{"id":5999,"date":"2026-10-19T09:48:21","date_gmt":"2026-10-19T09:48:21","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-sigrun-thorsteinsdottir\/"},"modified":"2026-10-19T09:48:21","modified_gmt":"2026-10-19T09:48:21","slug":"doktorsvorn-i-laeknavisindum-sigrun-thorsteinsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-sigrun-thorsteinsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum &#8211; Sigr\u00fan \u00deorsteinsd\u00f3ttir"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p><strong>Fr\u00e9ttatilkynning vegna doktorsvarnar<\/strong><\/p>\n<p>F\u00f6studaginn 20. september ver Sigr\u00fan \u00deorsteinsd\u00f3ttir doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>Beinasj\u00fakd\u00f3mur hj\u00e1 sj\u00faklingum me\u00f0 merg\u00e6xli og forstig \u00feess og lifun \u00feeirra eftir greiningu sj\u00fakd\u00f3msins. Bone Disease and Survival in Multiple Myeloma and its Precursor.<\/strong><strong>\u00a0<\/strong><\/p>\n<p>Andm\u00e6lendur eru dr. Annette Juul Vangsted, yfirl\u00e6knir \u00e1 bl\u00f3\u00f0l\u00e6kningadeild R\u00edkissp\u00edtalans \u00ed Kaupmannah\u00f6fn, og dr. Sign\u00fd Vala Sveinsd\u00f3ttir, s\u00e9rfr\u00e6\u00f0il\u00e6knir \u00ed bl\u00f3\u00f0l\u00e6kningum vi\u00f0 Bl\u00f3\u00f0l\u00e6kningadeild Landsp\u00edtala.<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var dr. Sigur\u00f0ur Yngvi Kristinsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild. Auk hans s\u00e1tu \u00ed doktorsnefnd dr. Gunnar Sigur\u00f0sson, pr\u00f3fessor emeritus vi\u00f0 L\u00e6knadeild, dr. Vilmundur Gu\u00f0nason, forst\u00f6\u00f0ul\u00e6knir Hjartaverndar, og dr. Ola Landgren, pr\u00f3fessor og yfirl\u00e6knir vi\u00f0 Memorial Sloan Kettering sj\u00fakrah\u00fasi\u00f0 \u00ed New York.<\/p>\n<p>Engilbert Sigur\u00f0sson, pr\u00f3fessor og forseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 13:00.<\/p>\n<p><strong><\/strong><\/p>\n<p><strong><\/strong><\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n<p>Merg\u00e6xli er illkynja sj\u00fakd\u00f3mur sem einkennist af stj\u00f3rnlausri skiptingu plasmafrumna \u00ed beinmerg. N\u00e6r \u00f6ll tilfelli merg\u00e6xlis koma \u00ed kj\u00f6lfar \u00feess er kallast forstig merg\u00e6xlis (g\u00f3\u00f0kynja einstofna m\u00f3tefnah\u00e6kkun; monoclonal gammopathy of undetermined significance, MGUS). Merg\u00e6xli veldur beina\u00far\u00e1tum og beinbrotum og t\u00ed\u00f0ni beinbrota er einnig aukin hj\u00e1 einstaklingum me\u00f0 forstig merg\u00e6xlis. Markmi\u00f0 doktorsverkefnisins var a\u00f0 sko\u00f0a beinasj\u00fakd\u00f3m og lifun sj\u00faklinga me\u00f0 merg\u00e6xli og forstig \u00feess. Verkefninu var skipt \u00ed \u00ferj\u00e1 hluta. \u00cd fyrsta hluta \u00feess var bein\u00fe\u00e9ttni \u00ed einstaklingum me\u00f0 forstig merg\u00e6xlis sko\u00f0u\u00f0. \u00cd \u00f6\u00f0rum hluta verkefnisins var lifun hj\u00e1 sj\u00faklingum me\u00f0 mergfrumu\u00e6xli \u00ed Sv\u00ed\u00fej\u00f3\u00f0 \u00e1 \u00e1runum 1973-2013 sko\u00f0u\u00f0 mi\u00f0a\u00f0 vi\u00f0 lifun \u00ed almennu \u00fe\u00fd\u00f0i (hlutfallsleg lifun). \u00cd \u00feri\u00f0ja hluta verkefnisins var sj\u00f3num beint a\u00f0 tengslum beinbrota og lifunar hj\u00e1 merg\u00e6xlissj\u00faklingum. Ni\u00f0urst\u00f6\u00f0ur fyrsta hluta verkefnisins benda til \u00feess a\u00f0 bein\u00fe\u00e9ttni s\u00e9 ekki l\u00e6gri \u00ed einstaklingum me\u00f0 forstig merg\u00e6xlis, en a\u00f0 beinast\u00e6r\u00f0 s\u00e9 aukin. \u00cd \u00f6\u00f0rum hluta verkefnisins var s\u00fdnt fram \u00e1 a\u00f0 l\u00edfsl\u00edkur merg\u00e6xlissj\u00faklinga \u00ed \u00f6llum aldursflokkum upp a\u00f0 80 \u00e1ra aldri vi\u00f0 greiningu hafa aukist miki\u00f0 samhli\u00f0a \u00fev\u00ed a\u00f0 n\u00fdjum lyfjame\u00f0fer\u00f0um hefur veri\u00f0 beitt. A\u00f0 lokum s\u00fdndu ni\u00f0urst\u00f6\u00f0ur \u00feri\u00f0ja hluta ranns\u00f3knarinnar a\u00f0 sj\u00faklingar sem hlj\u00f3ta beinbrot eftir greiningu merg\u00e6xlis eru \u00ed tv\u00f6faldri h\u00e6ttu \u00e1 dau\u00f0a. \u00deessar ni\u00f0urst\u00f6\u00f0ur undirstrika alvarleika beinbrota hj\u00e1 merg\u00e6xlissj\u00faklingum. \u00a0<strong>\u00a0<\/strong><\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Multiple myeloma (MM) is a malignant disorder characterized by an uncontrolled proliferation of plasma cells in the bone marrow. MM is preceded by the precursor condition monoclonal gammopathy of undetermined significance (MGUS). MM causes lytic bone lesions and fractures, and individuals with MGUS have an increased risk of fractures. The project was divided into three parts. The aim of the first part was to compare bone mineral density (BMD) in individuals with MGUS with individuals without MGUS. The aim of the second part was to analyze relative survival in MM in Sweden during 1972-2013. The aim of the third part was to analyze the association of fractures on survival after MM diagnosis. Results from the first part of the project indicate that although individuals with MGUS do not have a decreased BMD, bone volume is increased. In the second part it was demonstrated that increased use of novel agents in MM patients improved survival in MM patients dramatically. Analysis on the association of fractures and survival in MM showed that MM patients that developed a fracture after the time of diagnosis were at twofold increased risk of dying compared to MM patients without a fracture. These results stress the importance of bone disease in MM.<\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>Sigr\u00fan \u00deorsteinsd\u00f3ttir er f\u00e6dd \u00e1ri\u00f0 1986. H\u00fan lauk st\u00fadentspr\u00f3fi fr\u00e1 Menntask\u00f3lanum vi\u00f0 Hamrahl\u00ed\u00f0 \u00e1ri\u00f0 2006 og kand\u00eddatspr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 Kaupmannahafnah\u00e1sk\u00f3la \u00e1ri\u00f0 2014. H\u00fan hefur starfa\u00f0 sem l\u00e6knir \u00e1 lyfl\u00e6kningasvi\u00f0i Landsp\u00edtala fr\u00e1 \u00e1rinu 2015 samhli\u00f0a doktorsn\u00e1minu. Sigr\u00fan er n\u00fa a\u00f0 hefja st\u00f6rf sem n\u00fddoktor vi\u00f0 ranns\u00f3knina Bl\u00f3\u00f0skimun til bjargar. Foreldrar Sigr\u00fanar eru Gu\u00f0laug Magn\u00fasd\u00f3ttir f\u00e9lagsr\u00e1\u00f0gjafi (1948-2014) og \u00deorsteinn Helgason sagnfr\u00e6\u00f0ingur. B\u00f6rn Sigr\u00fanar eru tv\u00edburarnir Gu\u00f0j\u00f3n P\u00e9tur \u00deorkelsson og Helga Matthildur \u00deorkelsd\u00f3ttir sem eru 6 \u00e1ra g\u00f6mul.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1212,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-09-20T13:00:00+00:00","_phd_date_end":"2019-09-20T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Beinasj\u00fakd\u00f3mur hj\u00e1 sj\u00faklingum me\u00f0 merg\u00e6xli og forstig \u00feess og lifun \u00feeirra eftir greiningu sj\u00fakd\u00f3msins. Bone Disease and Survival in Multiple Myeloma and its Precursor","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_laeknavisindum_sigrun_thorsteinsdottir","_phd_source_node_id":"323495","_phd_source_type":"vidburdir","_phd_member_id":207,"footnotes":""},"phd_school":[60,67],"phd_discipline":[69],"class_list":["post-5999","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-heilbrigdisvisindasvid","phd_school-laeknadeild","phd_discipline-phd-i-laeknavisindum"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5999","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5999\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1212"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=5999"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=5999"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=5999"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}