{"id":5966,"date":"2026-10-19T09:48:15","date_gmt":"2026-10-19T09:48:15","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-asa-bryndis-gudmundsdottir\/"},"modified":"2026-10-19T09:48:15","modified_gmt":"2026-10-19T09:48:15","slug":"doktorsvorn-i-lif-og-laeknavisindum-asa-bryndis-gudmundsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lif-og-laeknavisindum-asa-bryndis-gudmundsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00edf- og l\u00e6knav\u00edsindum – \u00c1sa Brynd\u00eds Gu\u00f0mundsd\u00f3ttir"},"content":{"rendered":"
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\u00deri\u00f0judaginn 4. j\u00fan\u00ed ver \u00c1sa Brynd\u00eds Gu\u00f0mundsd\u00f3ttir doktorsritger\u00f0 s\u00edna \u00ed l\u00edf- og l\u00e6kna-v\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: \u00c1hrif utanfrumufj\u00f6lsykra Cyanobacterium aponinum \u00far Bl\u00e1a L\u00f3ninu \u00e1 \u00f3n\u00e6missv\u00f6r in vitro. Effects of exopolysaccharides from Cyanobacterium aponinum from the Blue Lagoon in Iceland on immune responses in vitro.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. Anna Smed S\u00f6rensen, d\u00f3sent vi\u00f0 Karolinska H\u00e1sk\u00f3lann \u00ed Sv\u00ed\u00fej\u00f3\u00f0, og<\/p>\n

Kristj\u00e1n Erlendsson, d\u00f3sent vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Umsj\u00f3narkennari var dr. J\u00f3na Freysd\u00f3ttir, pr\u00f3fessor vi\u00f0 L\u00e6knadeild, og lei\u00f0beinandi var dr. Ingibj\u00f6rg Har\u00f0ard\u00f3ttir, pr\u00f3fessor vi\u00f0 L\u00e6knadeild.<\/p>\n

Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd dr. Bj\u00f6rn R\u00fanar L\u00fa\u00f0v\u00edksson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild og forst\u00f6\u00f0uma\u00f0ur \u00d3n\u00e6misfr\u00e6\u00f0ideildar Landsp\u00edtala, El\u00edn Soff\u00eda \u00d3lafsd\u00f3ttir, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild, og Gu\u00f0mundur Hrafn Gu\u00f0mundsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild.<\/p>\n

Dr. Engilbert Sigur\u00f0sson, pr\u00f3fessor og forseti L\u00e6knadeildar H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed H\u00e1t\u00ed\u00f0asal H\u00e1sk\u00f3la \u00cdslands og hefst kl. 9:00.<\/p>\n

\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n

L\u00e6kningam\u00e1ttur Bl\u00e1a L\u00f3nsins var uppg\u00f6tva\u00f0ur af s\u00f3rasj\u00faklingum sk\u00f6mmu eftir myndun \u00feess og hafa j\u00e1kv\u00e6\u00f0 \u00e1hrif b\u00f6\u00f0unar \u00ed l\u00f3ninu veri\u00f0 sta\u00f0fest \u00ed kl\u00edn\u00edskum ranns\u00f3knum. Enn fremur hefur veri\u00f0 s\u00fdnt a\u00f0 b\u00f6\u00f0un \u00ed l\u00f3ninu samhli\u00f0a lj\u00f3same\u00f0fer\u00f0 s\u00e9 \u00e1rangursr\u00edkari en lj\u00f3same\u00f0fer\u00f0 ein og s\u00e9r. \u00der\u00e1tt fyrir vins\u00e6ldir l\u00f3nsins er l\u00edti\u00f0 vita\u00f0 um hvernig \u00fea\u00f0 hefur \u00e1hrif \u00e1 s\u00f3ra. Bl\u00e1gr\u00e6n\u00fe\u00f6rungurinn Cyanobacterium aponinum er r\u00edkjandi l\u00edfvera \u00ed jar\u00f0sj\u00f3 Bl\u00e1a L\u00f3nsins og framlei\u00f0ir hann utanfrumufj\u00f6lsykru (EPS-Ca) sem hann seytir \u00fat \u00ed umhverfi sitt. Tilgangur verkefnisins var a\u00f0 kanna verkun og verkunarm\u00e1ta EPS-Ca \u00ed frumum sem taka \u00fe\u00e1tt \u00ed meinger\u00f0 s\u00f3ra.<\/p>\n

