{"id":5964,"date":"2026-10-19T09:48:15","date_gmt":"2026-10-19T09:48:15","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-laeknavisindum-andri-leo-lemarquis\/"},"modified":"2026-10-19T09:48:15","modified_gmt":"2026-10-19T09:48:15","slug":"doktorsvorn-i-laeknavisindum-andri-leo-lemarquis","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-laeknavisindum-andri-leo-lemarquis\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed l\u00e6knav\u00edsindum &#8211; Andri Le\u00f3 Lemarquis"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Andri Le\u00f3 Lemarquis ver doktorsritger\u00f0 s\u00edna \u00ed l\u00e6knav\u00edsindum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>Clinical, cellular and serologic analysis of selective IgA deficiency. Kl\u00edn\u00edsk mynd og \u00f3n\u00e6missvar einstaklinga me\u00f0 s\u00e9rt\u00e6kan IgA skort.<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>Andm\u00e6lendur eru dr. Rita Carsetti, pr\u00f3fessor vi\u00f0 Ospedale Pediatrico Bambino \u00ed R\u00f3m, og dr. Valt\u00fdr Stef\u00e1nsson Thors, a\u00f0junkt \u00ed barnal\u00e6kningum vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n<p>\u00a0<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var dr. Bj\u00f6rn R\u00fanar L\u00fa\u00f0v\u00edksson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild, og me\u00f0lei\u00f0beinandi var dr. Una Bjarnad\u00f3ttir, l\u00edfefnafr\u00e6\u00f0ingur.<\/p>\n<p>Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd dr. \u00c1sgeir Haraldsson og dr. Ingileif J\u00f3nsd\u00f3ttir, pr\u00f3fessorar vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands, \u00e1samt dr. Ren\u00e9 Toes, pr\u00f3fessor vi\u00f0 Leiden University Medical Center \u00ed Hollandi.<\/p>\n<p>\u00a0<\/p>\n<p>Dr. Ingibj\u00f6rg Har\u00f0ard\u00f3ttir, pr\u00f3fessor og varaforseti L\u00e6knadeildar H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni.<\/p>\n<p>\u00a0<\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n<p>Markmi\u00f0 ranns\u00f3knarinnar var a\u00f0 greina kl\u00edn\u00edska og \u00f3n\u00e6misfr\u00e6\u00f0ilega mynd s\u00e9rt\u00e6ks IgA skorts (sIgAD). Notast var vi\u00f0 kl\u00edn\u00edska greiningu, frumugreiningu eitilfrumna, sj\u00e1lfs\u00f3n\u00e6mism\u00f3tefna-m\u00e6lingu og bo\u00f0efnam\u00e6lingar til betri skilgreiningar \u00e1 einstaklingum me\u00f0 gallann. Hj\u00e1 sIgAD einstaklingum er h\u00e1 t\u00ed\u00f0ni sj\u00e1lfs\u00f3n\u00e6mis, ofn\u00e6missj\u00fakd\u00f3ma og s\u00fdkinga. Sermism\u00e6lingar s\u00fdna fram \u00e1 ofseytingu vissra \u00f3n\u00e6mis\u00fe\u00e1tta sem tengjast B frumu\u00feroskun. \u00de\u00e6ttirnir a\u00f0greina sIgAD einstaklinga fr\u00e1 heilbrig\u00f0um og vir\u00f0ast einnig tengjast sj\u00e1lfs\u00f3n\u00e6mismyndun. Frumugreining einstaklinga bendir til st\u00f6\u00f0gunar snemma \u00ed B frumu\u00feroska. Hins vegar hafa \u00feeir e\u00f0lilegar T frumur hva\u00f0 var\u00f0ar fj\u00f6lda og virkni. \u00d6rvun me\u00f0 T frumu \u00f3h\u00e1\u00f0u