{"id":6080,"date":"2026-10-19T09:48:27","date_gmt":"2026-10-19T09:48:27","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-efnafraedi-haraldur-yngvi-juliusson\/"},"modified":"2026-10-19T09:48:27","modified_gmt":"2026-10-19T09:48:27","slug":"doktorsvorn-i-efnafraedi-haraldur-yngvi-juliusson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-efnafraedi-haraldur-yngvi-juliusson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed efnafr\u00e6\u00f0i – Haraldur Yngvi J\u00fal\u00edusson"},"content":{"rendered":"
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Doktorsefni:<\/strong>\u00a0Haraldur Yngvi J\u00fal\u00edusson<\/p>\n

Heiti ritger\u00f0ar:<\/strong>\u00a0Framfarir \u00ed innlei\u00f0ingu st\u00edfra spunamerkja inn \u00ed kjarns\u00fdrur (Advancements in site-directed incorporation of rigid spin-labels into nucleic acids )<\/p>\n

Andm\u00e6lendur:<\/strong><\/p>\n

Dr. Stef\u00e1n J\u00f3nsson, teymisstj\u00f3ri hj\u00e1 Alvotech
Dr. Stefan Vogel, d\u00f3sent \u00ed nan\u00f3l\u00edfv\u00edsindum vi\u00f0 Syddansk Universitet, Danm\u00f6rku<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. Snorri \u00de\u00f3r Sigur\u00f0sson, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands<\/p>\n

Einnig \u00ed doktorsnefnd:<\/strong><\/p>\n

Dr. Gu\u00f0mundur G. Haraldsson, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands
Dr. M\u00e1r M\u00e1sson, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands
Dr. Benjam\u00edn Ragnar Sveinbj\u00f6rnsson, lektor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Oddur Ing\u00f3lfsson, pr\u00f3fessor og deildarforseti Raunv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands<\/p>\n

