{"id":6181,"date":"2026-10-19T09:48:36","date_gmt":"2026-10-19T09:48:36","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-tannlaeknavisindum-venu-gopal-reddy-patlolla\/"},"modified":"2026-10-19T09:48:36","modified_gmt":"2026-10-19T09:48:36","slug":"doktorsvorn-i-tannlaeknavisindum-venu-gopal-reddy-patlolla","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-tannlaeknavisindum-venu-gopal-reddy-patlolla\/","title":{"rendered":"Doktorsv\u00f6rn i tannl\u00e6knav\u00edsindum – Venu Gopal Reddy Patlolla"},"content":{"rendered":"
\n
\n

F\u00f6studaginn 11. j\u00fan\u00ed ver Venu Gopal Reddy Patlolla\u00a0 doktorsritger\u00f0 s\u00edna \u00ed tannl\u00e6knav\u00edsindum vi\u00f0 Tannl\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: Sl\u00edmhimnuvi\u00f0lo\u00f0andi lyfjaform til me\u00f0h\u00f6ndlunar \u00e1 sta\u00f0bundnum sj\u00fakd\u00f3mum \u00ed munnholi. Mucoadhesive drug delivery systems for the treatment of oral mucosal conditions.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. David S. Jones, pr\u00f3fessor vi\u00f0 Queen\u2018s University \u00ed Belfast \u00e1 \u00cdrlandi og dr. Anna-Lena Kj\u00f8niksen, pr\u00f3fessor vi\u00f0 H\u00f8gskolen i \u00d8stfold \u00ed Noregi.<\/p>\n

Umsj\u00f3narkennari var dr. William Peter Holbrook, pr\u00f3fessor emeritus, og lei\u00f0beinendur voru dr. \u00de\u00f3rd\u00eds Kristmundsd\u00f3ttir, pr\u00f3fessor emeritus, og Sveinbj\u00f6rn Gizurarson, pr\u00f3fessor. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd dr. Jukka H. Meurman, pr\u00f3fessor og dr. Sk\u00fali Sk\u00falason, framkv\u00e6mdastj\u00f3ri.<\/p>\n

Bjarni Elvar P\u00e9tursson, pr\u00f3fessor og varadeildarforseti Tannl\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 9.00.<\/p>\n

