{"id":6286,"date":"2026-10-19T09:48:43","date_gmt":"2026-10-19T09:48:43","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-kristin-leifsdottir\/"},"modified":"2026-10-19T09:48:43","modified_gmt":"2026-10-19T09:48:43","slug":"doktorsvorn-i-laeknavisindum-kristin-leifsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-kristin-leifsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – Krist\u00edn Leifsd\u00f3ttir"},"content":{"rendered":"
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F\u00f6studaginn 3. j\u00fan\u00ed ver Krist\u00edn Leifsd\u00f3ttir doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: L\u00edfefni \u00ed m\u00e6nuv\u00f6kva n\u00fdbura; forsp\u00e1rgildi fyrir heilaska\u00f0a: Tengsl vi\u00f0 lifun og r\u00f6skun \u00e1 tauga\u00feroska. Biomarkers in cerebrospinal fluid of neonates at risk of brain injury: Association with death and disability.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. Deirdre Murray, pr\u00f3fessor vi\u00f0 University College \u00ed Cork, \u00cdrlandi og dr. Frances Cowan, gestapr\u00f3fessor\/kl\u00edn\u00edskur d\u00f3sent vi\u00f0 Imperial College \u00ed London.<\/p>\n

Umsj\u00f3narkennari var \u00c1sgeir Haraldsson, pr\u00f3fessor og lei\u00f0beinandi var Eric Herlenius, pr\u00f3fessor. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd \u00de\u00f3r\u00f0ur \u00de\u00f3rkelsson, s\u00e9rfr\u00e6\u00f0ingur, Ingileif J\u00f3nsd\u00f3ttir, pr\u00f3fessor og Staffan Eksborg, pr\u00f3fessor emeritus.<\/p>\n

\u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 13.00.<\/p>\n

V\u00f6rninni ver\u00f0ur streymt:<\/p>\n

https:\/\/livestream.com\/hi\/doktorsvornkristinleifsdottir<\/a><\/p>\n

\u00c1grip<\/strong><\/p>\n

B\u00f6rn sem ver\u00f0a fyrir s\u00farefnisskorti \u00ed f\u00e6\u00f0ingu og b\u00f6rn sem f\u00e6\u00f0ast fyrir fulla me\u00f0g\u00f6ngu eiga \u00e1 h\u00e6ttu a\u00f0 lifa ekki af e\u00f0a hlj\u00f3ta varanlega heilaska\u00f0a. H\u00e6ttan \u00e1 \u00feessum fylgikvillum hefur ekki minnka\u00f0 \u00e1 s\u00ed\u00f0ustu \u00e1ratugum \u00fer\u00e1tt fyrir miklar l\u00e6knisfr\u00e6\u00f0ilegar framfarir. S\u00fdkingar eru algengur fylgikvilli fyrirburaskapar og geta haft \u00e1hrif \u00e1 tauga\u00feroska. Markmi\u00f0 \u00feessa verkefnis var a\u00f0 finna l\u00edfefni \u00ed m\u00e6nuv\u00f6kva til a\u00f0 greina heilaska\u00f0a og meta \u00e1h\u00e6ttu \u00e1 tauga\u00feroskar\u00f6skun hj\u00e1 n\u00fdburum. L\u00edfefni voru m\u00e6ld \u00ed m\u00e6nuv\u00f6kva hj\u00e1 fullbur\u00f0a b\u00f6rnum sem uppfylltu skilyr\u00f0i fyrir heilakvilla af v\u00f6ldum s\u00farefnisskorts \u00ed f\u00e6\u00f0ingu og hj\u00e1 fyrirburum og fullbur\u00f0a b\u00f6rnum sem h\u00f6f\u00f0u einkenni um bl\u00f3\u00f0s\u00fdkingu. Ranns\u00f3knarh\u00f3purinn voru b\u00f6rn som voru innl\u00f6g\u00f0 \u00e1 n\u00fdburagj\u00f6rg\u00e6sludeild Karolinska sj\u00fakrah\u00fassins \u00e1 t\u00edmabilinu 2000 til 2004.<\/p>\n

Ni\u00f0urst\u00f6\u00f0ur ranns\u00f3knanna benda \u00ed fyrsta lagi til a\u00f0 magn b\u00f3lguefna aukist \u00ed m\u00e6nuv\u00f6kva, b\u00e6\u00f0i vi\u00f0 bl\u00f3\u00f0s\u00fdkingar og f\u00f3sturk\u00f6fnun, og hafi notagildi vi\u00f0 greiningu \u00e1 sj\u00fakd\u00f3ms\u00e1standi og forsp\u00e1rgildi um horfur sj\u00faklinga. \u00cd \u00f6\u00f0ru lagi a\u00f0 \u00fdmis pr\u00f3tein sem tengjast efnaferlum \u00ed meinger\u00f0 heilaska\u00f0a af v\u00f6ldum s\u00farefnisskorts safnist upp \u00ed m\u00e6nuv\u00f6kva eftir f\u00f3sturk\u00f6fnun. A\u00f0 auki\u00f0 magn \u00feessara pr\u00f3teina tengist verri heilaska\u00f0a og magn \u00feeirra \u00ed m\u00e6nuv\u00f6kva hafi tengsl vi\u00f0 framt\u00ed\u00f0arhorfur barnanna. \u00cd \u00feri\u00f0ja lagi var s\u00fdnt a\u00f0 pr\u00f3tein-svipger\u00f0 \u00ed m\u00e6nuv\u00f6kva er ekki eins hj\u00e1 fyrirburum og hj\u00e1 fullbur\u00f0a b\u00f6rnum. Einnig s\u00e1st a\u00f0 hj\u00e1 fyrirburum sem greindust me\u00f0 tauga\u00feroskaraskanir fyrir tveggja \u00e1ra aldur var skortur \u00e1 \u00fdmsum pr\u00f3teinum sem taka \u00fe\u00e1tt \u00ed \u00feroska heilans.<\/p>\n

