{"id":5973,"date":"2026-10-19T09:48:16","date_gmt":"2026-10-19T09:48:16","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-erika-morera-mojonero\/"},"modified":"2026-10-19T09:48:16","modified_gmt":"2026-10-19T09:48:16","slug":"doktorsvorn-i-lif-og-laeknavisindum-erika-morera-mojonero","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-erika-morera-mojonero\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf og l\u00e6knav\u00edsindum &#8211; Erika Morera Mojonero"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Mi\u00f0vikudaginn 2. desember ver Erika Morera Mojonero doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>Samskipti milli frumul\u00edna me\u00f0 \u00f3l\u00edkan EMT pr\u00f3f\u00edl og \u00e6\u00f0a\u00feelsfruma \u00ed fram\u00fer\u00f3un brj\u00f3stakrabbameins. Crosstalk between isogenic cells with different EMT profiles and endothelial cells in breast cancer progression.<\/strong><\/p>\n<p><strong>V\u00f6rninni ver\u00f0ur streymt: <\/strong><a href=\"https:\/\/livestream.com\/hi\/doktorsvornerikamoreramojonero\"><strong>https:\/\/livestream.com\/hi\/doktorsvornerikamoreramojonero<\/strong><\/a><\/p>\n<p>Andm\u00e6lendur eru dr. Ren\u00e9 Villadsen, d\u00f3sent \u00ed vefjafr\u00e6\u00f0i vi\u00f0 Kaupmannahafnar-h\u00e1sk\u00f3la og Dr. Helga M. \u00d6gmundsd\u00f3ttir, pr\u00f3fessor emeritus vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var \u00de\u00f3rarinn Gu\u00f0j\u00f3nsson, pr\u00f3fessor og me\u00f0lei\u00f0beinendur voru Gunnhildur \u00c1. Traustad\u00f3ttir, n\u00fddoktor og S\u00e6var Ing\u00fe\u00f3rsson, lektor.<\/p>\n<p>A\u00f0rir \u00ed doktorsnefnd voru: Bjarni A. Agnarsson, pr\u00f3fessor og J\u00f3n \u00de\u00f3r Berg\u00fe\u00f3rsson, lektor.<\/p>\n<p>Engilbert Sigur\u00f0sson, pr\u00f3fessor og deildarforseti L\u00e6knadeildar H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 12:00.<\/p>\n<p><strong>Fj\u00f6ldatakm\u00f6rkun: Einungis 10 manns geta veri\u00f0 \u00ed salnum \u00e1 me\u00f0an dokorsv\u00f6rninni stendur.<\/strong><\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n<p>Bandvefsumbreyting \u00feekjufrumna (e. epithelial to mesenchymal transition (EMT)) er \u00feroskunarfr\u00e6\u00f0ilegur ferill sem kemur fyrir \u00ed sj\u00fakd\u00f3mum eins og trefjun (e. fibrosis) og krabbameini. \u00cd krabbameini hefur EMT veri\u00f0 tengt vi\u00f0 \u00edfarandi \u00e6xlisv\u00f6xt og meinvarpamyndun og er ferillinn almennt tengdur sl\u00e6mum batahorfum. \u00cd \u00feessari ranns\u00f3kn bar \u00e9g saman mun \u00e1 svipger\u00f0 (e. phenotypic) og virkni (e. functional) tveggja frumul\u00edna me\u00f0 sama genet\u00edska bakgrunn (e. isogenic) sem s\u00fdna mismunandi EMT pr\u00f3f\u00edl, D492M og D492HER2. \u00deessar frumul\u00ednur eru komnar fr\u00e1 D492, brj\u00f3st\u00feekjufrumul\u00ednu me\u00f0 stofnfrumueiginleika sem getur mynda\u00f0 b\u00e6\u00f0i kirtil\u00feekju- og v\u00f6\u00f0va\u00feekjufrumur, og \u00ed \u00fer\u00edv\u00ed\u00f0ri r\u00e6kt myndar h\u00fan grein\u00f3tta formger\u00f0.<\/p>\n<p>\u00cd samr\u00e6kt me\u00f0 \u00e6\u00f0a\u00feeli, undirgekkst D492 frumul\u00ednan EMT og vi\u00f0 \u00fea\u00f0 mynda\u00f0ist D492M. D492HER2 var hins vegar myndu\u00f0 me\u00f0 yfirtj\u00e1ningu \u00e1 HER2 krabbameinsgeninu. Svipger\u00f0 D492M frumul\u00ednunnar me\u00f0 tilliti til EMT er lengra komin (e. fixed EMT phenotype) mi\u00f0a\u00f0 vi\u00f0 D492HER2 (e. intermediate EMT phenotype). Ennfremur eru D492M og D492HER2 mismunandi hva\u00f0 var\u00f0ar eiginleika til a\u00f0 mynda \u00e6xli \u00ed m\u00fasum, \u00fea\u00f0 er a\u00f0 segja D492M myndar ekki \u00e6xli \u00e1 me\u00f0an D492HER2 myndar \u00e6xli. Markmi\u00f0 \u00feessarar ranns\u00f3knar var a\u00f0 greina mun \u00ed tj\u00e1ningu gena \u00e1 milli \u00feessara frumul\u00edna og sko\u00f0a mismun \u00ed samskiptum \u00feeirra vi\u00f0 \u00e6\u00f0a\u00feel og sto\u00f0vef. \u00deessi ranns\u00f3kn hefur leitt af s\u00e9r greiningu m\u00f6gulegra krabbameinsgena (e. potential oncogenes) og mat \u00e1 \u00e1hrifum \u00feeirra \u00e1 frumusvipger\u00f0 og \u00e6\u00f0amyndun \u00ed \u00e6\u00f0a\u00feelsfrumum. YKL-40 og ECM1 geta veitt D492HER2 aukna \u00e1r\u00e1sargirni sem sty\u00f0ur framr\u00e1s krabbameins.