V\u00f6rninni ver\u00f0ur streymt:\u00a0<\/p>\n

https:\/\/livestream.com\/hi\/doktorsvornvenugopalreddypatlolla<\/a><\/p>\n

\u00c1grip<\/strong><\/p>\n

Sl\u00edmhimna munnholsins er \u00fe\u00e6gilega sta\u00f0sett fyrir lyfjaform sem \u00e6tlu\u00f0 er til a\u00f0 me\u00f0h\u00f6ndla sta\u00f0bundna sj\u00fakd\u00f3ma og til a\u00f0 koma lyfjum inn \u00ed l\u00edkamann. H\u00fan b\u00fd\u00f0ur upp \u00e1 4-4000 sinnum meira gegndr\u00e6pi en h\u00fa\u00f0in, sem gerir hana tilvalda til a\u00f0 koma st\u00f3rum m\u00f3lik\u00falum sta\u00f0bundi\u00f0 e\u00f0a inn \u00ed l\u00edkamann. Mismunandi \u00e1stand getur einkennt sl\u00edmhimnu munnholsins eins og s\u00e1r e\u00f0a munnangur, \u00f3n\u00e6misfr\u00e6\u00f0ileg vandam\u00e1l, ofhyrning og s\u00fdkingar (s\u00fdklar eins og candida og v\u00edrusar (frunsur)). Sumir sj\u00fakd\u00f3mar \u00feurfa langt\u00edmame\u00f0fer\u00f0, sem getur leitt til \u00feolmyndunar. \u00dea\u00f0 er \u00fev\u00ed mikil \u00fe\u00f6rf \u00e1 a\u00f0 \u00fer\u00f3a n\u00fdjar \u00e1hrifar\u00edkar me\u00f0fer\u00f0ir sem minnka b\u00f3lgur og me\u00f0h\u00f6ndlar s\u00fdkingar. Fyrri kl\u00edn\u00edskar pr\u00f3fanir og in vitro \u00f6rverupr\u00f3fanir s\u00fdna a\u00f0 dox\u00fds\u00fdkl\u00edn er kj\u00f6ri\u00f0 lyf til a\u00f0 minnka v\u00edtahring b\u00f3lgu\u00e1standsins og n\u00fdtist m\u00f6gulega til a\u00f0 me\u00f0h\u00f6ndla sj\u00fakd\u00f3ma \u00ed munnholi. Monocaprin er l\u00edp\u00ed\u00f0 sem hefur s\u00fdnt sig a\u00f0 vera virkt gegn s\u00fdklum, sveppum og veirum. \u00dea\u00f0 er \u00e1hrifar\u00edkt gegn frunsum \u00e1samt dox\u00fds\u00fdkl\u00edni og me\u00f0fer\u00f0in lofa\u00f0i g\u00f3\u00f0u samanbori\u00f0 vi\u00f0 n\u00faverandi me\u00f0fer\u00f0ir. Vandinn er hins vegar s\u00e1 a\u00f0 dox\u00fds\u00fdkl\u00edn oxast og epimer\u00edserast og monocaprin ver\u00f0ur fyrir vatnsrofi og getur or\u00f0i\u00f0 fyrir acyl-migration \u00ed lausn og \u00fev\u00ed \u00fearf a\u00f0 auka st\u00f6\u00f0ugleika beggja efnanna \u00ed lyfjaforminu, s\u00e9rstaklega \u00ed vatnslausnum.<\/p>\n

A\u00f0almarkmi\u00f0 \u00feessa verkefnis snerist um a\u00f0 auka st\u00f6\u00f0ugleika virku efnanna dox\u00fds\u00fdkl\u00edns og monocaprins og auka st\u00f6\u00f0ugleika \u00feeirra \u00ed geli. Til a\u00f0 framkv\u00e6ma \u00feessa vinnu \u00feurfti a\u00f0 \u00fer\u00f3a vi\u00f0eigandi HPLC\/UPLC a\u00f0fer\u00f0 til a\u00f0 magn\u00e1kvar\u00f0a virku efnin. Lyfjae\u00f0lisfr\u00e6\u00f0ilegt mat \u00e1 lyfjaformunum var framkv\u00e6mt til a\u00f0 finna besta lyfjaformi\u00f0 fyrir sl\u00edmhimnu munnsins. Lyfjaformin voru einnig sko\u00f0u\u00f0 me\u00f0 tilliti til vi\u00f0lo\u00f0unargetu og formbreytinga til a\u00f0 auka vi\u00f0veru \u00ed munnholi og \u00fe\u00e6gindi fyrir sj\u00faklinginn. \u00dea\u00f0 n\u00e1\u00f0ist a\u00f0 auka st\u00f6\u00f0ugleika dox\u00fds\u00fdkl\u00edns \u00ed vatnslausn yfir fimm \u00e1ra t\u00edmabil. Gel sem innih\u00e9lt dox\u00fds\u00fdkl\u00edn og monocaprin var \u00fer\u00f3a\u00f0 og voru b\u00e6\u00f0i efnin st\u00f6\u00f0ug \u00ed allt a\u00f0 eitt \u00e1r vi\u00f0 4\u00b0C. M\u00edkr\u00f3agnir voru einnig \u00fer\u00f3a\u00f0ar til a\u00f0 auka geymslu\u00feol dox\u00fds\u00fdkl\u00edns vi\u00f0 25\u00b0C og filmur sem innih\u00e9ldu m\u00edkr\u00f3agnir s\u00fdndu auki\u00f0 geymslu\u00feol dox\u00fds\u00fdkl\u00edns vi\u00f0 herbergishita.<\/p>\n