\u00dat fr\u00e1 \u00feessum ni\u00f0urst\u00f6\u00f0um var \u00e1lykta\u00f0 a\u00f0 \u00fdmis b\u00f3lguefni og \u00f6nnur l\u00edfefni \u00ed m\u00e6nuv\u00f6kva sem tengjast heilanum geti veri\u00f0 gagnleg vi\u00f0 mat \u00e1 \u00e1standi og horfum n\u00fdbura sem eru \u00ed h\u00e6ttu \u00e1 heilaska\u00f0a og tauga\u00feroskar\u00f6skun.<\/p>\n

English abstract<\/strong><\/p>\n

Prematurity with its complications, including infections, and hypoxic-ischemic encephalopathy (HIE) following birth asphyxia in full-term infants are the most important contributors to a high incidence of early neonatal mortality and lifelong neurodevelopmental disabilities originating in the neonatal period. Devastating long-term outcomes have not decreased markedly within the last decades despite extensive medical advances. The focus of this thesis was to discover biomarkers in cerebrospinal fluid (CSF) that would diagnose perinatal brain injury and identify infants at risk of adverse neurodevelopmental outcomes.<\/p>\n

We analyzed CSF from term infants who fulfilled the criteria of perinatal asphyxia and preterm and term infants with suspected infection. The infants were cared for at the neonatal intensive care unit at the Karolinska Hospital in Stockholm between 2000 and 2004. Our main findings were, firstly, that inflammatory biomarkers were increased in CSF in response to both asphyxia and sepsis and that they had diagnostic and prognostic values. Secondly, unique brain-specific proteins were increased in CSF of asphyxiated infants and correlated with the extent of brain injury and clinical outcome. Thirdly, decreased levels of neurodevelopmentally related proteins correlated with unfavorable neurodevelopmental outcomes of preterm infants.<\/p>\n

From these results, it may be concluded that several inflammatory- as well as structural and functional brain-specific biomarkers could serve as diagnostic tools in infants at risk of brain injury.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Krist\u00edn Leifsd\u00f3ttir er f\u00e6dd \u00e1ri\u00f0 1966 \u00ed Reykjav\u00edk. H\u00fan lauk st\u00fadentspr\u00f3fi af e\u00f0lisfr\u00e6\u00f0ibraut fr\u00e1 Menntask\u00f3lanum vi\u00f0 Sund \u00e1ri\u00f0 1986 og \u00fatskrifa\u00f0ist \u00far l\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 1994. H\u00fan lauk framhaldsn\u00e1mi \u00ed barnal\u00e6knisfr\u00e6\u00f0i og n\u00fdbural\u00e6kningum fr\u00e1 Karolinska Institutet \u00ed Stokkh\u00f3lmi \u00e1ri\u00f0 2004 \u00fear sem h\u00fan vann einnig hluta af doktorsverkefninu. Krist\u00edn hefur starfa\u00f0 sem s\u00e9rfr\u00e6\u00f0ingur \u00e1 V\u00f6kudeild Barnasp\u00edtala Hringsins fr\u00e1 \u00e1rinu 2005. H\u00fan hefur einnig veri\u00f0 stundakennari vi\u00f0 l\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands og kennt um heilaska\u00f0a n\u00fdbura. Fr\u00e1 2012 hefur h\u00fan teki\u00f0 \u00fe\u00e1tt \u00ed \u00feverfaglegri teymisvinnu um eftirlit me\u00f0 fyrirburum \u00e1 \u00cdslandi. Krist\u00edn \u00e1 tvo drengi, Kristj\u00e1n J\u00fal\u00edan sem nemur h\u00fakrunarfr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands og J\u00f3hann Hauk sem er \u00ed Verzl\u00f3. Foreldrar hennar eru Reg\u00edna Vigg\u00f3sd\u00f3ttir leiksk\u00f3lakennari og Leifur Teitsson p\u00edpulagningameistari, en hann l\u00e9st \u00e1ri\u00f0 2014.<\/p>\n<\/div><\/div>","protected":false},"featured_media":5145,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2022-06-03T13:00:00+00:00","_phd_date_end":"2022-06-03T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"L\u00edfefni \u00ed m\u00e6nuv\u00f6kva n\u00fdbura; forsp\u00e1rgildi fyrir heilaska\u00f0a: Tengsl vi\u00f0 lifun og r\u00f6skun \u00e1 tauga\u00feroska. 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