{"id":6082,"date":"2026-10-19T09:48:27","date_gmt":"2026-10-19T09:48:27","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-efnafraedi-johanna-margret-gretarsdottir\/"},"modified":"2026-10-19T09:48:27","modified_gmt":"2026-10-19T09:48:27","slug":"doktorsvorn-i-efnafraedi-johanna-margret-gretarsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-efnafraedi-johanna-margret-gretarsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed efnafr\u00e6\u00f0i – J\u00f3hanna Margr\u00e9t Gr\u00e9tarsd\u00f3ttir"},"content":{"rendered":"
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Doktorsefni:<\/strong>\u00a0J\u00f3hanna Margr\u00e9t Gr\u00e9tarsd\u00f3ttir<\/p>\n

Heiti ritger\u00f0ar:<\/strong> Efnasm\u00ed\u00f0ar n\u00fdrra m\u00f3lybdenum-brennisteins komplexa: Hv\u00f6tunarvirkni \u00e1 umbreytingu s\u00fdan\u00ed\u00f0s \u00ed \u00fe\u00ed\u00f3s\u00fdanat og\u00a0in vitro\u00a0l\u00edffr\u00e6\u00f0ilegar ranns\u00f3knir (e. Syntheses of new molybdenum-sulfur complexes: Catalytic transformation of cyanide to thiocyanate, and in vitro biological studies.)<\/p>\n

Andm\u00e6lendur:<\/strong>
<\/strong>Dr. Celine J. Marmion, pr\u00f3fessor vi\u00f0 efnafr\u00e6\u00f0ideild Royal College of Surgeons, Dublin, \u00cdrlandi og dr.\u00a0Kostas Demadis, pr\u00f3fessor vi\u00f0 efnafr\u00e6\u00f0ideild H\u00e1sk\u00f3lans \u00e1 Kr\u00edt.<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. Sigr\u00ed\u00f0ur G. Suman, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Einnig \u00ed doktorsnefnd:
<\/strong>Dr. M\u00e1r M\u00e1sson, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands.
Dr. Ingvar H. \u00c1rnason, pr\u00f3fessor emeritus vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Birgir Hrafnkelsson, pr\u00f3fessor og varadeildarforseti Raunv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

\u00c1grip<\/strong><\/p>\n

Bl\u00e1s\u00fdra er hra\u00f0virkt og banv\u00e6nt eitur sem hefur lengi veri\u00f0 \u00feekkt. Tilvist bl\u00e1s\u00fdru \u00ed reykeitrunum hefur vaki\u00f0 athygli l\u00e6kna og bj\u00f6rgunarf\u00f3lks n\u00fdveri\u00f0, og aflei\u00f0ingar eiturverkana hennar veri\u00f0 kanna\u00f0ar. N\u00fdjir alfa-am\u00edn\u00f3 m\u00f3lybdenum-brennisteins komplexar voru sm\u00ed\u00f0a\u00f0ir sem m\u00f6guleg efni til a\u00f0 \u00fer\u00f3a ney\u00f0arme\u00f0fer\u00f0 gegn bl\u00e1s\u00fdrueitrun. Komplexarnir voru greindir me\u00f0 segul\u00f3mun, innrau\u00f0um titringsr\u00f3fum og rafeindar\u00f3fum, og m\u00f3lmassi \u00feeirra \u00e1kvar\u00f0a\u00f0ur me\u00f0 massar\u00f3fum og frumefnagreiningu. Hringstraumsspennurit voru skr\u00e1\u00f0 auk kristalbygginga tveggja efna. Kal\u00edum s\u00f6lt af \u00fereon\u00edn, ser\u00edn, me\u00fe\u00edon\u00edn, og leus\u00edn voru einangru\u00f0 \u00ed fyrsta skipti sem hvarfefni fyrir efnasm\u00ed\u00f0ar komplexanna. S\u00f6ltin voru greind me\u00f0 segul\u00f3mun og frumefnagreiningu.
Fl\u00f6skuh\u00e1ls \u00ed lyfja\u00fer\u00f3un hvata\u00f0ra lyfjame\u00f0fer\u00f0a me\u00f0 efnum bygg\u00f0um \u00e1 m\u00e1lmkomplexum felst oft \u00ed vatnsleysni og eiturverknunum auk annarra l\u00edfe\u00f0lisfr\u00e6\u00f0ilegra eiginleika. Komplexarnir hvata hvarf bl\u00e1s\u00fdru og \u00fe\u00ed\u00f3s\u00falfats til a\u00f0 mynda \u00fe\u00ed\u00f3s\u00fdanat og s\u00falf\u00edt in vitro. Hv\u00f6tunin er hra\u00f0virk og allt a\u00f0 60% af bl\u00e1s\u00fdrunni er umbreytt \u00e1 20 m\u00edn\u00fatum. Komplexarnir s\u00fdna jafnframt h\u00e1a vatnsleysni og litlar eiturverkanir samanbori\u00f0 vi\u00f0 \u00feekkt lyf. Frumutilraunir \u00e1 heg\u00f0un komplexanna in vitro s\u00fdna a\u00f0 komplexarnir fara inn \u00ed frumur og \u00fea\u00f0an inn \u00ed frumuhluta eins og kjarna og hvatbera.
Ni\u00f0urst\u00f6\u00f0ur lofa g\u00f3\u00f0u og s\u00fdna a\u00f0 komplexarnir eru g\u00f3\u00f0ir kand\u00eddatar fyrir frekari \u00fer\u00f3un \u00e1 ney\u00f0arme\u00f0fer\u00f0 gegn bl\u00e1s\u00fdrueitrun.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

J\u00f3hanna lauk BS gr\u00e1\u00f0u \u00ed efnafr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2013. Sama \u00e1r h\u00f3f h\u00fan framhaldsn\u00e1m \u00ed efnafr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands. Samhli\u00f0a doktorsn\u00e1minu hefur h\u00fan sinnt stundakennslu vi\u00f0 s\u00f6mu stofnun.
<\/strong><\/p>\n

Facebook vi\u00f0bur\u00f0ur<\/strong><\/a><\/p>\n<\/div><\/div>","protected":false},"featured_media":5284,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2018-12-14T14:00:00+00:00","_phd_date_end":"2018-12-14T17:00:00+00:00","_phd_location":"Askja Stofa 132","_phd_admission":"Fer fram \u00e1 ensku Allir velkomnir","_phd_thesis_title":"Efnasm\u00ed\u00f0ar n\u00fdrra m\u00f3lybdenum-brennisteins komplexa: Hv\u00f6tunarvirkni \u00e1 umbreytingu s\u00fdan\u00ed\u00f0s \u00ed \u00fe\u00ed\u00f3s\u00fdanat og in vitro l\u00edffr\u00e6\u00f0ilegar ranns\u00f3knir (e. Syntheses of new molybdenum-sulfur complexes: Catalytic transformation of cyanide to thiocyanate, and in vitro biological studies.)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_efnafraedi_johanna_margret_gretarsdottir","_phd_source_node_id":"313088","_phd_source_type":"vidburdir","_phd_member_id":463,"footnotes":""},"phd_school":[101,93],"phd_discipline":[102],"class_list":["post-6082","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-raunvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-efnafraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6082","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6082\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/5284"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6082"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6082"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}