{"id":5997,"date":"2026-10-19T09:48:21","date_gmt":"2026-10-19T09:48:21","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-samuel-sigurdsson\/"},"modified":"2026-10-19T09:48:21","modified_gmt":"2026-10-19T09:48:21","slug":"doktorsvorn-i-laeknavisindum-samuel-sigurdsson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-samuel-sigurdsson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum – Sam\u00fael Sigur\u00f0sson"},"content":{"rendered":"
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M\u00e1nudaginn 10. desember ver Sam\u00fael Sigur\u00f0sson doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: \u00c1hrif b\u00f3lusetningar me\u00f0 pr\u00f3tein-tengdu pneum\u00f3kokka b\u00f3luefni \u00e1 pneum\u00f3kokka \u00ed nefkoki og s\u00fdkingar af v\u00f6ldum pneum\u00f3kokka \u00ed \u00edslenskum b\u00f6rnum. The impact of vaccination with conjugated pneumococcal vaccine on pneumococcal carriage and disease caused by pneumococci in Icelandic children.<\/p>\n

Andm\u00e6lendur eru dr. Adam Finn, pr\u00f3fessor \u00ed barnal\u00e6kningum vi\u00f0 H\u00e1sk\u00f3lann \u00ed Bristol, og dr. Richard Malley, pr\u00f3fessor vi\u00f0 Harvard-h\u00e1sk\u00f3la \u00ed Boston.<\/p>\n

Umsj\u00f3narkennari var dr. \u00c1sgeir Haraldsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands, og lei\u00f0beinandi dr. Karl G. Kristinsson, pr\u00f3fessor vi\u00f0 s\u00f6mu deild. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd Birgir Hrafnkelsson, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild, Helga Erlendsd\u00f3ttir, a\u00f0j\u00fankt vi\u00f0 L\u00e6knadeild, og \u00de\u00f3r\u00f3lfur Gu\u00f0nason s\u00f3ttvarnal\u00e6knir.<\/p>\n

Engilbert Sigur\u00f0sson, pr\u00f3fessor og forseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed Ver\u00f6ld – H\u00fasi Vigd\u00edsar, stofu VHV-023, og hefst kl. 13:00.<\/p>\n

\u00c1grip af ranns\u00f3kn <\/strong><\/p>\n

Streptococcus pneumoniae, pneum\u00f3kokkar, eru \u00e1 me\u00f0al algengustu bakter\u00eda sem valda mi\u00f0eyrnab\u00f3lgu og lungnab\u00f3lgu \u00ed b\u00f6rnum og geta valdi\u00f0 alvarlegum \u00edfarandi s\u00fdkingum eins og heilahimnub\u00f3lgu og bl\u00f3\u00f0eitrun. B\u00f3lusetning gegn t\u00edu algengustu, meinvirkustu og\/e\u00f0a s\u00fdklalyfja\u00f3n\u00e6mustu hj\u00fapger\u00f0unum var b\u00e6tt \u00ed ungbarnab\u00f3lusetningar \u00e1 \u00cdslandi \u00e1ri\u00f0 2011.<\/p>\n

Markmi\u00f0 ranns\u00f3knarinnar var a\u00f0 meta \u00e1hrif b\u00f3lusetningarinnar \u00e1 berahlutfall pneum\u00f3kokka og \u00e1 s\u00fdkingar af v\u00f6ldum \u00feeirra \u00ed b\u00f3lusettum \u00edslenskum b\u00f6rnum samanbori\u00f0 vi\u00f0 fyrri \u00e1rganga.<\/p>\n

\u00cd ranns\u00f3kn I var nefkokss\u00fdnum safna\u00f0 \u00e1rlega \u00e1 \u00e1runum 2009 til 2015 fr\u00e1 b\u00f6rnum \u00far leiksk\u00f3lum \u00e1 h\u00f6fu\u00f0borgar-sv\u00e6\u00f0inu. \u00cd ranns\u00f3kn II var notast vi\u00f0 heilsug\u00e6slugagnagrunn Landl\u00e6knis og allar heilsug\u00e6slukomur barna vegna mi\u00f0eyrnab\u00f3lgu fr\u00e1 2005 til 2015 voru metnar. \u00cd ranns\u00f3kn III voru allar komur vegna \u00f6ndunarf\u00e6ras\u00fdkinga \u00e1 br\u00e1\u00f0am\u00f3tt\u00f6ku barna fr\u00e1 2008 til 2013 sko\u00f0a\u00f0ar. \u00cd ranns\u00f3kn IV voru allar innlagnir \u00e1 Barnasp\u00edtala Hringsins fr\u00e1 2005 til 2015 metnar.<\/p>\n

