{"id":6220,"date":"2026-10-19T09:48:38","date_gmt":"2026-10-19T09:48:38","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-efnafraedi-lindsey-jean-monger\/"},"modified":"2026-10-19T09:48:38","modified_gmt":"2026-10-19T09:48:38","slug":"doktorsvorn-i-efnafraedi-lindsey-jean-monger","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-efnafraedi-lindsey-jean-monger\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed efnafr\u00e6\u00f0i – Lindsey Jean Monger"},"content":{"rendered":"
\n
\n

V\u00f6rninni ver\u00f0ur streymt<\/a><\/p>\n

Doktorsefni:<\/strong>\u00a0Lindsey Jean Monger<\/p>\n

Heiti ritger\u00f0ar:<\/strong> Efnasm\u00ed\u00f0ar sm\u00e1pept\u00ed\u00f0a, Pd(II) og Ni(II) komplexar og hagn\u00fdting \u00feeirra vi\u00f0 virkjun l\u00edtilla sameinda (Synthesis of Tripeptides, Pd(II) and Ni(II) Complexes and their Potential Use in Activation of Small Molecules)<\/p>\n

Andm\u00e6lendur:
<\/strong>Dr. Marc Devocelle, pr\u00f3fessor vi\u00f0 Royal College of Surgeons, Dublin, \u00cdrlandi
Dr. Elzbieta Gumienna-Kontecka, pr\u00f3fessor vi\u00f0 University of Wroclaw, P\u00f3llandi<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. Sigr\u00ed\u00f0ur G. Suman, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Einnig \u00ed doktorsnefnd:<\/strong>
Dr. Krishna K. Damodaran, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands
Dr. Stef\u00e1n J\u00f3nsson, teymisstj\u00f3ri hj\u00e1 Alvotech<\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Einar \u00d6rn Sveinbj\u00f6rnsson, pr\u00f3fessor og deildarforseti Raunv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands<\/p>\n

\u00c1grip<\/strong><\/p>\n

Notkun verndarh\u00f3pa \u00e1 virka h\u00f3pa am\u00edn\u00f3s\u00fdra \u00ed litlum pept\u00ed\u00f0um gefur t\u00e6kif\u00e6ri til a\u00f0 breyta gir\u00f0ieiginleikum vi\u00f0komandi pept\u00ed\u00f0s vi\u00f0 m\u00e1lmj\u00f3nir. Alk\u00fdlun \u00e1 karbox\u00fdlh\u00f3p C-enda pept\u00ed\u00f0sins beinir gir\u00f0ingu m\u00e1lmj\u00f3narinnar \u00ed fj\u00f3rgirta \u03ba4[NH2,N,N,=O] fl\u00f3ka. Me\u00f0 st\u00fdringu \u00e1 samsetningu pept\u00ed\u00f0sins er h\u00e6gt a\u00f0 mynda kela\u00f0a hringi umhverfis m\u00e1lmj\u00f3nina \u00ed misst\u00f3rum hringjast\u00e6r\u00f0um; H\u00e6gt er a\u00f0 mynda fj\u00f3rgir\u00f0andi pept\u00ed\u00f0, \u03ba4[n,5,5] (\u00fear sem n = 5, 6, 7, e\u00f0a 8 at\u00f3m) me\u00f0 misst\u00f3rum hringjum \u00e1 hli\u00f0arke\u00f0ju N-endans sem lei\u00f0ir til mismunandi r\u00famfr\u00e6\u00f0ilegrar gir\u00f0ingar m\u00e1lmsins og v\u00e6ntanlega breytilegra efnaeiginleika. Fj\u00f6gur tr\u00edpept\u00ed\u00f0 me\u00f0 alk\u00fdla\u00f0a karbox\u00fdlh\u00f3pa voru sm\u00ed\u00f0u\u00f0, \u03b1-Asp(OtBu)AlaGly(OMe), \u03b2-Asp(OtBu)AlaGly(OMe), TrpAlaGly(OMe), HisAlaGly(OMe), og \u03b3-Glu(OMe)Cys(SMe)-Gly(OMe) til a\u00f0 mynda fl\u00f3ka me\u00f0 palladium og nikkel \u00ed fj\u00f3rgirtu umhverfi.<\/p>\n

