{"id":6142,"date":"2026-10-19T09:48:33","date_gmt":"2026-10-19T09:48:33","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-liffraedi-sean-michael-scully\/"},"modified":"2026-10-19T09:48:33","modified_gmt":"2026-10-19T09:48:33","slug":"doktorsvorn-i-liffraedi-sean-michael-scully","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-liffraedi-sean-michael-scully\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edffr\u00e6\u00f0i Sean Michael Scully"},"content":{"rendered":"
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Doktorsefni:<\/strong>\u00a0Sean Michael Scully<\/p>\n

Heiti ritger\u00f0ar:<\/strong>\u00a0Efnaskipti am\u00edn\u00f3s\u00fdra og skyldra efna hj\u00e1 Thermoanaerobacter tegundum (e. Amino Acid and Related Catabolism of Thermoanaerobacter Species)<\/p>\n

Andm\u00e6lendur:
<\/strong>Dr. Jessica Adams, v\u00edsindama\u00f0ur vi\u00f0 Aberystwyth University \u00ed Wales.
Dr. Pauline Vannier, s\u00e9rfr\u00e6\u00f0ingur hj\u00e1 Mat\u00eds ohf.<\/p>\n

Umsj\u00f3narkennari:<\/strong> Dr. Gu\u00f0mundur \u00d3li Hreggvi\u00f0sson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands og faglegur lei\u00f0togi hj\u00e1 Mat\u00eds ohf.<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. J\u00f3hann \u00d6rlygsson, pr\u00f3fessor vi\u00f0 H\u00e1sk\u00f3lann \u00e1 Akureyri.<\/p>\n

Einnig \u00ed doktorsnefnd:\u00a0<\/strong>Dr. \u00d3lafur Fri\u00f0j\u00f3nsson, faglegur lei\u00f0togi hj\u00e1 Mat\u00eds ohf.
<\/strong><\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Sn\u00e6bj\u00f6rn P\u00e1lsson, pr\u00f3fessor og varadeildarforseti L\u00edf- og umhverfisv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

