{"id":5954,"date":"2026-10-19T09:48:13","date_gmt":"2026-10-19T09:48:13","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-maria-sofia-ramos-da-costa\/"},"modified":"2026-10-19T09:48:13","modified_gmt":"2026-10-19T09:48:13","slug":"doktorsvorn-i-lyfjavisindum-maria-sofia-ramos-da-costa","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-maria-sofia-ramos-da-costa\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed lyfjav\u00edsindum &#8211; Maria Sofia Ramos da Costa"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Maria Sofia Ramos da Costa ver doktorsritger\u00f0 s\u00edna \u00ed lyfjav\u00edsindum vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0: <strong>Uppsetning bakteri\u0301ustofnasafns til lyfja\u00fero\u0301unar me\u00f0 a\u00f0sto\u00f0 MALDI-TOF MS \/ IDBac t\u00e6kni (Creation of Diverse Microbial Libraries for Drug Discovery using MALDI-TOF MS \/ IDBac).<\/strong><\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p>Andm\u00e6lendur erudr. Ryan Seipke, d\u00f3sent vi\u00f0 University of Leeds, og dr. Thomas Ostenfeld Larsen, pro\u0301fessor vi\u00f0 Danmarks Tekniske Universitet (DTU).<\/p>\n<p>Lei\u00f0beinendur voru dr. Sesselja \u00d3marsd\u00f3ttir, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild, og Brian T. Murphy, d\u00f3sent vi\u00f0 University of Illinois, Chicago. Auk \u00feeirra s\u00e1tu \u00ed doktorsnefnd dr. El\u00edn Soff\u00eda \u00d3lafsd\u00f3ttir, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild, dr. \u00d3lafur S. Andr\u00e9sson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild, og dr. Karl G. Kristinsson, pr\u00f3fessor vi\u00f0 L\u00e6knadeild.<\/p>\n<p>Dr. El\u00edn Soff\u00eda \u00d3lafsd\u00f3ttir, pr\u00f3fessor og forseti Lyfjafr\u00e6\u00f0ideildar, stj\u00f3rnar ath\u00f6fninni.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>\u00c1grip af ranns\u00f3kn <\/strong><\/p>\n<p>Jafnvel \u00fe\u00f3 a\u00f0 leit eftir ny\u0301jum sy\u0301klalyfjum u\u0301r na\u0301ttu\u0301runni hafi sta\u00f0i\u00f0 yfir i\u0301 n\u00e6rri heila o\u0308ld, hafa fa\u0301ar ny\u0301jungar liti\u00f0 dagsins ljo\u0301s \u00feegar kemur a\u00f0 so\u0308fnun bakteri\u0301a u\u0301r umhverfinu og uppsetningu sy\u0301nasafna i\u0301 \u00feeim tilgangi a\u00f0 leita lyfjavirkra efna u\u0301r \u00feeim. So\u0308kum einsleitni tegunda og efnaflokka i\u0301 \u00feessum bakteri\u0301uso\u0308fnum hefur reynst erfitt a\u00f0 uppgo\u0308tva ny\u0301 og a\u0301\u00f0ur o\u0301\u00feekkt sy\u0301klahemjandi efnasambo\u0308nd u\u0301r \u00feeim. Markmi\u00f0 \u00feessa verkefnis var a\u00f0 setja upp bakteri\u0301ustofnasafn me\u00f0 la\u0301gmarkssko\u0308run hva\u00f0 var\u00f0ar bakteri\u0301utegundir og innihaldsefni. Bakteri\u0301urnar fengust u\u0301r fjo\u0308lbreyttum sy\u0301num sem safna\u00f0 var u\u0301r na\u0301ttu\u0301runni og ha\u0301hra\u00f0a MALDI-TOF massagreiningara\u00f0fer\u00f0 og li\u0301fupply\u0301singat\u00e6kni (IDBac) var ny\u0301tt til a\u00f0 flokka saman bakteri\u0301uko\u0301lo\u0301ni\u0301ur samkv\u00e6mt tegundaro\u0308\u00f0un og a\u00f0greina \u00fe\u00e6r frekar eftir \u00fevi\u0301 hva\u00f0a na\u0301ttu\u0301ruefni \u00fe\u00e6r framlei\u00f0a in situ. Me\u00f0 \u00feessu mo\u0301ti er h\u00e6gt a\u00f0 la\u0301gmarka \u00feann fjo\u0308lda sem fer inn i\u0301 bakteri\u0301ustofnasy\u0301naso\u0308fn og \u00fear me\u00f0 \u00feann kostna\u00f0 sem fylgir, ha\u0301marka efnafr\u00e6\u00f0ilegan fjo\u0308lbreytileika og la\u0301gmarka upphreinsun a\u0301 efnum og skimun fyrir li\u0301fvirkni. \u00deessi verkferill sy\u0301nir a\u00f0 me\u00f0 \u00fevi\u0301 a\u00f0 u\u0301tbu\u0301a betri sy\u0301naso\u0308fn er mo\u0308gulegt a\u00f0 b\u00e6ta ferilinn vi\u00f0 uppgo\u0308tvun lyfjaefna u\u0301r bakteri\u0301um til muna og stu\u00f0la a\u00f0 markvissari u\u0301tkomu vi\u00f0 skimun sy\u0301nasafnanna.