Fr\u00e1 upphafi b\u00f3lusetningarinnar hefur berahlutfall b\u00f3luefnishj\u00fapger\u00f0a l\u00e6kka\u00f0 um 94% \u00ed leiksk\u00f3lab\u00f6rnum. Berahlutfall annara minna meinvirkra hj\u00fapger\u00f0a hefur aukist og hefur \u00fev\u00ed heildarberahlutfall pneum\u00f3kokka haldist st\u00f6\u00f0ugt. S\u00fdklalyfja\u00f3n\u00e6mum pneum\u00f3kokkum hefur f\u00e6kka\u00f0 \u00ed \u00edslenskum leiksk\u00f3lab\u00f6rnum. Komum \u00e1 heilsug\u00e6slur og \u00e1 br\u00e1\u00f0am\u00f3tt\u00f6ku barna vegna eyrnab\u00f3lgu hefur f\u00e6kka\u00f0 um 24%. Komum \u00e1 br\u00e1\u00f0am\u00f3tt\u00f6ku barna vegna lungnab\u00f3lgu hefur f\u00e6kka\u00f0 um 23% og innl\u00f6gnum \u00e1 Barnasp\u00edtala Hringsins um 20%. Innl\u00f6gnum vegna \u00edfarandi pneum\u00f3kokka-s\u00fdkinga hefur f\u00e6kka\u00f0 um 93% fr\u00e1 upphafi b\u00f3lusetningarinnar.<\/p>\n

Ranns\u00f3knin s\u00fdnir a\u00f0 sj\u00fakd\u00f3msbyr\u00f0i pneum\u00f3kokka hefur minnka\u00f0 umtalsvert \u00ed \u00edslenskum b\u00f6rnum fr\u00e1 upphafi b\u00f3lusetningar \u00e1ri\u00f0 2011.<\/p>\n

Abstract<\/strong><\/p>\n

Streptococcus pneumonia is a common cause of respiratory tract infections in children and can cause life-threatening invasive infections. Vaccinations against the 10 most common, virulent and\/or antimicrobial resistant serotypes was initiated in Iceland in 2011.<\/p>\n

The aim of this study was to examine the impact of the vaccination on pneumococcal carriage and infections.<\/p>\n

Nasopharyngeal carriage was evaluated annually and health care or hospital visits due to acute otitis media, respiratory infections or invasive disease were measured.<\/p>\n

Nasopharyngeal carriage of vaccine serotypes was reduced (94%). The total carriage rate was unchanged due to replacement with less virulent serotypes. Antimicrobial non-susceptible pneumococci were less common. Health care visits for acute otitis media were reduced (24%) as were visits to paediatric emergency room due to pneumonia (23%) and hospital admissions (20%). Admissions for invasive pneumococcal infections were reduced (93%).<\/p>\n

The burden of pneumococcal disease in Iceland has been greatly reduced following the vaccination.<\/p>\n

Um doktorsefni\u00f0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><\/p>\n

Sam\u00fael Sigur\u00f0sson er f\u00e6ddur \u00e1 \u00cdsafir\u00f0i 25. jan\u00faar 1988. Hann lauk st\u00fadentspr\u00f3fi fr\u00e1 Menntask\u00f3lanum vi\u00f0 Hamrahl\u00ed\u00f0 2007, B.Sc.-pr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i 2013 fr\u00e1 H\u00e1sk\u00f3la \u00cdslands og kand\u00eddatspr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 sama sk\u00f3la 2017. Sam\u00fael starfar n\u00fa sem l\u00e6knakand\u00eddat \u00e1 Landsp\u00edtala. Foreldrar Sam\u00faels eru Deborah \u00d3lafsson og Sigur\u00f0ur \u00d3lafsson. Samb\u00fdliskona Sam\u00faels er Gu\u00f0r\u00fan Mist Gunnarsd\u00f3ttir l\u00e6knir og eiga \u00feau soninn Tristan Storm.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1204,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2018-12-10T13:00:00+00:00","_phd_date_end":"2018-12-10T16:00:00+00:00","_phd_location":"Ver\u00f6ld - H\u00fas Vigd\u00edsar stofu VHV-023","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"\u00c1hrif b\u00f3lusetningar me\u00f0 pr\u00f3tein-tengdu pneum\u00f3kokka b\u00f3luefni \u00e1 pneum\u00f3kokka \u00ed nefkoki og s\u00fdkingar af v\u00f6ldum pneum\u00f3kokka \u00ed \u00edslenskum b\u00f6rnum. 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