\u00c1grip<\/strong><\/p>\n

S\u00e1 hluti l\u00edfe\u00f0lisfr\u00e6\u00f0i hitak\u00e6rra bakter\u00eda sem sn\u00fdr a\u00f0 pr\u00f3tein- og am\u00edn\u00f3s\u00fdruefnaskiptum hefur a\u00f0 mestu veri\u00f0 vanr\u00e6ktur \u00ed gegnum t\u00ed\u00f0ina \u00fer\u00e1tt fyrir m\u00f6guleika sem \u00ed \u00feeim felast \u00e1 svi\u00f0i l\u00edft\u00e6kni. Vi\u00f0 loftfirr\u00f0ar a\u00f0st\u00e6\u00f0ur krefjast margar pr\u00f3teinmyndandi am\u00edn\u00f3s\u00fdrur utana\u00f0komandi rafeinda\u00feega til \u00feess a\u00f0 \u00far ver\u00f0i orkufr\u00e6\u00f0ilega hagst\u00e6\u00f0ar a\u00f0st\u00e6\u00f0ur fyrir ni\u00f0urbroti\u00f0. Thermoanaerobacter og Caldanaerobacter stofnar sem r\u00e6kta\u00f0ir voru \u00e1 grein\u00f3ttum am\u00edn\u00f3s\u00fdrum (e. BCAAs) \u00fdmist \u00ed vi\u00f0urvist metanframlei\u00f0anda e\u00f0a \u00fe\u00ed\u00f3s\u00falfats framleiddu annars vegar samsvarandi grein\u00f3ttar fitus\u00fdrur (e. BCFA) og hins vegar bl\u00f6ndu af grein\u00f3ttum fitus\u00fdrum og samsvarandi grein\u00f3ttum alk\u00f3h\u00f3lum (e. BCOH). \u00deessi rafeinda\u00feegakerfi s\u00fdna mun \u00e1 rafeindafl\u00e6\u00f0i sem lei\u00f0ir af s\u00e9r framlei\u00f0slu mismunandi lokaafur\u00f0a. Ranns\u00f3knir sem framkv\u00e6mdar voru \u00e1 \u00e6ttkv\u00edslinni leiddu \u00ed lj\u00f3s mun \u00e1 ni\u00f0urbrotsmynstri am\u00edn\u00f3s\u00fdra og v\u00f6rpu\u00f0u lj\u00f3si \u00e1 a\u00f0 hva\u00f0a leyti stofnarnir eru pr\u00f3t\u00ednsundrandi, \u00fe\u00f3 svo a\u00f0 h\u00e6fnin til a\u00f0 brj\u00f3ta ni\u00f0ur grein\u00f3ttar am\u00edn\u00f3s\u00fdrur og mynda \u00far \u00feeim grein\u00f3ttar fitus\u00fdrur og alk\u00f3h\u00f3l vir\u00f0ist gilda um \u00fe\u00e1 alla. Hlutf\u00f6llin milli framleiddra grein\u00f3ttra alk\u00f3h\u00f3la og fitus\u00fdra eru hins vegar mj\u00f6g breytileg. Upphaflega var BCOH framlei\u00f0sluferli\u00f0 \u00f3lj\u00f3st en me\u00f0 notkun 13C-merktra grein\u00f3ttra am\u00edn\u00f3s\u00fdra og vi\u00f0b\u00e6ttra fitus\u00fdra (t.d. asetats, 3-met\u00fdl-1-b\u00fat\u00fdrats) var h\u00e6gt a\u00f0 s\u00fdna fram \u00e1 h\u00e6fni sumra Thermoanaerobacter og Caldanaerobacter stofna til \u00feess a\u00f0 n\u00fdta fitus\u00fdrurnar sem elektr\u00f3nu\u00feega og breyta \u00feeim \u00ed samsvarandi alk\u00f3h\u00f3l. Ranns\u00f3knir s\u00fdndu einnig a\u00f0 Thermoanaerobacter pseudoethanolicus og Thermoanaerobacter stofn AK85 megi n\u00fdta til l\u00edfummyndunar \u00e1 C2-C6 fitus\u00fdrum \u00ed samsvarandi alk\u00f3h\u00f3lsamb\u00f6nd \u00ed vi\u00f0urvist rafeindagjafa.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Sean Scully f\u00e6ddist \u00ed Bandar\u00edkjunum og stunda\u00f0i \u00fear n\u00e1m \u00ed efnafr\u00e6\u00f0i og l\u00edffr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3lann \u00ed Toledo, Ohio. Hann flutti til \u00cdslands \u00e1ri\u00f0 2008 og stunda\u00f0i BS-n\u00e1m \u00ed l\u00edft\u00e6kni vi\u00f0 H\u00e1sk\u00f3lann \u00e1 Akureyri og au\u00f0lindafr\u00e6\u00f0i, me\u00f0 \u00e1herslu \u00e1 l\u00edft\u00e6kni, vi\u00f0 sama sk\u00f3la. Sean b\u00fdr \u00e1 Nor\u00f0urlandi me\u00f0 fj\u00f6lskyldu sinni og n\u00fdtur \u00feess a\u00f0 vera \u00fati \u00ed n\u00e1tt\u00farunni.<\/p>\n

Vi\u00f0bur\u00f0ur \u00e1 facebook<\/a><\/strong><\/p>\n<\/div><\/div>","protected":false},"featured_media":2053,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-05-31T10:00:00+00:00","_phd_date_end":"2019-05-31T12:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0arsalur","_phd_admission":"Allir velkomnir","_phd_thesis_title":"Efnaskipti am\u00edn\u00f3s\u00fdra og skyldra efna hj\u00e1 Thermoanaerobacter tegundum (e. Amino Acid and Related Catabolism of Thermoanaerobacter Species)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_liffraedi_sean_michael_scully","_phd_source_node_id":"317033","_phd_source_type":"vidburdir","_phd_member_id":626,"footnotes":""},"phd_school":[96,93],"phd_discipline":[97],"class_list":["post-6142","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-lif-og-umhverfisvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-liffraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6142","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6142\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/2053"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6142"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6142"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6142"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}