{"id":6076,"date":"2026-10-19T09:48:26","date_gmt":"2026-10-19T09:48:26","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-tolfraedi-erna-valdis-ivarsdottir\/"},"modified":"2026-10-19T09:48:26","modified_gmt":"2026-10-19T09:48:26","slug":"doktorsvorn-i-tolfraedi-erna-valdis-ivarsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-tolfraedi-erna-valdis-ivarsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed t\u00f6lfr\u00e6\u00f0i – Erna Vald\u00eds \u00cdvarsd\u00f3ttir"},"content":{"rendered":"
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V\u00f6rninni ver\u00f0ur streymt:\u00a0https:\/\/livestream.com\/hi\/doktorsvornernavaldis<\/a><\/p>\n

Doktorsefni:<\/strong>\u00a0Erna Vald\u00eds \u00cdvarsd\u00f3ttir<\/p>\n

Heiti ritger\u00f0ar:<\/strong>\u00a0T\u00f6lfr\u00e6\u00f0ia\u00f0fer\u00f0ir \u00ed v\u00ed\u00f0t\u00e6kum erf\u00f0amengisleitum (Statistical methods in genome-wide association studies)<\/p>\n

Andm\u00e6lendur:<\/strong> Dr. Mark Daly, forst\u00f6\u00f0uma\u00f0ur Institute of Molecular Medicine Finland (FIMM), University of Helsinki, og me\u00f0limur Broad Institute of MIT and Harvard.
Dr. Thor Aspelund, pr\u00f3fessor \u00ed l\u00edft\u00f6lfr\u00e6\u00f0i vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands og t\u00f6lfr\u00e6\u00f0ingur hj\u00e1 Hjartavernd.<\/p>\n

Lei\u00f0beinandi:<\/strong>\u00a0Dr. Dan\u00edel F. Gu\u00f0bjartsson, deildarstj\u00f3ri t\u00f6lfr\u00e6\u00f0ideildar \u00cdslenskrar erf\u00f0agreiningar<\/p>\n

Umsj\u00f3narkennari:<\/strong> Dr. Gunnar Stef\u00e1nsson, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Einnig \u00ed doktorsnefnd:<\/strong>
Dr. Bjarni V. Halld\u00f3rsson, h\u00f3pstj\u00f3ri erf\u00f0ara\u00f0agreiningar \u00cdslenskrar erf\u00f0agreiningar og d\u00f3sent vi\u00f0 H\u00e1sk\u00f3lann \u00ed Reykjav\u00edk.
<\/strong><\/p>\n

Doktorsv\u00f6rn st\u00fdrir:<\/strong>\u00a0Dr. Einar \u00d6rn Sveinbj\u00f6rnsson, pr\u00f3fessor og deildarforseti Raunv\u00edsindadeildar H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

\u00c1grip<\/strong><\/p>\n

Markmi\u00f0 v\u00ed\u00f0t\u00e6kra erf\u00f0amengisleita er a\u00f0 finna erf\u00f0abreytileika sem hafa \u00e1hrif \u00e1 mannlega eiginleika og sj\u00fakd\u00f3ma. Hinga\u00f0 til hafa v\u00ed\u00f0t\u00e6kar erf\u00f0amengisleitir lagt \u00e1herslu \u00e1 a\u00f0 finna erf\u00f0abreytileika sem hafa \u00e1hrif \u00e1 me\u00f0altal m\u00e6lanlegra eiginleika e\u00f0a \u00e1h\u00e6ttu \u00e1 sj\u00fakd\u00f3mum me\u00f0 \u00fev\u00ed a\u00f0 nota samleggjandi l\u00edkan. Breytileiki \u00ed erf\u00f0amenginu getur einnig haft \u00e1hrif \u00e1 mannlega eiginleika \u00e1 mismunandi h\u00e1tt, til d\u00e6mis me\u00f0 v\u00edkjandi h\u00e6tti e\u00f0a me\u00f0 \u00fev\u00ed a\u00f0 hafa \u00e1hrif \u00e1 dreifni m\u00e6lanlegra eiginleika \u00ed sta\u00f0 me\u00f0altals. \u00cd \u00feessari ritger\u00f0 eru notu\u00f0 mismunandi t\u00f6lfr\u00e6\u00f0il\u00edk\u00f6n til a\u00f0 finna erf\u00f0abreytileika sem hafa \u00e1hrif \u00e1 eiginleika hornhimnunnar og heyrn, \u00e1samt \u00fev\u00ed a\u00f0 rannsaka orsakasamb\u00f6nd milli tengdra svipger\u00f0a. Einnig eru \u00fatf\u00e6r\u00f0 dreifnil\u00edk\u00f6n til a\u00f0 finna samb\u00f6nd milli erf\u00f0abreytileika og dreifni m\u00e6lanlegra gilda og sko\u00f0um \u00e1hrif erf\u00f0abreytileika \u00e1 dreifni gl\u00fak\u00f3sa \u00ed bl\u00f3\u00f0i.<\/p>\n