Gir\u00f0ieiginleikar alk\u00fdlera\u00f0ra tr\u00edpept\u00ed\u00f0a var ranns\u00f6ku\u00f0 me\u00f0 spennut\u00edtrunum og NMR m\u00e6lingum \u00ed vatni. S\u00fdrustigsh\u00e1\u00f0 gir\u00f0ing tenglanna vi\u00f0 [Pd(en)(H2O)2]2+ var greind og fl\u00f3kar mynda\u00f0ir sta\u00f0festir byggt \u00e1 NMR-g\u00f6gnum. \u00dat fr\u00e1 \u00feessum ni\u00f0urst\u00f6\u00f0um voru tilraunir hanna\u00f0ar til a\u00f0 sm\u00ed\u00f0a Pd(II) fl\u00f3ka me\u00f0 tr\u00edpept\u00ed\u00f0unum \u03b1-Asp(OtBu)AlaGly(OMe), \u03b2-Asp(OtBu)AlaGly(OMe), og TrpAlaGly(OMe). \u00deessir fl\u00f3kar voru einangra\u00f0ir og greindir a\u00f0 fullu. Tenglarnir mynda \u00fer\u00ed- og fj\u00f3rgirta fl\u00f3ka me\u00f0 Pd(II). \u00der\u00edgirtu fl\u00f3karnir h\u00f6f\u00f0u fj\u00f3r\u00f0a tengilinn fr\u00e1 upphafsefninu. Skiptihv\u00f6rf \u00e1 \u00feessum fj\u00f3r\u00f0a tengli s\u00fdndu a\u00f0 h\u00e6gt v\u00e6ri a\u00f0 fjarl\u00e6gja r\u00e9tt valinn tengil og tr\u00edpept\u00ed\u00f0i\u00f0 mynda\u00f0i \u00fe\u00e1 fj\u00f3rgirt lokaefni me\u00f0 ferningslaga byggingu. Byggingar fl\u00f3kanna voru reikna\u00f0ar me\u00f0 DFT reikningum \u00fear sem kristalbyggingar fengust ekki. Hvarfgirni me\u00f0 litlum sameindum eins og ethylen, s\u00fdrum formati, og epis\u00falf\u00ed\u00f0i var sko\u00f0u\u00f0, en fl\u00f3karnir hv\u00f6rfu\u00f0ust ekki vi\u00f0 ethylene. \u00deeir brotna ni\u00f0ur \u00ed s\u00fdru og vi\u00f0 s\u00farar a\u00f0st\u00e6\u00f0ur. Asetaldeh\u00ed\u00f0 mynda\u00f0ist \u00ed hvarfi vi\u00f0 ethylene vi\u00f0 s\u00farar a\u00f0st\u00e6\u00f0ur. Pd(II) er mj\u00fak Lewis s\u00fdra og myndar au\u00f0veldlega s\u00falf\u00ed\u00f0; Pd-tr\u00edpept\u00ed\u00f0 fl\u00f3karinir t\u00f3ku au\u00f0veldlega brennistein fr\u00e1 epis\u00falf\u00ed\u00f0i og myndu\u00f0u alken vi\u00f0 hv\u00f6tunara\u00f0st\u00e6\u00f0ur. Hvar vi\u00f0 format leiddi til rof m\u00e1lmsins fr\u00e1 tenglinum og afoxun \u00ed Pd(0).<\/p>\n

Ni(II) fl\u00f3kar me\u00f0 tenglunum, \u03b1-Asp(OtBu)AlaGly(OMe), \u03b2-Asp(OtBu)AlaGly(Ome), og TrpAlaGly(OMe) voru sm\u00ed\u00f0a\u00f0ir og greinir me\u00f0 litr\u00f3fsgreiningum, frumefna og massagreiningum. Bygging fl\u00f3kanna var fundin \u00fat fr\u00e1 DFT-reikningum sem bj\u00f6gu\u00f0 ferningslaga fl\u00f3kar. Alk\u00fdlh\u00f3par tenglanna reyndust vi\u00f0kv\u00e6mari fyir s\u00fdrustigi \u00ed hv\u00f6rfum me\u00f0 Ni(II) en me\u00f0 Pd(II) og C-endi tr\u00edpept\u00ed\u00f0sins gekkst undir vatnsrof vi\u00f0 mildar a\u00f0st\u00e6\u00f0ur. Rafefnafr\u00e6\u00f0i fl\u00f3kanna var m\u00e6ld \u00ed vatni og s\u00fdndi \u00f3afturkr\u00e6fa heg\u00f0un fyrir alla \u00ferj\u00e1 fl\u00f3kana.<\/p>\n

Um doktorsefni\u00f0
<\/strong>Lindsey Monger \u00f3lst upp \u00ed Wyoming-fylki \u00ed Bandar\u00edkjunum. H\u00fan lauk B.Sc. gr\u00e1\u00f0u \u00ed efnafr\u00e6\u00f0i fr\u00e1 University of Wyoming \u00e1ri\u00f0 2010. H\u00fan h\u00f3f M.Sc. n\u00e1m vi\u00f0 Ruhr-Universit\u00e4t Bochum, \u00de\u00fdskalandi en skipti yfir \u00ed doktorsn\u00e1m vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2015 undir lei\u00f0s\u00f6gn Sigr\u00ed\u00f0ar Suman, pr\u00f3fessors vi\u00f0 Raunv\u00edsindadeild.<\/p>\n<\/div><\/div>\n","protected":false},"featured_media":4985,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2021-05-18T14:00:00+00:00","_phd_date_end":"2021-05-18T16:00:00+00:00","_phd_location":"Askja Stofa 132","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Efnasm\u00ed\u00f0ar sm\u00e1pept\u00ed\u00f0a, Pd(II) og Ni(II) komplexar og hagn\u00fdting \u00feeirra vi\u00f0 virkjun l\u00edtilla sameinda (Synthesis of Tripeptides, Pd(II) and Ni(II) Complexes and their Potential Use in Activation of Small Molecules)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_efnafraedi_lindsey_jean_monger","_phd_source_node_id":"374571","_phd_source_type":"vidburdir","_phd_member_id":744,"footnotes":""},"phd_school":[101,93],"phd_discipline":[102],"class_list":["post-6220","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-raunvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-efnafraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6220","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6220\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/4985"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6220"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6220"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6220"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}