{"id":5990,"date":"2026-10-19T09:48:20","date_gmt":"2026-10-19T09:48:20","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-oddur-ingimarsson\/"},"modified":"2026-10-19T09:48:20","modified_gmt":"2026-10-19T09:48:20","slug":"doktorsvorn-i-laeknavisindum-oddur-ingimarsson","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-oddur-ingimarsson\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum &#8211; Oddur Ingimarsson"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Oddur Ingimarsson ver doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>Aukaverkanir ge\u00f0rofslyfja \u2013 g\u00f6gn og gildi til a\u00f0 var\u00f0a\u00a0<\/strong><strong>bestu lei\u00f0ir til notkunar clozapine \u00ed ge\u00f0klofa sem svarar illa me\u00f0fer\u00f0. Adverse drug reactions of antipsychotic drug treatment \u2013 how to balance evidence and values in relation to the use of <\/strong><strong>clozapine in treatment-resistant schizophrenia.<\/strong><\/p>\n<p>Andm\u00e6lendur eru dr. Dan Siskind, d\u00f3sent vi\u00f0 University of Queensland, og dr. Sigur\u00f0ur P\u00e1ll P\u00e1lsson, yfirl\u00e6knir r\u00e9ttar- og \u00f6ryggisge\u00f0l\u00e6kninga vi\u00f0 ge\u00f0svi\u00f0 Landsp\u00edtala.<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var Engilbert Sigur\u00f0sson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Auk hans s\u00e1tu \u00ed doktorsnefnd dr. Halld\u00f3ra J\u00f3nsd\u00f3ttir, dr. Hreinn Stef\u00e1nsson, dr. Magn\u00fas Haraldsson og dr. James H. MacCabe.<\/p>\n<p>Dr. Ingibj\u00f6rg Har\u00f0ard\u00f3ttir, pr\u00f3fessor og varadeildarforseti vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 14.00.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n<p>Um 20-30% sj\u00faklinga me\u00f0 ge\u00f0klofa svara ekki hef\u00f0bundinni me\u00f0fer\u00f0 me\u00f0 ge\u00f0rofslyfjum og eru \u00feeir sag\u00f0ir vera me\u00f0 me\u00f0fer\u00f0ar\u00fer\u00e1an ge\u00f0klofa. Eina me\u00f0fer\u00f0in sem hefur sanna\u00f0 sig sem gagnreynd me\u00f0fer\u00f0 hj\u00e1 \u00feeim h\u00f3pi er ge\u00f0rofslyfi\u00f0 clozap\u00edn.\u00a0 Markmi\u00f0 ranns\u00f3knarinnar var a\u00f0 l\u00fdsa notkun clozap\u00edns \u00e1 \u00cdslandi og aukaverkunum sem tengjast lyfinu og \u00fe\u00e1 s\u00e9rstaklega, kyrningaf\u00e6\u00f0, sykurs\u00fdki t\u00fdpu 2 og bl\u00f3\u00f0fitur\u00f6skun. S\u00ed\u00f0ast en ekki s\u00edst a\u00f0 \u00fer\u00f3a frekar gagnreynda og gildismi\u00f0a\u00f0a me\u00f0fer\u00f0 og sameiginlega \u00e1kvar\u00f0anat\u00f6ku \u00ed langt\u00edma me\u00f0fer\u00f0 me\u00f0fer\u00f0ar\u00fer\u00e1s ge\u00f0klofa.<\/p>\n<p>Ger\u00f0 var textaleit \u00ed sj\u00fakraskr\u00e1 sj\u00faklinga sem h\u00f6f\u00f0u sam\u00feykkt \u00fe\u00e1ttt\u00f6ku \u00ed ranns\u00f3kn \u00e1 erf\u00f0abreytileika og ge\u00f0rofssj\u00fakd\u00f3mum a\u00f0 or\u00f0um sem tengjast clozap\u00ednnotkun og helstu aukaverkunum. Samtals fannst 201 sj\u00faklingur me\u00f0 ge\u00f0klofa \u00fear sem h\u00e6gt var a\u00f0 sta\u00f0festa notkun \u00e1 clozap\u00edni og 410 sj\u00faklingar me\u00f0 ge\u00f0klofa sem h\u00f6f\u00f0u aldrei nota\u00f0 lyfi\u00f0.