\u00cd grein I voru metin \u00e1hrif 36 \u00feekktra gl\u00fak\u00f3sa erf\u00f0abreytileika \u00e1 dreifni gl\u00fak\u00f3sam\u00e6linga milli einstaklinga og innan einstaklinga. \u00cd lj\u00f3s kom a\u00f0 sumir erf\u00f0abreytileikar sem hafa \u00e1hrif \u00e1 me\u00f0altal gl\u00fak\u00f3sa hafa einnig \u00e1hrif \u00e1 dreifnina. Einnig s\u00e1st a\u00f0 erf\u00f0abreytileikar sem hafa \u00e1hrif \u00e1 auki\u00f0 me\u00f0altal af gl\u00fak\u00f3sa og aukna dreifni milli einstaklinga auka einnig l\u00edkur \u00e1 sykurs\u00fdki, \u00e1 me\u00f0an \u00feeir sem juku me\u00f0tali\u00f0 en dr\u00f3gu \u00far dreifni hafa ekki \u00e1hrif \u00e1 sykurs\u00fdki. Einnig var s\u00fdnt fram \u00e1 a\u00f0 erf\u00f0abreytileikar sem auka dreifni gl\u00fak\u00f3sa milli einstaklinga b\u00faa til fylgni milli skyldra einstaklinga og hafa \u00fear af lei\u00f0andi \u00e1hrif \u00e1 mat \u00e1 arfgengni.<\/p>\n

\u00cd grein II var framkv\u00e6md v\u00ed\u00f0t\u00e6k erf\u00f0amengisleit fyrir hornhimnum\u00e6lingar og fundust 7 erf\u00f0abreytileikar sem voru \u00e1\u00f0ur \u00f3\u00feekktir. Einn af \u00feeim er erf\u00f0abreytileiki n\u00e1l\u00e6gt ANAPC1 sem hefur veruleg \u00e1hrif \u00e1 frumu\u00fe\u00e9ttleika \u00ed inn\u00feekju hornhimnunnar og \u00fatsk\u00fdrir fj\u00f3r\u00f0ung af heildardreifni frumu\u00fe\u00e9ttleika \u00ed \u00fe\u00fd\u00f0inu. \u00deessi erf\u00f0abreytileiki hefur hins vegar ekki \u00e1hrif \u00e1 hornhimnusj\u00fakd\u00f3ma e\u00f0a gl\u00e1ku \u00ed okkar g\u00f6gnum, sem s\u00fdnir a\u00f0 \u00fer\u00e1tt fyrir fylgni milli frumu\u00fe\u00e9ttleika inn\u00feekjunnar og augnsj\u00fakd\u00f3ma veldur l\u00edtill frumu\u00fe\u00e9ttleiki ekki auknum l\u00edkum \u00e1 \u00feessum augnsj\u00fakd\u00f3mum.<\/p>\n

