{"id":6301,"date":"2026-10-19T09:48:44","date_gmt":"2026-10-19T09:48:44","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-gisli-thor-axelsson\/"},"modified":"2026-10-19T09:48:44","modified_gmt":"2026-10-19T09:48:44","slug":"doktorsvorn-i-laeknavisindum-gisli-thor-axelsson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-gisli-thor-axelsson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – G\u00edsli \u00de\u00f3r Axelsson"},"content":{"rendered":"
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F\u00f6studaginn 30. september ver G\u00edsli \u00de\u00f3r Axelsson doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: Millivefslungnabreytingar og \u00f6ldrunartengdir \u00fe\u00e6ttir. Interstitial lung abnormalities and aging-related factors.<\/p>\n

Andm\u00e6lendur eru dr. Gisli Jenkins, ranns\u00f3knapr\u00f3fessor vi\u00f0 National Heart and Lung Institute, Imperial College London, og dr. Timothy Blackwell, pr\u00f3fessor vi\u00f0 Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University \u00ed Nashville, Tennessee.<\/p>\n

Umsj\u00f3narkennari og lei\u00f0beinandi var Gunnar Gu\u00f0mundsson pr\u00f3fessor og me\u00f0lei\u00f0beinandi var Thor Aspelund pr\u00f3fessor, b\u00e1\u00f0ir vi\u00f0 L\u00e6knadeild. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd dr. Gary Matthew Hunninghake, d\u00f3sent vi\u00f0 Harvard Medical School, og Vilmundur Gu\u00f0nason, pr\u00f3fessor.<\/p>\n

\u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 13.00.<\/p>\n

V\u00f6rninni ver\u00f0ustreymt:\u00a0<\/p>\n

https:\/\/livestream.com\/hi\/doktorsvorngislithoraxelsson<\/a><\/p>\n

\u00c1grip<\/strong><\/p>\n

Millivefslungnasj\u00fakd\u00f3mar eru sj\u00fakd\u00f3mar sem leggjast helst \u00e1 eldra f\u00f3lk, einkennast af \u00f6rvefsmyndun \u00ed lungum og hafa oft sl\u00e6mar horfur. Millivefslungnabreytingar (MLB) eru breytingar \u00e1 myndgreiningu af lungum sem l\u00edkjast millivefslungnasj\u00fakd\u00f3mum en eru skilgreindar \u00ed \u00fe\u00e1tttakendum ferilranns\u00f3kna \u00e1n \u00feekkts millivefslungnasj\u00fakd\u00f3ms. Vegna sterkra tengsla MLB og millivefslungnasj\u00fakd\u00f3ma vi\u00f0 h\u00e1an aldur var markmi\u00f0 ritger\u00f0arinnar a\u00f0 kanna tengsl MLB vi\u00f0 \u00f6ldrunartengda l\u00edfv\u00edsa og sj\u00fakd\u00f3ma sem tengjast aldri og \u00f6ldrun.<\/p>\n

G\u00f6gn \u00far \u00feremur ferilranns\u00f3knum, \u00d6ldrunarranns\u00f3kn Hjartaverndar, Genetic epidemiology of COPD (COPDGene) ranns\u00f3kninni og Framingham hjartaranns\u00f3kninni voru notu\u00f0 til a\u00f0 kanna tengsl hugl\u00e6gra m\u00e6likvar\u00f0a heilsu og virkni, greininga og d\u00e1nart\u00ed\u00f0ni vegna lungnakrabbameina og annarra krabbameina, sermisstyrk pr\u00f3teina og lengd litningaenda \u00ed hv\u00edtkornum vi\u00f0 MLB.<\/p>\n

Helstu ni\u00f0urst\u00f6\u00f0urnar voru a\u00f0 MLB tengdust minni l\u00edkum \u00e1 sj\u00e1lfst\u00e6\u00f0i vi\u00f0 athafnir daglegs l\u00edfs, minni l\u00edkum \u00e1 a\u00f0 \u00fe\u00e1tttakendum fyndust \u00feeir vera vi\u00f0 g\u00f3\u00f0a heilsu og minni l\u00edkum \u00e1 reglulegri hreyfingu. Einnig tengdust MLB greiningum lungnakrabbameina og d\u00e1nart\u00ed\u00f0ni vegna lungnakrabbameina en ekki greiningum annarra krabbameina e\u00f0a d\u00e1nart\u00ed\u00f0ni vegna \u00feeirra. Sermisstyrkur 287 pr\u00f3teina tengdist tilvist MLB \u00ed lei\u00f0r\u00e9ttum a\u00f0hvarfsgreiningum. Markt\u00e6kust tengsl fundust fyrir Surfactant protein B (SFTPB), Secretoglobin family 3A member 1 (SCGB3A1) og WAP four-disulfide core domain protein 2 (WFDC2). Hva\u00f0 var\u00f0ar MLB og lengd litningaenda, reyndist styttri litningaendalengd tengjast MLB en ekki var s\u00fdnt fram \u00e1 tengsl litningaendalengdar vi\u00f0 lifun me\u00f0al \u00fe\u00e1tttakenda me\u00f0 MLB.<\/p>\n