\u00c1grip<\/strong><\/p>\n

Rafeindasegullitr\u00f3fsgreiningu (e. Electron Paramagnetic Resonance, EPR) er reglubundi\u00f0 beitt \u00ed ranns\u00f3knum \u00e1 byggingu og hreyfingu kjarns\u00fdra til a\u00f0 f\u00e1 uppl\u00fdsingar um starfsemi \u00feeirra og hlutverk. Innlei\u00f0ing me\u00f0seglandi kjarna \u00e1 \u00e1kve\u00f0inn sta\u00f0 \u00ed kjarns\u00fdrum er nau\u00f0synleg fyrir EPR m\u00e6lingar og er \u00fea\u00f0 gert me\u00f0 a\u00f0fer\u00f0 sem kallast sta\u00f0bundin spunamerking. \u00deessi doktorsritger\u00f0 l\u00fdsir betrumb\u00f3tum \u00e1 sta\u00f0bundinni spunamerkingu \u00e1 kjarns\u00fdrum me\u00f0 notkun st\u00edfra spunamerkja. Fyrsti hluti ritger\u00f0arinnar l\u00fdsir \u00fer\u00f3un \u00e1 a\u00f0fer\u00f0 til verndunar n\u00edtrox\u00ed\u00f0-stakeinda til a\u00f0 koma \u00ed veg fyrir afoxun \u00feeirra \u00feegar spunamerktar kjarns\u00fdrur eru \u00fatb\u00fanar me\u00f0 efnasm\u00ed\u00f0i. Notast var vi\u00f0 bens\u00f3ylvernda\u00f0 h\u00fddroxylam\u00edn til verndunar \u00e1 n\u00edtrox\u00ed\u00f0inu. \u00deessi a\u00f0fer\u00f0 var notu\u00f0 til a\u00f0 innlei\u00f0a st\u00edfa spunamerki\u00f0 \u00c7 inn \u00ed DNA kjarns\u00fdrur og lofar g\u00f3\u00f0u sem almenn a\u00f0fer\u00f0 til \u00feess a\u00f0 innlei\u00f0a spunamerki \u00ed kjarns\u00fdrur me\u00f0 fosf\u00f3ram\u00ed\u00f0\u00edt-efnasm\u00ed\u00f0i. \u00cd \u00f6\u00f0rum hluta ritger\u00f0arinnar er efnasm\u00ed\u00f0i \u00e1 spunamerkjunum E\u00c7 og E\u00c7m l\u00fdst, en b\u00e6\u00f0i eru st\u00f6\u00f0ug vi\u00f0 afoxandi a\u00f0st\u00e6\u00f0ur. \u00deessi spunamerki eru \u00e6tlu\u00f0 til notkunar vi\u00f0 innan-fruma EPR m\u00e6lingar \u00e1 kjarns\u00fdrum. B\u00e6\u00f0i spunamerkin eru st\u00edf, sem gerir m\u00f6gulegt a\u00f0 f\u00e1 n\u00e1kv\u00e6mar uppl\u00fdsingar um byggingu og hreyfingu kjarns\u00fdra me\u00f0 EPR. E\u00c7 var innleitt \u00ed DNA og E\u00c7m \u00ed RNA me\u00f0 kjarns\u00fdruefnasm\u00ed\u00f0i. E\u00c7m afoxa\u00f0ist a\u00f0 hluta til \u00e1 me\u00f0an \u00e1 RNA sm\u00ed\u00f0inni st\u00f3\u00f0 en \u00fe\u00e1 afoxun var unnt a\u00f0 koma \u00ed veg fyrir me\u00f0 fyrrnefndri bens\u00f3yl verndun n\u00edtrox\u00ed\u00f0sins. S\u00fdnt var fram \u00e1 a\u00f0 E\u00c7 og E\u00c7m breyttu ekki byggingu DNA og RNA tv\u00edli\u00f0a. \u00deri\u00f0ji hluti ritger\u00f0arinnar l\u00fdsir efnasm\u00ed\u00f0um \u00e1 o-bens\u00f3kvin\u00f3n aflei\u00f0um af \u00eds\u00f3ind\u00f3l\u00edni og \u00fe\u00e9ttingu \u00feeirra me\u00f0 o-fen\u00fdlentv\u00edam\u00ednum til a\u00f0 mynda \u00eds\u00f3ind\u00f3l\u00edn-fenas\u00edn aflei\u00f0ur. \u00cd kj\u00f6lfari\u00f0 voru \u00fe\u00e6r oxa\u00f0ar \u00ed fenas\u00edn-tv\u00ed-N-ox\u00ed\u00f0 n\u00edtrox\u00ed\u00f0 og kanna\u00f0 hvort unnt v\u00e6ri\u00a0 a\u00f0 nota \u00fe\u00e6r til spunamerkinga \u00e1n samgildra tengja \u00e1 tv\u00edstrendum DNA og RNA kjarns\u00fdrum sem innihalda basalausar st\u00f6\u00f0ur. \u00d3seti\u00f0 fenas\u00edn-N,N-tv\u00edox\u00ed\u00f0 tetramet\u00fdl\u00eds\u00f3ind\u00f3l\u00edn n\u00edtrox\u00ed\u00f0 s\u00fdndi mikla s\u00e6kni \u00ed basalausa st\u00f6\u00f0u \u00ed DNA \u00e1 m\u00f3ti basanum C.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Haraldur Yngvi J\u00fal\u00edusson er f\u00e6ddur \u00ed Reykjav\u00edk \u00e1ri\u00f0 1989. Haraldur \u00fatskrifa\u00f0ist me\u00f0 B.Sc.-gr\u00e1\u00f0u \u00ed efnafr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2014 og h\u00f3f s\u00ed\u00f0an doktorsn\u00e1m vi\u00f0 sama sk\u00f3la \u00ed l\u00edfr\u00e6nni efnafr\u00e6\u00f0i undir handlei\u00f0slu dr. Snorra \u00de\u00f3rs Sigur\u00f0ssonar. Haraldur b\u00fdr \u00ed Mosfellsb\u00e6 \u00e1samt \u00d6rnu Albertsd\u00f3ttur og b\u00f6rnum \u00feeirra, Stefan\u00edu Lind (2012) og \u00c1g\u00fasti Erni (2013).<\/p>\n

Vi\u00f0bur\u00f0ur \u00e1 facebook<\/a><\/p>\n<\/div><\/div>","protected":false},"featured_media":1780,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2020-02-06T13:00:00+00:00","_phd_date_end":"2020-02-06T15:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0arsalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Framfarir \u00ed innlei\u00f0ingu st\u00edfra spunamerkja inn \u00ed kjarns\u00fdrur (Advancements in site-directed incorporation of rigid spin-labels into nucleic acids )","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_efnafraedi_haraldur_yngvi_juliusson","_phd_source_node_id":"335941","_phd_source_type":"vidburdir","_phd_member_id":453,"footnotes":""},"phd_school":[101,93],"phd_discipline":[102],"class_list":["post-6080","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-raunvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-efnafraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6080","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6080\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1780"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6080"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6080"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6080"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}