{"id":6174,"date":"2026-10-19T09:48:35","date_gmt":"2026-10-19T09:48:35","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-gudbjorg-jonsdottir\/"},"modified":"2026-10-19T09:48:35","modified_gmt":"2026-10-19T09:48:35","slug":"doktorsvorn-i-laeknavisindum-gudbjorg-jonsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-gudbjorg-jonsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – Gu\u00f0bj\u00f6rg J\u00f3nsd\u00f3ttir"},"content":{"rendered":"
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F\u00f6studaginn 21. ma\u00ed ver Gu\u00f0bj\u00f6rg J\u00f3nsd\u00f3ttir doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: L\u00fd\u00f0grundu\u00f0 ranns\u00f3kn \u00e1 \u00fer\u00f3un annarra krabbameina hj\u00e1 sj\u00faklingum me\u00f0 merg\u00e6xli: \u00c1h\u00e6ttu\u00fe\u00e6ttir og \u00e1hrif \u00e1 lifun. <\/strong>Second Malignancies in Patients with Multiple Myeloma: Risk Factors and Impact on Survival.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. Anette Vangsted, yfirl\u00e6knir \u00e1 Rigshospitalet \u00ed Kaupmannah\u00f6fn, og dr. Sign\u00fd Vala Sveinsd\u00f3ttir, yfirl\u00e6knir \u00e1 Bl\u00f3\u00f0sj\u00fakd\u00f3madeild LSH.<\/p>\n

Umsj\u00f3narkennari og lei\u00f0beinandi var dr. Sigur\u00f0ur Yngvi Kristinsson, pr\u00f3fessor. Auk hans s\u00e1tu \u00ed doktorsnefnd dr. Magn\u00fas Karl Magn\u00fasson, pr\u00f3fessor, dr. Anna Porwit, pr\u00f3fessor, dr. Magnus Bj\u00f6rkholm, pr\u00f3fessor og dr. Ola Landgren, pr\u00f3fessor.<\/p>\n

Engilbert Sigur\u00f0sson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 13.00.<\/p>\n

Fj\u00f6ldatakm\u00f6rkun: Einungis 50 manns geta veri\u00f0 \u00ed salnum \u00e1 me\u00f0an \u00e1 doktorsv\u00f6rninni stendur. <\/strong><\/p>\n

V\u00f6rninni ver\u00f0ur streymt: <\/strong>https:\/\/livestream.com\/hi\/doktorsvorngudbjorgjonsdottir<\/a><\/strong><\/p>\n

\u00c1grip<\/strong><\/p>\n

Merg\u00e6xli er illkynja sj\u00fakd\u00f3mur sem einkennist af fj\u00f6lgun einstofna plasmafrumna \u00ed beinmerg. Me\u00f0 tilkomu \u00e1hrifar\u00edkari lyfja \u00ed me\u00f0h\u00f6ndlun sj\u00faklinga me\u00f0 merg\u00e6xli s\u00ed\u00f0astli\u00f0na \u00e1ratugi hefur lifun \u00feeirra st\u00f3raukist. \u00deessi aukna lifun hefur leitt til aukinnar \u00e1herslu rannsakenda \u00e1 langt\u00edma aflei\u00f0ingum \u00ed formi \u00fer\u00f3un annarra krabbameina. Meginmarkmi\u00f0 doktorsverkefnisins var a\u00f0 kanna \u00e1hrif annarra krabbameina \u00e1 lifun sj\u00faklinga me\u00f0 merg\u00e6xli og leitast vi\u00f0 a\u00f0 kanna \u00e1h\u00e6ttu\u00fe\u00e6tti fyrir \u00fer\u00f3un \u00feeirra me\u00f0 s\u00e9rstaka \u00e1herslu \u00e1 br\u00e1\u00f0ahv\u00edtbl\u00e6\u00f0i og mergmis\u00feroska. Verkefni\u00f0 var byggt \u00e1 g\u00f6gnum fr\u00e1 s\u00e6nsku krabbameinsskr\u00e1nni.<\/p>\n

