{"id":6183,"date":"2026-10-19T09:48:36","date_gmt":"2026-10-19T09:48:36","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-zuzana-budkova\/"},"modified":"2026-10-19T09:48:36","modified_gmt":"2026-10-19T09:48:36","slug":"doktorsvorn-i-lif-og-laeknavisindum-zuzana-budkova","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-zuzana-budkova\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf- og l\u00e6knav\u00edsindum – Zuzana Budkov\u00e1"},"content":{"rendered":"
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Mi\u00f0vikudaginn 14. apr\u00edl ver Zuzana Budkova doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: Hlutverk non-coding RNA sameinda og utanfrumupr\u00f3teina \u00ed \u00feroskun og s\u00e9rh\u00e6fingu brj\u00f3stkirtilsfruma og \u00ed brj\u00f3stakrabbameinum. Functional role of non-coding RNAs and extracellular matrix proteins in developmental processes and breast cancer.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. Ya\u00ebl Nossent, lektor vi\u00f0 Leiden University \u00ed Hollandi, og dr. \u00d3lafur Eysteinn Sigurj\u00f3nsson, pr\u00f3fessor vi\u00f0 H\u00e1sk\u00f3lann \u00ed Reykjav\u00edk og forst\u00f6\u00f0uma\u00f0ur hj\u00e1 Bl\u00f3\u00f0bankanum.<\/p>\n

Umsj\u00f3narkennari og lei\u00f0beinandi var dr. \u00de\u00f3rarinn Gu\u00f0j\u00f3nsson og me\u00f0lei\u00f0beinendur voru dr. Gunnhildur \u00c1sta Traustad\u00f3ttir og dr. Bylgja Hilmarsd\u00f3ttir. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd Eir\u00edkur Steingr\u00edmsson, pr\u00f3fessor, J\u00f3n \u00de\u00f3r Berg\u00fe\u00f3rsson, lektor og Unnur \u00deorsteinsd\u00f3ttir, forst\u00f6\u00f0uma\u00f0ur hj\u00e1 \u00cdE.<\/p>\n

Engilbert Sigur\u00f0sson, pr\u00f3fessor og forseti L\u00e6knadeildar H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 12.00.<\/p>\n

Fj\u00f6ldatakm\u00f6rkun: Einungis 10 geta veri\u00f0 \u00ed salnum \u00e1 me\u00f0an \u00e1 doktorsv\u00f6rninni stendur. V\u00f6rninni ver\u00f0ur streymt:\u00a0<\/strong><\/p>\n

https:\/\/livestream.com\/hi\/doktorsvornzuzanabudkova<\/a><\/p>\n

\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n

Bandvefsumbreyting \u00feekjufruma (e. epithelial to mesenchymal transition, EMT) og \u00feekjuvefsumbreyting bandvefsfruma (e. mesenchymal to epithelial transition, MET) eru mikilv\u00e6gir ferlar \u00ed f\u00f3stur\u00feroska, grein\u00f3ttri formger\u00f0 vefja og \u00ed sj\u00fakd\u00f3mum \u00e1 bor\u00f0 vi\u00f0 krabbamein \u00fear sem \u00feeir hafa veri\u00f0 tengdir vi\u00f0 \u00edfarandi v\u00f6xt og meinvarpamyndun. Markmi\u00f0 verkefnisins var a\u00f0 rannsaka RNA sameindir sem ekki tj\u00e1 fyrir pr\u00f3teinum (e. non-coding RNAs) \u00ed EMT, MET og \u00ed grein\u00f3ttri formger\u00f0.\u00a0 Einnig var markmi\u00f0i\u00f0 a\u00f0 rannsaka hlutverk utanfrumupr\u00f3teina \u00ed heg\u00f0un og svipger\u00f0 brj\u00f3stakrabbameinsfruma og \u00ed n\u00fd\u00e6\u00f0amyndun. Ranns\u00f3knarm\u00f3deli\u00f0 bygg\u00f0i \u00e1 brj\u00f3st\u00feekjufrumul\u00ednunni D492 og d\u00f3tturl\u00ednum hennar. \u00cd verkefninu var s\u00fdnt fram \u00e1 a\u00f0 RNA sameindir fr\u00e1 DLK1-DIO3 genasv\u00e6\u00f0inu sem ekki tj\u00e1 fyrir pr\u00f3teinum \u00e1samt microRNA203a hafa hlutverk \u00ed grein\u00f3ttri formger\u00f0 og \u00ed krabbameinum \u00fear sem \u00feessar RNA sameindir gegna hlutverki \u00ed EMT\/MET. Jafnframt var s\u00fdnt fram \u00e1 hlutverk\u00a0 YKL-40 og ECM1 utanfrumupr\u00f3teinanna \u00ed brj\u00f3stakrabbameinum, skri\u00f0i \u00e6xlisfruma og \u00ed n\u00fd\u00e6\u00f0amyndun.<\/p>\n