Ni\u00f0urst\u00f6\u00f0ur ranns\u00f3knarinnar s\u00fdna a\u00f0 EPS-Ca breytir svipger\u00f0 angafrumna \u00ed b\u00e6li-angafrumur sem stu\u00f0la a\u00f0 s\u00e9rh\u00e6fingu T frumna yfir \u00ed T b\u00e6lifrumur. Einnig dregur EPS-Ca \u00far bo\u00f0efnaseytun og r\u00e6singu \u00f6rva\u00f0ra T frumna. EPS-Ca g\u00e6ti \u00fev\u00ed dregi\u00f0 \u00far r\u00e6singu og fj\u00f6lda T frumna sem halda til \u00ed h\u00fa\u00f0inni. EPS-Ca minnka\u00f0i einnig seytingu hyrnisfrumna \u00e1 flakkbo\u00f0um sem kalla \u00e1 T frumur til h\u00fa\u00f0arinnar og minnka\u00f0i umritun gens sem tj\u00e1 fyrir pr\u00f3teini sem tali\u00f0 er tengjast meinger\u00f0 s\u00f3ra. EPS-Ca vir\u00f0ist \u00fev\u00ed hafa \u00e1hrif \u00e1 allar lykilfrumurnar sem taka \u00fe\u00e1tt \u00ed meinger\u00f0 s\u00f3ra og vir\u00f0ist \u00e1hrifunum mi\u00f0la\u00f0 me\u00f0 hindrun \u00e1 Dectin-1 vi\u00f0takanum og Syk bo\u00f0lei\u00f0inni. Ni\u00f0urst\u00f6\u00f0urnar benda \u00fev\u00ed til \u00feess a\u00f0 EPS-Ca geti \u00e1tt \u00fe\u00e1tt \u00ed \u00feeim bata sem s\u00f3rasj\u00faklingar f\u00e1 vi\u00f0 b\u00f6\u00f0un \u00ed l\u00f3ninu og lei\u00f0a \u00ed lj\u00f3s me\u00f0 hva\u00f0a lei\u00f0um \u00feeim \u00e1hrifum er m\u00f6gulega mi\u00f0la\u00f0.<\/p>\n

Abstract<\/strong><\/p>\n

Regular bathing in the Blue Lagoon in Iceland has been shown to have beneficial effects on the manifestations of psoriasis in clinical studies. Moreover, bathing in the Blue Lagoon in conjunction with UVB treatment gives better results than UVB treatment alone. How these beneficial effects are mediated is still not known. The cyanobacteria Cyanobacterium aponinum is one of the main organisms found in the Blue Lagoon. It produces an exopolysaccharide (EPS-Ca), which is secreted into the lagoon. The objective of the study was to determine the effects of EPS-Ca on immune responses of cells involved in the pathogenesis of psoriasis and how EPS-Ca mediated its effects.<\/p>\n

The results show that following an in vitro treatment with EPS-Ca, dendritic cells switch their phenotype towards a regulatory one, which has the potential to induce differentiation of T cells into T regulatory cells at the cost of their differentiation into the disease inducing Th17 cells. In addition, EPS-Ca reduced activation of stimulated T cells, and keratinocyte production of inflammatory chemokines. Furthermore, EPS-Ca also reduced keratinocyte expression of the gene encoding for one of the autoantigens for psoriasis. Interestingly, the effects of EPS-Ca seemed to be mediated by influencing Dectin-1 and the Syk signaling pathway in all the cell types studied. These data indicate that EPS-Ca may contribute to the beneficial effects obtained by psoriasis patients by bathing in the Blue Lagoon and suggests a possible mechanism by which EPS-Ca has its effects.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

\u00c1sa Brynd\u00eds Gu\u00f0mundsd\u00f3ttir lyfjafr\u00e6\u00f0ingur er f\u00e6dd \u00e1ri\u00f0 1986. H\u00fan lauk st\u00fadentspr\u00f3fi af n\u00e1tt\u00farufr\u00e6\u00f0ibraut Menntask\u00f3lans \u00ed Reykjav\u00edk \u00e1ri\u00f0 2006, BS-pr\u00f3fi \u00ed lyfjafr\u00e6\u00f0i \u00e1ri\u00f0 2009 og MS-pr\u00f3fi \u00ed lyfjafr\u00e6\u00f0i \u00e1ri\u00f0 2011, fr\u00e1 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands. \u00c1samt ranns\u00f3knum og kennslu fr\u00e1 2011 hefur \u00c1sa Brynd\u00eds unni\u00f0 a\u00f0 doktorsverkefni s\u00ednu \u00ed l\u00edf- og l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00cd fr\u00e1 \u00e1rinu 2014. Foreldrar \u00c1su Brynd\u00edsar eru pr\u00f3fessor Gu\u00f0mundur \u00deorgeirsson hjartal\u00e6knir og Brynd\u00eds Sigurj\u00f3nsd\u00f3ttir sk\u00f3lameistari. Samb\u00fdlisma\u00f0ur \u00c1su Brynd\u00edsar er dr. S\u00e6var Ing\u00fe\u00f3rsson frumul\u00edffr\u00e6\u00f0ingur og eiga \u00feau b\u00f6rnin Bogeyju Sigr\u00ed\u00f0i 11 \u00e1ra og \u00deorgeir Gunnar 5 \u00e1ra.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1118,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-06-04T09:00:00+00:00","_phd_date_end":"2019-06-04T12:00:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"\u00c1hrif utanfrumufj\u00f6lsykra Cyanobacterium aponinum \u00far Bl\u00e1a L\u00f3ninu \u00e1 \u00f3n\u00e6missv\u00f6r in vitro. 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