Ranns\u00f3knin leiddi \u00ed lj\u00f3s a\u00f0 me\u00f0fer\u00f0artengdir og erf\u00f0afr\u00e6\u00f0ilegir \u00fe\u00e6ttir eiga m\u00f6gulega \u00fe\u00e1tt \u00ed \u00fer\u00f3un annarra krabbameina hj\u00e1 sj\u00faklingum me\u00f0 merg\u00e6xli. A\u00f0 auki var \u00fer\u00f3un annars krabbameins tengd verri horfum. Ni\u00f0urst\u00f6\u00f0urnar undirstrika mikilv\u00e6gi \u00feess a\u00f0 greina \u00e1h\u00e6ttu\u00fe\u00e6tti og l\u00edffr\u00e6\u00f0ilega ferla sem valda \u00feessari \u00fer\u00f3un. \u00a0<\/p>\n

English abstract<\/strong><\/p>\n

Multiple myeloma is a malignant disorder characterized by clonal proliferation of plasma cells in the bone marrow. Over the past decades increased access to modern effective therapies has improved survival and clinical outcomes for patients with multiple myeloma. However, improved survival has led to concerns regarding long-term complications such as development of second malignancies. The overall aim of the thesis was to determine the impact of second malignancies on survival and identify risk factors for second malignancy development with focus on patients who develop acute myeloid leukemia and myelodysplastic syndrome using data from the Swedish Cancer Registry.<\/p>\n

The results suggest that treatment- and host-related factors might play a role in second malignancy development in patients with multiple myeloma. Additionally, development of second malignancies was associated with inferior survival.\u00a0 These findings highlight the importance of identification of risk factors as well as biological mechanisms that result in second malignancies in patients with multiple myeloma.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Gu\u00f0bj\u00f6rg J\u00f3nsd\u00f3ttir er f\u00e6dd \u00ed Reykjav\u00edk \u00feann 28. j\u00fal\u00ed 1984. H\u00fan lauk st\u00fadentspr\u00f3fi af N\u00e1tt\u00farufr\u00e6\u00f0ibraut fr\u00e1 Menntask\u00f3lanum vi\u00f0 Sund \u00e1ri\u00f0 2004 og emb\u00e6ttispr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands 2010. Samhli\u00f0a doktorsn\u00e1minu hefur Gu\u00f0bj\u00f6rg starfa\u00f0 sem s\u00e9rn\u00e1msl\u00e6knir, h\u00fan lauk s\u00e9rn\u00e1mi \u00ed almennum lyfl\u00e6kningum vi\u00f0 H\u00e1sk\u00f3lasj\u00fakrah\u00fasi\u00f0 \u00ed Iowa \u00ed Bandar\u00edkjunum \u00e1ri\u00f0 2019 og leggur n\u00fa stund \u00e1 s\u00e9rn\u00e1m \u00ed bl\u00f3\u00f0- og krabbameinsl\u00e6kningum vi\u00f0 sama h\u00e1sk\u00f3lasj\u00fakrah\u00fas. Foreldrar Gu\u00f0bjargar eru Margr\u00e9t Bj\u00f6rnsd\u00f3ttir hj\u00fakrunarfr\u00e6\u00f0ingur (1956-2019) og J\u00f3n Hrafnkelsson l\u00e6knir. Maki Gu\u00f0bjargar er \u00c1sgeir \u00de\u00f3r M\u00e1sson l\u00e6knir og eiga \u00feau b\u00f6rnin M\u00e1 og Margr\u00e9ti H\u00f6llu.<\/p>\n<\/div><\/div>","protected":false},"featured_media":4931,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2021-05-21T13:00:00+00:00","_phd_date_end":"2021-05-21T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"L\u00fd\u00f0grundu\u00f0 ranns\u00f3kn \u00e1 \u00fer\u00f3un annarra krabbameina hj\u00e1 sj\u00faklingum me\u00f0 merg\u00e6xli: \u00c1h\u00e6ttu\u00fe\u00e6ttir og \u00e1hrif \u00e1 lifun. 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