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Abstract<\/strong><\/p>\n<p>In the course of a nearly century-long global effort to discover new bacterial-derived drugs from the environment, there have been few innovations to the way that researchers have collected samples and subsequently created microbial libraries sourced for therapeutic discovery. As a result, it is difficult to discover novel antibiotic scaffolds due to the degree of taxonomic and chemical redundancy that exists in these strain libraries, which has led to a divestment in microbial-based natural product drug discovery.To address the need for creating libraries with minimal taxa and natural products overlap from environmental samples, we developed a high-throughput matrix assisted laser desorption ionization mass spectrometry (MALDI-TOF MS) based bioinformatics pipeline (IDBac) that allows us to readily group bacterial colonies by putative taxonomic identity and further discriminate them based on in situnatural product production. This pipeline minimizes library entries and costs associated with library generation, and maximizes chemical space entering into downstream biological screening efforts.This workflow represents a significant advance toward front-end discovery efforts, thereby removing serendipity from library generation.<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>Um doktorsefni\u00f0<\/strong><\/p>\n<p>Maria Sofia Ramos da Costa lauk BS-pr\u00f3fi \u00ed l\u00edffr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3lanum \u00ed Porto \u00e1ri\u00f0 2009 og meistaragr\u00e1\u00f0u \u00ed umhverfisefnafr\u00e6\u00f0i fr\u00e1 sama sk\u00f3la \u00e1ri\u00f0 2011. \u00c1\u00f0ur en h\u00fan h\u00f3f doktorsn\u00e1m vi\u00f0 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2015, hlaut h\u00fan tvo ranns\u00f3knastyrki og starfa\u00f0i hj\u00e1 CIIMAR (Interdisciplinary Centre of Marine and Environmental Research, Port\u00fagal). Sofia er \u00ed samb\u00fa\u00f0 me\u00f0 unnusta s\u00ednum Bruno Borges.<\/p>\n<\/div><\/div>","protected":false},"featured_media":1093,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-06-21T14:00:00+00:00","_phd_date_end":"2019-06-21T16:30:00+00:00","_phd_location":"Askja Salur 132","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"Uppsetning bakteri\u0301ustofnasafns til lyfja\u00fero\u0301unar me\u00f0 a\u00f0sto\u00f0 MALDI-TOF MS \/ IDBac t\u00e6kni (Creation of Diverse Microbial Libraries for Drug Discovery using MALDI-TOF MS \/ IDBac)","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_lyfjavisindum_maria_sofia_ramos_da_costa","_phd_source_node_id":"322275","_phd_source_type":"vidburdir","_phd_member_id":100,"footnotes":""},"phd_school":[60,64],"phd_discipline":[65],"class_list":["post-5954","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-heilbrigdisvisindasvid","phd_school-lyfjafraedideild","phd_discipline-phd-i-lyfjavisindum"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5954","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5954\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1093"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=5954"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=5954"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=5954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}