\u00deessar ni\u00f0urst\u00f6\u00f0ur s\u00fdna fram \u00e1 tengsl MLB vi\u00f0 \u00fdmsa \u00f6ldrunartengda \u00fe\u00e6tti og kl\u00edn\u00edskar \u00fatkomur. Til vi\u00f0b\u00f3tar benda ni\u00f0urst\u00f6\u00f0ur til margra pr\u00f3teina sem n\u00fdrra l\u00edfv\u00edsa MLB \u00ed bl\u00f3\u00f0i, en sum \u00feeirra hafa \u00feekkt tengsl vi\u00f0 \u00f6ldrun. \u00cd heild auka ni\u00f0urst\u00f6\u00f0urnar \u00feekkingu \u00e1 l\u00edffr\u00e6\u00f0ilegum eiginleikum og faraldsfr\u00e6\u00f0ilegri \u00e1h\u00e6ttu f\u00f3lks me\u00f0 myndgreiningarbreytingar sem bent g\u00e6tu til snemmb\u00fainnar lungnatrefjunar.<\/p>\n

Abstract<\/strong><\/p>\n

Interstitial lung diseases (ILD), such as idiopathic pulmonary fibrosis (IPF), are diseases of elderly people that are characterised by pulmonary deposition of fibrous tissue and often have a poor prognosis. Interstitial lung abnormalities (ILA) are radiologic changes that are similar in appearance to ILD but are characterised in cohort study participants without known ILD. Due to the strong links that ILA and ILD share with advanced aging, the aims of the thesis were to assess the relationship of ILA with aging-related biological markers and outcomes.<\/p>\n

Data from three cohort studies, the Age\/Gene-Environment Susceptibility-Reykjavik (AGES-Reykjavik) study, the Genetic epidemiology of COPD (COPDGene) study and the Framingham Heart study were used to assess the associations of ILA with functional status, pulmonary and extra-pulmonary malignancies, a variety of blood proteins and leukocyte telomere length.<\/p>\n

The main findings were that participants with ILA were less likely to be independent in activities of daily living, to perceive their health as good or better and to be regularly physically active. ILA were also associated with diagnoses of lung cancer and mortality from lung cancer but not with diagnoses of, or mortality from, cancers excluding lung cancer. Among serum proteins measured, 287 proteins were significantly associated with ILA. The most significant associations were for Surfactant protein B (SFTPB), Secretoglobin family 3A member 1 (SCGB3A1) and WAP four-disulfide core domain protein 2 (WFDC2). As for analyses of ILA and leukocyte telomere length, shorter telomere length was associated with increased odds of ILA but a significant association of telomere length with mortality among those with ILA was not demonstrated.<\/p>\n

These cohort study-based data demonstrate the associations of ILA with several aging-related markers and outcomes. Additionally, many novel protein biomarkers of ILA are proposed, some of them previously related to aging. These findings improve knowledge of biological markers and epidemiological outcomes associated with ILA as a possible marker of early pulmonary fibrosis.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

G\u00edsli \u00de\u00f3r Axelsson er f\u00e6ddur \u00e1ri\u00f0 1995 \u00e1 Selfossi. Hann lauk st\u00fadentspr\u00f3fi af n\u00e1tt\u00farufr\u00e6\u00f0ibraut Fj\u00f6lbrautask\u00f3la Su\u00f0urlands \u00e1ri\u00f0 2013. Hann lauk bakkal\u00e1rgr\u00e1\u00f0u \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands 2017 og emb\u00e6ttispr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 sama sk\u00f3la 2020. Samhli\u00f0a doktorsn\u00e1minu lauk G\u00edsli kand\u00eddats\u00e1ri og h\u00f3f s\u00e9rn\u00e1m \u00ed almennum lyfl\u00e6kningum vi\u00f0 Landsp\u00edtalann. Foreldrar G\u00edsla eru Axel \u00de\u00f3r Gissurarson og \u00c1sd\u00eds Bj\u00f6rg Ingvarsd\u00f3ttir. Eiginkona G\u00edsla er Au\u00f0ur Gunnarsd\u00f3ttir l\u00e6knir.<\/p>\n<\/div><\/div>","protected":false},"featured_media":5258,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2022-09-30T13:00:00+00:00","_phd_date_end":"2022-09-30T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Millivefslungnabreytingar og \u00f6ldrunartengdir \u00fe\u00e6ttir. 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