svari B frumna er galla\u00f0, en \u00fea\u00f0 er mikilv\u00e6gt \u00ed sl\u00edmh\u00fa\u00f0um \u00fear sem IgA er hva\u00f0 mikilv\u00e6gast. Fyrir utan l\u00e6kka\u00f0a IL-21 sv\u00f6run B frumna um pSTAT3 bo\u00f0lei\u00f0ina eru innanfrumubor\u00f0ferlar einstaklinganna a\u00f0 mestu e\u00f0lilegir. mRNA tj\u00e1ning einstaklinganna bendir til vanvirkrar sv\u00f6runar sem tengist r\u00f6skun \u00ed \u00feroskun fr\u00e1 \u00f3\u00ferosku\u00f0um B frumum til s\u00ed\u00f0ari \u00feroskunarstiga. Ni\u00f0urst\u00f6\u00f0urnar benda til vanst\u00fdringar \u00f3n\u00e6missvars B frumna \u00e1n T frumugalla. \u00deetta vir\u00f0ist m\u00f6gulega tengjast h\u00e1rri seytingu \u00f3n\u00e6mis\u00fe\u00e1tta sem tali\u00f0 er a\u00f0 lei\u00f0i til ofvirkni \u00f3n\u00e6missvars og aukinnar byr\u00f0i ofn\u00e6mis og \u00f3n\u00e6missj\u00fakd\u00f3ma. Meginni\u00f0urst\u00f6\u00f0ur ranns\u00f3knarinnar eru \u00fev\u00ed a\u00f0 \u00ed s\u00e9rt\u00e6kum IgA skorti er tenging milli kl\u00edn\u00edskrar myndar sj\u00e1lfs\u00f3n\u00e6mis, s\u00fdkinga, ofn\u00e6missj\u00fakd\u00f3ma og r\u00f6skunar \u00f3n\u00e6missvars er tengist B frumu\u00feroskun me\u00f0 tilheyrandi ofseytingu \u00f3n\u00e6mis\u00fe\u00e1tta og sj\u00e1lfs\u00f3n\u00e6mism\u00f3tefnaseytingu. \u00deessir \u00fe\u00e6ttir \u00fearfnast frekari ranns\u00f3kna en g\u00e6tu or\u00f0i\u00f0 a\u00f0 gagni vi\u00f0 greiningu og einstaklingsmi\u00f0a\u00f0ri me\u00f0fer\u00f0 einstaklinga me\u00f0 m\u00f3tefnagalla og \u00f3n\u00e6mistengda sj\u00fakd\u00f3ma.<\/p>\n<p>\u00a0<\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>The aim of the research project\u00a0was to decipher the cellular, serologic and clinical phenotypic specificities of selective IgA deficiency (sIgAD). The research reveals that the defect is associated with an increased risk of diseases related to immune dysregulation such as autoimmunity, atopy and infections, especially the respiratory tract. The serologic analysis of individuals with sIgAD reveals a high autoantibody positivity with high serum concentrations of immune factors related to inflammation. Interestingly these factors cluster together and may be interconnected with autoantibody positivity. The cellular characterisation reveals a defect limited to early developmental stages of B cells. The IgA production defect is not only limited to T cell dependent stimulations but is also seen after T cell independent stimulations. While multiple B cell stimuli have been shown to lead to faulty IgA production, only a lower signalling in STAT3 was seen after IL-21 stimulation. Finally, the transcriptomic signatures of sIgAD B cells seen after CpG stimulation revealed big differences in transcription after stimulation that may be linked by to defects in B cell development. Collectively our data shows a serologically classified disease with immune morbidities that has an early B cell developmental problem, a dysregulated serological profile related to autoantibody production and a transcriptomic signature associated with early B cell dysregulation. These may be of value in the prediction of immune burden in PADs with a possibility for the development of personalised treatment options.