Mismunandi filmur fyrir sl\u00edmhimnu munnholsins sem innih\u00e9ldu mismunandi fj\u00f6lli\u00f0ur og m\u00fdkingarefni voru sko\u00f0u\u00f0 m.t.t. \u00e1hrifa \u00e1 geymslu\u00feol dox\u00fds\u00fdkl\u00edns og \u00e1hrif efnanna \u00e1 e\u00f0lisfr\u00e6\u00f0ilega \u00fe\u00e6tti lyfjaformsins eins og styrk, \u00fer\u00fatnun, s\u00fdrustig, vi\u00f0lo\u00f0unargetu og losun lyfjanna me\u00f0 mismunandi losunarferlum, eins og hra\u00f0ri losun, var sko\u00f0u\u00f0. \u00c1hrif hentugra fj\u00f6lli\u00f0a og m\u00fdkingarefnis \u00e1 geymslu\u00feol dox\u00fds\u00fdkl\u00edns var skr\u00e1\u00f0. Val fj\u00f6lli\u00f0a eftir eiginleikum filmu er jafnframt sko\u00f0a\u00f0 \u00ed \u00feessu verkefni.<\/p>\n

\u00der\u00f3a\u00f0 var dox\u00fds\u00fdkl\u00edn lyfjaform, sem h\u00e9lst st\u00f6\u00f0ugt \u00ed fimm \u00e1r. St\u00f6\u00f0ugt gel sem inniheldur dox\u00fds\u00fdkl\u00edn og monocaprin var \u00fer\u00f3a\u00f0. N\u00e1kv\u00e6m magngreiningar-a\u00f0fer\u00f0 fyrir monocaprin, bygg\u00f0 \u00e1 HPLC, var \u00fer\u00f3u\u00f0. Dox\u00fds\u00fdkl\u00edn var st\u00f6\u00f0ga\u00f0 \u00ed munnholsfilmum sem innih\u00e9ldu m\u00edkr\u00f3agnir, jafnvel vi\u00f0 herbergishita. \u00c1hrif m\u00edkr\u00f3agna blanda\u00f0ra munnholsfilmum voru sko\u00f0a\u00f0ar m.t.t. eiginleika filmunnar. Hentugar fj\u00f6lli\u00f0ur fyrir dox\u00fds\u00fdkl\u00edn \u00ed munnholsfilmum voru sko\u00f0a\u00f0ar og eru kynntar. \u00deetta verkefni s\u00fdnir a\u00f0 h\u00e6gt er a\u00f0 st\u00f6\u00f0ga bl\u00f6ndu af dox\u00fds\u00fdkl\u00edn \u00ed lyfjaformum til a\u00f0 hindra MMP \u00ed sl\u00edmhimnum, sem einnig innihalda monocaprin, sem g\u00e6tu or\u00f0i\u00f0 marka\u00f0svara.<\/p>\n

English abstract<\/strong><\/p>\n

The oral mucosa is a convenient location where drug delivery systems could be employed to treat both local conditions as well as systemic delivery. It offers 4-4000 times more permeability relative to skin which makes it an ideal platform for delivering higher molecular weight compounds both for local as well as systemic delivery. The oral mucosa can be affected by some conditions that are local e.g., ulcerative conditions like aphthous ulcers, immunologically mediated conditions, hyperkeratosis and infections (bacterial, candida and virus (cold sores)). Some of these conditions require long-term clinical follow up which eventually could lead to drug resistance. There is a growing need to develop new treatments that are effective in reducing the inflammation and effectively treating the infections. Previous clinical trials and in vitro microbial tests proved that doxycycline is a promising alternative in downgrading the inflammation pathway and could be potentially useful in treatment of many oral conditions. Monocaprin is a lipid that is effective against various bacteria, yeast, and viruses. It effectively healed cold sores in combination with doxycycline and treatment outcome was promising compared to the existing treatments. But the drawback was the stability of the compounds; doxycycline undergoes oxidation and epimerization while monocaprin undergoes hydrolysis and is also susceptible for acyl-migration in solutions and both the compounds need to be stabilized in formulations especially sensitive to aqueous formulations. So, the main aim of this project was focused on enhancing the stability of active components doxycycline and monocaprin and stabilizing them in combination in a hydrogel formulation. The study also involved development of suitable HPLC\/UPLC method for accurate chemical quantification of the active component. Further the physicochemical evaluation of the formulations was analyzed to optimize the formulations for the oral mucosal delivery. The formulations were also analyzed for mucoadhesion capacity and texture profile analysis to enhance the drug retention at application site and to enhance the patient compliance. The doxycycline was successfully stabilized in aqueous formulation for a tested period of up to 5 years. A hydrogel containing combination of doxycycline and monocaprin was developed and both the active components were stabilized for a period up to 1 year at 4\u00b0C.\u00a0 The microparticles were further developed to enhance the doxycycline stability even at 25\u00b0C and films loaded with microparticles effectively stabilized doxycycline even at room temperature.<\/p>\n

