{"id":5994,"date":"2026-10-19T09:48:21","date_gmt":"2026-10-19T09:48:21","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-remina-dilixiati\/"},"modified":"2026-10-19T09:48:21","modified_gmt":"2026-10-19T09:48:21","slug":"doktorsvorn-i-lif-og-laeknavisindum-remina-dilixiati","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-remina-dilixiati\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf- og l\u00e6knav\u00edsindum &#8211; Remina Dilixiati"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Remina Dilixiati ver doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>MITF og umritun \u00ed sortu\u00e6xlum &#8211; The role of MITF in regulating transcriptional cell states in melanoma. <\/strong><\/p>\n<p>Andm\u00e6lendur eru dr. Melissa L. Harris, lektor vi\u00f0 H\u00e1sk\u00f3lann \u00ed Alabama, Birmingham, og Sigur\u00f0ur Ingvarsson, pr\u00f3fessor vi\u00f0 Tilraunast\u00f6\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00ed meinafr\u00e6\u00f0i \u00e1 Keldum.<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var dr.Eir\u00edkur Steingr\u00edmsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild. Auk hans s\u00e1tu \u00ed doktorsnefnd \u00feau Arnar P\u00e1lsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild, dr. Erna Magn\u00fasd\u00f3ttir, d\u00f3sent vi\u00f0 L\u00e6knadeild, Lionel Larue, pr\u00f3fessor vi\u00f0 Institut Curie \u00ed Par\u00eds, og \u00de\u00f3runn Rafnar, yfirma\u00f0ur krabbameinsranns\u00f3kna hj\u00e1 \u00cdslenskri erf\u00f0agreiningu.<\/p>\n<p>Dr. Ingibj\u00f6rg Har\u00f0ard\u00f3ttir, pr\u00f3fessor og varaforseti L\u00e6knadeildar, stj\u00f3rnar ath\u00f6fninni.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n<p>Litfrumur (e. melanocytes) eiga uppruna sinn \u00ed taugakambi (e. neural crest) sem forverafrumur sem fj\u00f6lga s\u00e9r og fer\u00f0ast til \u00e1fangasta\u00f0a sinna \u00fear sem \u00fe\u00e6r s\u00e9rh\u00e6fast og mynda litarefni\u00f0 melan\u00edn. Litfrumur geta ummyndast \u00ed \u00e6xlisfrumur og mynda\u00f0 sortu\u00e6xli. Umritunar\u00fe\u00e1tturinn MITF (Microphthalmia-associated transcription factor) er nau\u00f0synlegur fyrir myndun og starfsemi litfruma en er einnig mikilv\u00e6gur fyrir ummyndun \u00feeirra \u00ed sortu\u00e6xli. Hlutverk \u00feess \u00ed \u00fev\u00ed ferli er ekki a\u00f0 fullu lj\u00f3st.<\/p>\n<p>\u00cd ranns\u00f3kninni var MITF geni\u00f0 slegi\u00f0 \u00fat \u00ed sortu\u00e6xlisfrumum me\u00f0 hj\u00e1lp CRISPR-t\u00e6kni og \u00e1hrif \u00e1 heg\u00f0un frumanna og tj\u00e1ningu gena sko\u00f0u\u00f0. \u00cd lj\u00f3s kom a\u00f0 frumur \u00e1n MITF skipta s\u00e9r h\u00e6gar en vi\u00f0mi\u00f0unarfrumur vegna \u00e1hrifa \u00e1 tj\u00e1ningu gena sem eru mikilv\u00e6g fyrir frumuhringinn. Frumurnar h\u00f6f\u00f0u einnig mun minni fareiginleika en vi\u00f0mi\u00f0unarfrumurnar en \u00ed lj\u00f3s kom a\u00f0 \u00feegar MITF vantar eykst tj\u00e1ning gena sem tengjast utanfrumuefni (e. extracellular matrix) og vi\u00f0lo\u00f0un fruma, svo sem paxillin (PAX) og Focal Adhesion Kinase (FAK). \u00deetta \u00fatsk\u00fdrir a\u00f0 hluta til heg\u00f0un frumanna. Auk \u00feessa kom \u00ed lj\u00f3s a\u00f0 gen sem t\u00e1kna fyrir hist\u00f3n umbreytingarens\u00edmunumPRDM7og SETDB2voru mun minna tj\u00e1\u00f0 \u00ed frumum sem skortir MITFen \u00ed vi\u00f0mi\u00f0unarfrumum \u00e1samt me\u00f0fylgjandi breytingum \u00e1 hist\u00f3num og \u00ed tj\u00e1ningu gena. Tap \u00e1 MITF lei\u00f0ir \u00fev\u00ed til \u00feess a\u00f0 frumurnar h\u00e6tta a\u00f0 skipta s\u00e9r en um lei\u00f0 tj\u00e1 \u00fe\u00e6r \u00fdmis utanfrumuefni og vi\u00f0lo\u00f0unarpr\u00f3tein og geta \u00fev\u00ed ekki fer\u00f0ast. \u00c1hrifin sem vi\u00f0 sj\u00e1um eru b\u00e6\u00f0i vegna beinna \u00e1hrifa MITF \u00e1 tj\u00e1ningu gena en einnig vegna \u00e1hrifa \u00e1 tj\u00e1ningu umbreytingarens\u00edma sem aftur hafa \u00e1hrif \u00e1 hist\u00f3n og tj\u00e1ningu gena.<\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong>\u00a0<\/p>\n<p>Remina er f\u00e6dd 5. jan\u00faar \u00e1ri\u00f0 1988 \u00ed borginni Karamay \u00ed XinJiang-h\u00e9ra\u00f0i \u00ed K\u00edna. H\u00fan lauk BS-pr\u00f3fi \u00ed l\u00edft\u00e6kni \u00e1ri\u00f0 2011 fr\u00e1 H\u00e1sk\u00f3lanum \u00ed Camerino \u00e1 \u00cdtal\u00edu og meistarapr\u00f3fi \u00ed l\u00edft\u00e6kni fr\u00e1 sama sk\u00f3la \u00e1ri\u00f0 2012. H\u00fan h\u00f3f doktorsn\u00e1m vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2013. Foreldrar hennar eru Dilshat Memet (fa\u00f0ir) og Risalet Yasen (m\u00f3\u00f0ir). Remina mun halda \u00e1fram ranns\u00f3knum s\u00ednum sem n\u00fddoktor \u00e1 ranns\u00f3knastofu Eir\u00edks Steingr\u00edmssonar.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1200,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-03-15T13:00:00+00:00","_phd_date_end":"2019-03-15T15:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"MITF og umritun \u00ed sortu\u00e6xlum - The role of MITF in regulating transcriptional cell states in melanoma","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_lif_og_laeknavisindum_remina_dilixiati","_phd_source_node_id":"315883","_phd_source_type":"vidburdir","_phd_member_id":195,"footnotes":""},"phd_school":[60,67],"phd_discipline":[70],"class_list":["post-5994","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-heilbrigdisvisindasvid","phd_school-laeknadeild","phd_discipline-phd-i-lif-og-laeknavisindum"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5994","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5994\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1200"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=5994"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=5994"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=5994"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}