<\/p>\n<p>Me\u00f0alaldur vi\u00f0 upphaf clozap\u00ednsnotkunar reyndist 37,8 \u00e1r \u00e1 t\u00edmabilinu. Um 71,2% sj\u00faklinga sem h\u00f3fu me\u00f0fer\u00f0 me\u00f0 clozap\u00edni voru enn \u00e1 clozap\u00edn me\u00f0fer\u00f0 20 \u00e1rum s\u00ed\u00f0ar. Enginn munur kom fram \u00e1 t\u00ed\u00f0ni alvarlegrar kyrningaf\u00e6\u00f0ar (kyrningar \u00e1 bilinu 0-1400\/mm3) hj\u00e1 sj\u00faklingum \u00e1 clozap\u00edni og sj\u00faklingum me\u00f0 ge\u00f0klofa sem h\u00f6f\u00f0u aldrei fari\u00f0 \u00e1 clozap\u00edn me\u00f0fer\u00f0. L\u00edklega tengist st\u00f3r hluti af kyrningaf\u00e6\u00f0 hj\u00e1 sj\u00faklingum \u00e1 clozapine ekki clozap\u00ednme\u00f0fer\u00f0.\u00a0 \u00dev\u00ed \u00fearf a\u00f0 \u00edgrunda vel \u00e1kvar\u00f0anir um a\u00f0 h\u00e6tta clozap\u00ednme\u00f0fer\u00f0 einstaklinga me\u00f0 me\u00f0fer\u00f0ar\u00fer\u00e1an ge\u00f0klofa \u00e1 grundvelli mi\u00f0lungs alvarlegrar kyrningaf\u00e6\u00f0ar hafi me\u00f0fer\u00f0 skila\u00f0 g\u00f3\u00f0um \u00e1rangri. Hafa ver\u00f0ur \u00ed huga a\u00f0 almennt er ekki \u00ed bo\u00f0i me\u00f0fer\u00f0 me\u00f0 samb\u00e6rilega virkni. L\u00e6knar \u00feurfa a\u00f0 vera vel vakandi fyrir efnaskiptavillu af v\u00f6ldum clozap\u00edns og \u00fe\u00e1 s\u00e9rstaklega sykurs\u00fdki t\u00fdpu 2 hj\u00e1 konum.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>Oddur Ingimarsson er f\u00e6ddur \u00e1ri\u00f0 1978. Foreldrar hans eru Ingimar J\u00f3hannsson, fyrrverandi skrifstofustj\u00f3ri \u00ed atvinnuvegar\u00e1\u00f0uneyti, og Lill\u00fd Valger\u00f0ur Oddsd\u00f3ttir, fyrrverandi ritari \u00ed R\u00e1\u00f0h\u00fasi Reykjav\u00edkur. Oddur er kv\u00e6ntur Soff\u00edu Sigr\u00ed\u00f0i Valgar\u00f0sd\u00f3ttur, s\u00e9rfr\u00e6\u00f0ingi hj\u00e1 r\u00edkisskattstj\u00f3ra, og eiga \u00feau saman Tinnu Katr\u00ednu 9 \u00e1ra og Ara 7 \u00e1ra. Auk \u00feess \u00e1 Oddur d\u00f3tturina \u00d3l\u00f6fu 15 \u00e1ra.<\/p>\n<p>Oddur lauk emb\u00e6ttispr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i \u00e1ri\u00f0 2005 og MS pr\u00f3fi \u00ed vi\u00f0skiptafr\u00e6\u00f0i vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00feremur \u00e1rum s\u00ed\u00f0ar. Hann lauk s\u00e9rn\u00e1mi \u00ed ge\u00f0l\u00e6kningum \u00e1ri\u00f0 2015 og hefur starfa\u00f0 s\u00ed\u00f0an sem ge\u00f0l\u00e6knir \u00e1 Landsp\u00edtala. \u00c1\u00f0ur starfa\u00f0i Oddur sem l\u00e6knir \u00e1 sj\u00fakrah\u00fasinu Vogi, sem s\u00e9rfr\u00e6\u00f0ingur hj\u00e1 Landsbankanum, vi\u00f0 hugb\u00fana\u00f0ar\u00fer\u00f3un hj\u00e1 CIS-Theriak og sem forma\u00f0ur stj\u00f3rnar Almenna l\u00edfeyrissj\u00f3\u00f0sins.\u00a0<\/p>\n<\/div><\/div>","protected":false},"featured_media":1192,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2018-04-10T14:00:00+00:00","_phd_date_end":"2018-04-10T16:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Aukaverkanir ge\u00f0rofslyfja \u2013 g\u00f6gn og gildi til a\u00f0 var\u00f0a bestu lei\u00f0ir til notkunar clozapine \u00ed ge\u00f0klofa sem svarar illa me\u00f0fer\u00f0. 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