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>Andri Le\u00f3 Lemarquis er f\u00e6ddur \u00ed Reykjav\u00edk \u00e1ri\u00f0 1989. Hann lauk st\u00fadentspr\u00f3fi af n\u00e1tt\u00farufr\u00e6\u00f0i- og m\u00e1labraut fr\u00e1 Menntask\u00f3lanum vi\u00f0 Hamrahl\u00ed\u00f0 2009 og BS-pr\u00f3fi \u00ed l\u00e6knisfr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00feremur \u00e1rum s\u00ed\u00f0ar. Andri Le\u00f3 h\u00f3f doktorsn\u00e1m samhli\u00f0a kand\u00eddatsn\u00e1mi \u00ed l\u00e6knisfr\u00e6\u00f0i \u00e1ri\u00f0 2013 undir handlei\u00f0slu Bj\u00f6rns R\u00fanars L\u00fa\u00f0v\u00edkssonar pr\u00f3fessors. Veturinn 2014-2015 f\u00e9kk Andri Le\u00f3 short term fellowship fr\u00e1 EMBO samt\u00f6kunum til a\u00f0 stunda ranns\u00f3knir undir handlei\u00f0slu pr\u00f3fessors Rene E. M. Toes, vi\u00f0 Leiden University Medical Center \u00ed Hollandi. Auk \u00feessa hefur Andri unni\u00f0 a\u00f0 skrifum og erf\u00f0agreiningu undir handlei\u00f0slu pr\u00f3fessors Olovs Ekwall vi\u00f0 Sahlgrenska sj\u00fakrah\u00fasi\u00f0 \u00ed Sv\u00ed\u00fej\u00f3\u00f0 veturinn 2018-2019. \u00dear heldur hann \u00e1fram ranns\u00f3knum \u00ed \u00f3n\u00e6misfr\u00e6\u00f0i samhli\u00f0a s\u00e9rn\u00e1mi.<\/p>\n<p>Andri Le\u00f3 \u00fatskrifa\u00f0ist sem l\u00e6knir \u00ed desember 2015 og lauk kand\u00eddatsn\u00e1mi \u00ed jan\u00faar 2017. Hann hefur unni\u00f0 sem deildarl\u00e6knir vi\u00f0 Landsp\u00edtalann en er n\u00fa b\u00fasettur \u00ed Sv\u00ed\u00fej\u00f3\u00f0 \u00fear sem hann s\u00e9rh\u00e6fir sig \u00ed barnal\u00e6knisfr\u00e6\u00f0i vi\u00f0 Sahlgrenska sj\u00fakrah\u00fasi\u00f0.<\/p>\n<p>Andri var valinn Ungur v\u00edsindama\u00f0ur Landsp\u00edtalans \u00e1ri\u00f0 2016, hefur fengi\u00f0 fj\u00f6lda styrkja og kynnt ranns\u00f3knir s\u00ednar \u00e1 al\u00fej\u00f3\u00f0legum r\u00e1\u00f0stefnum, sem og innanlands. Samhli\u00f0a doktorsn\u00e1mi hefur Andri Le\u00f3 lei\u00f0beint b\u00e6\u00f0i BSc- og MSc-nemum og kennt sem stundakennari vi\u00f0 H\u00e1sk\u00f3la \u00cdslands.<\/p>\n<p>Foreldrar Andra Le\u00f3 eru G\u00e9rard Lemarquis kennari, og Mar\u00eda Sigr\u00ed\u00f0ur Gunnarsd\u00f3ttir b\u00f3kasafnsfr\u00e6\u00f0ingur. Samb\u00fdliskona Andra er Una Sigtryggsd\u00f3ttir myndlistarma\u00f0ur og eiga \u00feau b\u00f6rnin Tristan Emil 7 \u00e1ra og Eleu M\u00edu 2 \u00e1ra.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1115,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-06-03T13:00:00+00:00","_phd_date_end":"2019-06-03T15:30:00+00:00","_phd_location":"A\u00f0albygging H\u00e1t\u00ed\u00f0asalur","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Clinical, cellular and serologic analysis of selective IgA deficiency. 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