Abstract<\/strong><\/p>\n

The epithelial-to-mesenchymal transition (EMT) and branching morphogenesis are two seemingly different; however, related, developmental processes occurring in the breast gland. EMT and its reverse process mesenchymal-to-epithelial transition (MET) are important processes during embryogenesis and in diseases, such as cancer, where evidence suggests that they mediate processes such as cell invasion and formation of metastasis. Branching morphogenesis is an essential developmental process that in the breast gland mostly takes place postnatally. Both processes are widely studied due to their importance in multiple fields. However, the involvement of non-coding RNAs in the regulation of gene expression during EMT and branching morphogenesis has recently been appreciated and is a challenging field of study. Increased understanding of branching morphogenesis is essential not only to know how the breast gland develops but also to understand the formation of breast cancer.<\/p>\n

The PhD thesis’s main research topic is non-coding RNAs and their role in branching morphogenesis and epithelial-to-mesenchymal transition in breast epithelial cells. The goal was to identify non-coding RNAs that govern cellular plasticity in the human mammary gland. The thesis’s secondary focus was identifying extracellular matrix proteins contributing to the cellular plasticity and tumorigenic properties of breast epithelial cells. The research was conducted on D492 – derived cell lines. The D492 cell lines represent a highly relevant and useful model to study biological concepts, including EMT, branching morphogenesis, and tumorigenic properties.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Zuzana Budkova er f\u00e6dd 21. j\u00fan\u00ed 1988 \u00ed Brno \u00ed T\u00e9kklandi. H\u00fan lauk Bs pr\u00f3fi \u00e1ri\u00f0 2012 fr\u00e1 Masaryk H\u00e1sk\u00f3lanum \u00ed sameindal\u00edffr\u00e6\u00f0i og erf\u00f0afr\u00e6\u00f0i og mastersgr\u00e1\u00f0u fr\u00e1 sama sk\u00f3la \u00e1ri\u00f0 2015. \u00c1 n\u00e1mst\u00edmanum var h\u00fan einnig \u00ed 6 m\u00e1na\u00f0a starfsn\u00e1mi \u00ed l\u00edffr\u00e6\u00f0i vi\u00f0 Amazonian H\u00e1sk\u00f3lann \u00ed Per\u00fa. Eftir \u00fatskrift, \u00e1ri\u00f0 2015 kom h\u00fan til \u00cdslands \u00ed tveggja m\u00e1na\u00f0a starfsn\u00e1m vi\u00f0 H\u00e1sk\u00f3la \u00cdslands og byrja\u00f0i \u00ed doktorsn\u00e1mi sama \u00e1r. Foreldrar Zuzana eru Pavel Maty\u00e1\u0161 and Katarina Maty\u00e1\u0161ov\u00e1. Zuzana er gift Jan Budka og eiga \u00feau tv\u00f6 b\u00f6rn, Doubravka Eyd\u00edsi og Mlada L\u00f3u.<\/p>\n<\/div><\/div>","protected":false},"featured_media":4942,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2021-04-14T12:00:00+00:00","_phd_date_end":"2021-04-14T15:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Hlutverk non-coding RNA sameinda og utanfrumupr\u00f3teina \u00ed \u00feroskun og s\u00e9rh\u00e6fingu brj\u00f3stkirtilsfruma og \u00ed brj\u00f3stakrabbameinum. 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