\u00cd grein III var framkv\u00e6md safnranns\u00f3kn v\u00ed\u00f0t\u00e6kra erf\u00f0amengisleita \u00e1 aldurstengdri heyrnarsker\u00f0ingu \u00fear sem notu\u00f0 voru b\u00e6\u00f0i samleggjandi og v\u00edkjandi l\u00edk\u00f6n. 22 \u00e1\u00f0ur \u00f3\u00feekktir erf\u00f0abreytileikar fundust, \u00fear af 14 sjaldg\u00e6fir. Sex af \u00e1\u00f0ur \u00f3\u00feekktu erf\u00f0abreytileikunum hafa \u00e1hrif \u00e1 aldurstengda heyrnarsker\u00f0ingu me\u00f0 v\u00edkjandi h\u00e6tti. Reikna\u00f0 var fj\u00f6lgena \u00e1h\u00e6ttuskor \u00fat fr\u00e1 algengu erf\u00f0abreytileikunum og s\u00fdnt a\u00f0 einstaklingar \u00ed efstu t\u00edund \u00e1h\u00e6ttuskorsins f\u00e1 aldurstengda heyrnarsker\u00f0ingu a\u00f0 me\u00f0altali 10 \u00e1rum fyrr en \u00feeir sem er \u00ed ne\u00f0stu t\u00edund \u00e1h\u00e6ttuskorsins. Einnig s\u00e1st a\u00f0 \u00e1h\u00e6tta \u00feeirra sem eru \u00ed efstu t\u00edund \u00e1h\u00e6ttuskorsins er samb\u00e6rileg \u00e1h\u00e6ttu \u00feeirra sem hafa sjaldg\u00e6far st\u00f6kkbreytingar sem valda aldurstengdri heyrnarsker\u00f0ingu en sjaldg\u00e6fu erf\u00f0abreytileikarnir valda \u00fe\u00f3 verri heyrnarsker\u00f0ingu en \u00feeir algengu.<\/p>\n

Ni\u00f0urst\u00f6\u00f0ur \u00feessara ranns\u00f3kna varpa n\u00fdju lj\u00f3si \u00e1 erf\u00f0afr\u00e6\u00f0i gl\u00fak\u00f3sa \u00ed bl\u00f3\u00f0i, inn\u00feekju hornhimnunnar og aldurstengdrar heyrnarsker\u00f0ingar, \u00e1samt \u00fev\u00ed a\u00f0 s\u00fdna fram \u00e1 mikilv\u00e6gi \u00feess a\u00f0 nota fj\u00f6lbreytt t\u00f6lfr\u00e6\u00f0il\u00edk\u00f6n til a\u00f0 meta \u00e1hrif erf\u00f0abreytileika \u00e1 svipger\u00f0ir.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Erna Vald\u00eds er f\u00e6dd \u00ed Reykjav\u00edk \u00e1ri\u00f0 1990. H\u00fan lauk st\u00fadentspr\u00f3fi fr\u00e1 Menntask\u00f3lanum \u00ed Reykjav\u00edk \u00e1ri\u00f0 2010, BS-pr\u00f3fi \u00ed str\u00e6\u00f0fr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2013 og MSc-pr\u00f3fi \u00ed t\u00f6lfr\u00e6\u00f0i fr\u00e1 Imperial College London \u00e1ri\u00f0 2014. Erna vann doktorsverkefni\u00f0 hj\u00e1 \u00cdslenskri erf\u00f0agreiningu \u00fear sem h\u00fan hefur starfa\u00f0 fr\u00e1 \u00e1rinu 2014.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1763,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2020-11-25T14:00:00+00:00","_phd_date_end":"2020-11-25T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0arsalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"T\u00f6lfr\u00e6\u00f0ia\u00f0fer\u00f0ir \u00ed v\u00ed\u00f0t\u00e6kum erf\u00f0amengisleitum (Statistical methods in genome-wide association studies)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_tolfraedi_erna_valdis_ivarsdottir","_phd_source_node_id":"370301","_phd_source_type":"vidburdir","_phd_member_id":446,"footnotes":""},"phd_school":[101,93],"phd_discipline":[104],"class_list":["post-6076","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-raunvisindadeild","phd_school-verkfraedi-og-natturuvisindasvid","phd_discipline-phd-i-tolfraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6076","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/6076\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1763"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=6076"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=6076"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=6076"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}