{"id":6214,"date":"2026-10-19T09:48:38","date_gmt":"2026-10-19T09:48:38","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-liffraedi-iwona-teresa-myszor\/"},"modified":"2026-10-19T09:48:38","modified_gmt":"2026-10-19T09:48:38","slug":"doktorsvorn-i-liffraedi-iwona-teresa-myszor","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-liffraedi-iwona-teresa-myszor\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edffr\u00e6\u00f0i – Iwona Teresa Myszor"},"content":{"rendered":"
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Streymi:\u00a0 <\/strong>https:\/\/livestream.com\/hi\/doktorsvorniwonamyzsor<\/a><\/p>\n

Doktorsefni:<\/strong>\u00a0Iwona Teresa Myszor<\/p>\n

Heiti ritger\u00f0ar:<\/strong>\u00a0\u00c1hrif aroyl phen\u00edlened\u00edam\u00edna og \u00fer\u00fdstings\u00e1lags \u00e1 \u00f3n\u00e6mis\u00fe\u00e6tti lungna\u00feekjunnar (Effects of aroylated phenylenediamines and mechanical stress on lung epithelial immunity)<\/p>\n

Andm\u00e6lendur:<\/strong>
<\/strong>Dr. Henk P. Haagsman, pr\u00f3fessor vi\u00f0 Department Biomolecular Health Sciences, Utrecht University, Hollandi
Dr. Sif Hansd\u00f3ttir, yfirl\u00e6knir lungnal\u00e6kninga vi\u00f0 Landsp\u00edtala H\u00e1sk\u00f3lasj\u00fakrah\u00fas og a\u00f0junkt vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. Gu\u00f0mundur Hrafn Gu\u00f0mundsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Einnig \u00ed doktorsnefnd:
<\/strong>Dr. \u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands
Dr. Sigurbergur K\u00e1rason, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands og yfirl\u00e6knir gj\u00f6rg\u00e6slul\u00e6kninga \u00e1 Landsp\u00edtala H\u00e1sk\u00f3lasj\u00fakrah\u00fasi
Dr. Margr\u00e9t Helga \u00d6gmundsd\u00f3ttir, d\u00f3sent vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Anna D\u00f3ra S\u00e6\u00fe\u00f3rsd\u00f3ttir, pr\u00f3fessor og deildarforseti L\u00edf- og umhverfisv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands<\/p>\n

\u00c1grip<\/strong><\/p>\n

N\u00e1tt\u00farulegt \u00f3n\u00e6mi lungna\u00feekju myndar virkt varnarkerfi me\u00f0 seytingu \u00f6rverudrepandi pept\u00ed\u00f0a, myndun \u00fe\u00e9ttitengja og sj\u00e1lfs\u00e1ti. Varnarkerfi\u00f0 virkjast me\u00f0 \u00f6rvun vi\u00f0taka \u00ed \u00feekjunni og getur leitt til \u00feess a\u00f0 bakter\u00edum er eytt, \u00fe\u00e9ttni \u00feekjunnar aukist og a\u00f0 virkni leysikorna s\u00e9 \u00f6rvu\u00f0. Me\u00f0 \u00fev\u00ed a\u00f0 hafa \u00e1hrif \u00e1 bo\u00f0lei\u00f0ir fyrir n\u00e1tt\u00farulegt \u00f3n\u00e6mi me\u00f0 s\u00e9rh\u00e6f\u00f0um efnum m\u00e1 \u00f6rva kerfi\u00f0 til a\u00f0 verjast s\u00fdkingum. Notkun \u00e1 efnum sem \u00f6rva bo\u00f0lei\u00f0ir \u00feekjuvarna eru \u00e1hugaver\u00f0ur m\u00f6guleiki tengdur s\u00fdkingum en einnig \u00ed \u00f6ndunarv\u00e9latengdum lungnaska\u00f0a (\u00d6TL) til a\u00f0 hindra br\u00e1tt andnau\u00f0arheilkenni (BAH) sj\u00faklinga \u00ed \u00f6ndunarv\u00e9l.<\/p>\n

