edsindaseturs (BMC), seti\u00f0 \u00ed stj\u00f3rn Samtaka krabbameinsranns\u00f3kna \u00e1 \u00cdslandi og \u00ed stj\u00f3rn Doktorsnemar\u00e1\u00f0s Heilbrig\u00f0isv\u00edsindasvi\u00f0s. El\u00edsabet starfar n\u00fa sem n\u00fddoktor hj\u00e1 Hjartavernd og stundar ranns\u00f3knir \u00e1 svi\u00f0um faralds- og erf\u00f0afr\u00e6\u00f0i. Foreldrar hennar eru Hans\u00edna Sj\u00f6fn Steingr\u00edmsd\u00f3ttir og Terry Frick. Samb\u00fdlisma\u00f0ur El\u00edsabetar er Francesco Barbaccia og eiga \u00feau soninn Anton S. Sjafnar Barbaccia.<\/p>\n<\/div><\/div>","protected":false},"featured_media":5607,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2023-03-30T13:00:00+00:00","_phd_date_end":"2023-03-30T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0aalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"MicroRNA-190b \u00ed brj\u00f3sta- og eggjastokkakrabbameini. 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