Various buccal films with different polymeric blends and plasticizers were evaluated for their suitability for doxycycline stability and their effect on films, mechanical properties, swelling index, pH, mucoadhesive potential and in vitro release with varying release time profile ranging from immediate-intermediate-sustained films were developed and evaluated. Suitable polymers and plasticizers for doxycycline stability are reported. Selection of polymers based on film properties that can be tailored are discussed in this work.<\/p>\n

Overall, doxycycline formulation that is stable for 5 years was developed. A stable hydrogel containing combination of doxycycline and monocaprin was developed. An accurate HPLC method for monocaprin quantification was developed. Doxycycline was further stabilized in microparticles loaded buccal films even at room temperature. Effect of microparticles and their incorporation on doxycycline stability as well as film properties were evaluated. Suitable polymers and plasticizers for doxycycline, for buccal film development were studied and reported. This project successfully stabilized doxycycline in formulations, also in combination with monocaprin, that could deliver it for MMP inhibition for oral mucosa, were developed that could be commercially available.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Venu Gopal Reddy Patlolla f\u00e6ddist \u00ed Hyderabad \u00e1 Indlandi 15. september 1988. Hann lauk BS-pr\u00f3fi \u00ed lyfjafr\u00e6\u00f0i fr\u00e1 Osmania University \u00e1ri\u00f0 2010 og MS-pr\u00f3fi \u00ed lyfjav\u00edsindum fr\u00e1 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2014. Hann \u00e1kva\u00f0 a\u00f0 halda \u00e1fram og f\u00f3r \u00ed doktorsn\u00e1m vi\u00f0 Lyfjafr\u00e6\u00f0ideild og Tannl\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Hann starfar \u00ed dag vi\u00f0 \u00fer\u00f3un n\u00fdrra lyfjaforma hj\u00e1 Argenta Global \u00ed Kansas, Bandar\u00edkjunum. Foreldrar hans eru Buchi Reddy og Shamantha, fr\u00e1 Hyderabad. Hann er kv\u00e6ntur Shamini og eiga \u00feau d\u00f3tturina Myru.<\/p>\n<\/div><\/div>","protected":false},"featured_media":4940,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2021-06-11T09:00:00+00:00","_phd_date_end":"2021-06-11T13:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Sl\u00edmhimnuvi\u00f0lo\u00f0andi lyfjaform til me\u00f0h\u00f6ndlunar \u00e1 sta\u00f0bundnum sj\u00fakd\u00f3mum \u00ed munnholi. Mucoadhesive drug delivery systems for the treatment of oral mucosal conditions","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_tannlaeknavisindum_venu_gopal_reddy_patlolla","_phd_source_node_id":"375751","_phd_source_type":"vidburdir","_phd_member_id":700,"footnotes":""},"phd_school":[60,124],"phd_discipline":[125],"class_list":["post-6181","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-heilbrigdisvisindasvid","phd_school-tannlaeknadeild","phd_discipline-phd-i-tannlaeknavisindum"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6181","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6181\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/4940"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6181"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6181"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6181"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}