<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>Epithelial to mesenchymal transition (EMT) is a developmental trait that is hijacked in some disease conditions such as fibrosis and cancer. In cancer, EMT has been linked to increased invasion and metastasis, and is generally associated with a poor prognosis. In this study, I have compared phenotypic and functional differences between two isogenic cell lines exhibiting an EMT profile, D492M and D492HER2, but to a distinct extent. These cell lines are derived from D492, a breast epithelial cell line with stem cell properties that can generate both luminal and myoepithelial cells, and in 3D culture, it forms branching terminal ductal lobular units (TDLU)-like structures.<\/p>\n<p>When co-cultured with breast endothelial cells, D492 undergoes EMT, which is the origin of the D492M subline. Another subline of D492 was generated by overexpressing the HER2 oncogene. D492M has a more fixed EMT phenotype while D492HER2 expresses a more intermediate EMT phenotype. Moreover, D492M and D492HER2 differ in their tumorigenicity, that is, they are non-tumorigenic and tumorigenic, respectively. This study aimed to analyze the expression profile of these cell lines and study how they interact with endothelial cells. This study has prompted the identification of potential oncogenes, YKL-40 and ECM1, and the evaluation of their effects on the cellular phenotype and angiogenic potential in endothelial cells. YKL-40 and ECM1 may provide D492HER2 with increased aggressiveness that supports cancer progression.<\/p>\n<p><strong>Um doktorsefni\u00f0 (in English below)<\/strong><\/p>\n<p>Erika Morera Mojonero er f\u00e6dd \u00ed Bilbao \u00e1 Sp\u00e1ni 8. september 1985. Erika lauk B.Sc. pr\u00f3fi \u00ed l\u00edffr\u00e6\u00f0i fr\u00e1 Complutense H\u00e1sk\u00f3lanum \u00ed Madr\u00edd (UCM) og H\u00e1sk\u00f3lanum \u00ed Amsterdam (UvA) \u00e1ri\u00f0 2010 og starfa\u00f0i s\u00ed\u00f0an vi\u00f0 Sanquin bl\u00f3\u00f0bankann \u00ed Amsterdam \u00fear sem h\u00fan vann a\u00f0 ranns\u00f3knaverkefni um hlutverk pr\u00edon pr\u00f3teins (PrP) \u00ed vi\u00f0lo\u00f0un og skri\u00f0i \u00e6\u00f0a\u00feelsfruma. Erika lauk M.Sc. pr\u00f3fi \u00ed frumul\u00edffr\u00e6\u00f0i og erf\u00f0afr\u00e6\u00f0i fr\u00e1 Aut\u00f3noma H\u00e1sk\u00f3lanum \u00ed Madr\u00edd (UAM) og (UCM) \u00e1ri\u00f0 2013. H\u00fan flutti til \u00cdslands \u00e1ri\u00f0 2015 \u00fear sem h\u00fan hefur unni\u00f0 a\u00f0 doktorsn\u00e1mi s\u00ednu \u00ed H\u00e1sk\u00f3la \u00cdslands (HI). \u00cd dag starfar Erika \u00e1 s\u00fdkla- og veirufr\u00e6\u00f0ideild Landsp\u00edtala \u00cdslands vi\u00f0 greiningu s\u00fdna fyrir veirunni sem veldur COVID-19 \u00ed samstarfi vi\u00f0 \u00cdslenska Erf\u00f0agreiningu. Foreldrar Eriku eru Miguel Morera Escarmena og To\u00f1i Mojonero Jara\u00edz.<\/p>\n<p>***<\/p>\n<p>Erika Morera Mojonero was born in Bilbao, Spain, on the 8th of September 1985. She moved to Madrid as a child and later she conducted her Bachelor\u2019s in Biology at the Complutense University of Madrid (UCM). She finished her studies at the University of Amsterdam (UvA) in 2010. Afterward, she worked at the Blood Bank foundation of Sanquin developing a scientific research project about the role of the prion protein (PrP) in adhesion and migration in vascular cells. In 2013, she conducted her Master\u2019s in Cell Biology and Genetics at the Aut\u00f3noma University of Madrid (UAM) and the UCM. In 2015, she moved to Iceland where she has conducted her Ph.D. studies at the University of Iceland (HI). She is currently working for the Virology Department of Landspitali on the COVID-19 screening and analysis of samples in collaboration with DeCode Genetics. Erika\u2019s parents are Miguel Morera Escarmena and To\u00f1i Mojonero Jara\u00edz.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1142,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2020-12-02T12:00:00+00:00","_phd_date_end":"2020-12-02T15:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Samskipti milli frumul\u00edna me\u00f0 \u00f3l\u00edkan EMT pr\u00f3f\u00edl og \u00e6\u00f0a\u00feelsfruma \u00ed fram\u00fer\u00f3un brj\u00f3stakrabbameins. 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