Markmi\u00f0 verkefnisins var a\u00f0 rannsaka \u00e1hrif n\u00fdrra \u00f6rvunarefna, aroylated phenylenediamin (APD) efna \u00e1 n\u00e1tt\u00farulegt \u00f3n\u00e6mi og sko\u00f0a \u00e1hrif \u00fer\u00fdstings og slit\u00e1lags \u00e1 \u00feekjuvarnakerfi\u00f0.
N\u00fd APD \u00f6rvunarefni HO53 og HO56 juku tj\u00e1ningu \u00f6rverudrepandi efna \u00ed lungna\u00feekju og dr\u00f3gu \u00far innr\u00e1s bakter\u00eda \u00ed \u00feekjufrumur. B\u00e6\u00f0i APD efnin s\u00fdndu samverkan me\u00f0 v\u00edtam\u00edn D fyrir \u00f6rvun \u00e1 CAMP cathelicidin geninu og HO53 virkja\u00f0i STAT3 umritunar\u00fe\u00e1ttinn \u00ed \u00feeirri \u00f6rvun. Me\u00f0h\u00f6ndlun \u00e1 skautu\u00f0um \u00feekjufrumum me\u00f0 HO53 styrkti \u00feekjuna og j\u00f3k sj\u00e1lfs\u00e1t. HO53 haf\u00f0i v\u00ed\u00f0t\u00e6k \u00e1hrif \u00e1 genatj\u00e1ningu \u00ed frumunum s\u00e9rstaklega tj\u00e1ningu umbreytiens\u00edma fyrir hist\u00f3na, en \u00f6rva\u00f0i jafnframt AMPK bo\u00f0lei\u00f0ina og virkja\u00f0i TFEB umritunar\u00fe\u00e1ttinn. \u00der\u00fdstings\u00e1lag \u00ed s\u00e9rh\u00f6nnu\u00f0u t\u00e6ki CPAD (e. cyclical pressure air-liquid device) haf\u00f0i \u00e1hrif \u00e1 \u00fatlit \u00feekjunnar og tj\u00e1ningu l\u00edfmerkja (e. biomarkers) fyrir \u00d6TL, BAH og b\u00f3lgumi\u00f0la. Fyrsta athugun s\u00fdnir a\u00f0 HO53 efni\u00f0 eykur \u00e1 b\u00f3lguvi\u00f0brag\u00f0 sem \u00f6rva\u00f0 haf\u00f0i veri\u00f0 me\u00f0 \u00fer\u00fdstings\u00e1lagi.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Iwona Teresa Myszor f\u00e6ddist \u00ed P\u00f3llandi 27. n\u00f3vember \u00e1ri\u00f0 1991. H\u00fan l\u00e6r\u00f0i l\u00edffr\u00e6\u00f0i vi\u00f0 Jagiellonian University \u00ed Krak\u00e1 og \u00fatskrifa\u00f0ist me\u00f0 BSc-gr\u00e1\u00f0u \u00e1ri\u00f0 2013 og meistaragr\u00e1\u00f0u \u00ed l\u00edfefnafr\u00e6\u00f0i \u00e1ri\u00f0 2015.\u00a0 A\u00f0 lokinni meistaragr\u00e1\u00f0u f\u00f3r Iwona til London \u00ed Erasmus Plus \u00fej\u00e1lfun vi\u00f0 Medical Research Council Centre for Molecular Bacteriology and Infection, vi\u00f0 Imperial College. \u00c1ri\u00f0 2016 var h\u00fan \u00e1 Institute of Pharmacology vi\u00f0 p\u00f3lsku v\u00edsinda-akadem\u00eduna \u00ed Krak\u00e1. Iwona h\u00f3f doktorsn\u00e1m \u00ed l\u00edffr\u00e6\u00f0i vi\u00f0 L\u00edf og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands \u00ed jan\u00faar 2017 og stunda\u00f0i ranns\u00f3knir s\u00ednar \u00e1 L\u00edfv\u00edsindasetri H\u00e1sk\u00f3la \u00cdslands.<\/p>\n<\/div><\/div>","protected":false},"featured_media":4979,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2021-02-05T13:00:00+00:00","_phd_date_end":"2021-02-05T15:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0arsalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"\u00c1hrif aroyl phen\u00edlened\u00edam\u00edna og \u00fer\u00fdstings\u00e1lags \u00e1 \u00f3n\u00e6mis\u00fe\u00e6tti lungna\u00feekjunnar (Effects of aroylated phenylenediamines and mechanical stress on lung epithelial immunity)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_liffraedi_iwona_teresa_myszor","_phd_source_node_id":"372691","_phd_source_type":"vidburdir","_phd_member_id":738,"footnotes":""},"phd_school":[96,93],"phd_discipline":[97],"class_list":["post-6214","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-lif-og-umhverfisvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-liffraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6214","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6214\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/4979"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6214"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6214"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6214"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}