{"id":5951,"date":"2026-10-19T09:48:13","date_gmt":"2026-10-19T09:48:13","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-eydis-einarsdottir\/"},"modified":"2026-10-19T09:48:13","modified_gmt":"2026-10-19T09:48:13","slug":"doktorsvorn-i-lyfjavisindum-eydis-einarsdottir","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-eydis-einarsdottir\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed lyfjav\u00edsindum – Eyd\u00eds Einarsd\u00f3ttir"},"content":{"rendered":"
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Eyd\u00eds Einarsd\u00f3ttir ver doktorsritger\u00f0 s\u00edna \u00ed lyfjav\u00edsindum vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Ritger\u00f0in ber heiti\u00f0: Leit a\u00f0 lyfjavirkum efnasamb\u00f6ndum \u00far \u00edslenskum sj\u00e1varhryggleysingjum<\/strong>\u00a0(e. Searching for bioactive secondary metabolites from Icelandic marine invertebrates). <\/em><\/p>\n

Andm\u00e6lendur eru dr. Deniz Tasdemir, pr\u00f3fessor vi\u00f0 Geomar Helmholtz for Ocean Research \u00ed Kiel, \u00de\u00fdskalandi, og Gu\u00f0mundur G. Haraldsson, pr\u00f3fessor vi\u00f0 Raunv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Umsj\u00f3narkennari og a\u00f0allei\u00f0beinandi var dr. Sesselja \u00d3marsd\u00f3ttir, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands, og lei\u00f0beinandi me\u00f0 henni var dr. El\u00edn Soff\u00eda \u00d3lafsd\u00f3ttir, pr\u00f3fessor vi\u00f0 s\u00f6mu deild. A\u00f0 auki s\u00e1tu \u00ed doktorsnefnd dr. Helga M. \u00d6gmundsd\u00f3ttir, pr\u00f3fessor vi\u00f0 L\u00e6knadeild H\u00e1sk\u00f3la \u00cdslands, og \u00a0J\u00f6rundur Svavarsson, pr\u00f3fessor vi\u00f0 L\u00edf- og umhverfisv\u00edsindadeild H\u00e1sk\u00f3la \u00cdslands.<\/p>\n

Dr. H\u00e1kon Hrafn Sigur\u00f0sson, pr\u00f3fessor og forseti Lyfjafr\u00e6\u00f0ideildar H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed sal 132 \u00ed \u00d6skju og hefst kl. 13.00.<\/p>\n

\u00c1grip af ranns\u00f3kn<\/strong><\/p>\n

Lyfjavirk efnasamb\u00f6nd \u00far sj\u00e1varhryggleysingjum hafa vaki\u00f0 \u00e1huga v\u00edsindamanna vegna fj\u00f6lbreytileika efnasambanda sem \u00fear er a\u00f0 finna. M\u00f6rg \u00feessara efna hafa reynst l\u00edfvirk og jafnvel haft notagildi gegn hinum \u00fdmsu sj\u00fakd\u00f3mum.<\/p>\n

Markmi\u00f0 ranns\u00f3knarinnar var a\u00f0 rannsaka hvort \u00edslenskir sj\u00e1varhryggleysingjar hef\u00f0u a\u00f0 geyma n\u00fd l\u00edfvirk efnasamb\u00f6nd sem g\u00e6tu reynst \u00e1hugaver\u00f0 til frekari \u00fer\u00f3unar \u00e1 n\u00fdjum lyfjum.<\/p>\n

\u00c1hersla var l\u00f6g\u00f0 \u00e1 a\u00f0 skima eftir hamlandi \u00e1hrifum misskauta\u00f0ra \u00fardr\u00e1tta \u00e1 brj\u00f3stakrabbameinsfrumur \u00ed r\u00e6kt, auk \u00feess a\u00f0 skima eftir \u00f3n\u00e6mistemprandi \u00e1hrifum \u00e1 angafrumur \u00ed r\u00e6kt, me\u00f0 \u00fev\u00ed a\u00f0 meta \u00e1hrif \u00e1 s\u00e9rh\u00e6fingu angafrumnanna. \u00dardr\u00e6ttir sem s\u00fdndu j\u00e1kv\u00e6\u00f0ar ni\u00f0urst\u00f6\u00f0ur voru \u00fe\u00e1tta\u00f0ir ni\u00f0ur og einangra\u00f0ir \u00ed hrein efnasamb\u00f6nd og efnabyggingar \u00feeirra skilgreindar.<\/p>\n

Ranns\u00f3knir voru ger\u00f0ar \u00e1 efnainnihaldi 28 svampa sem safna\u00f0 var \u00e1 str\u00fdtunum \u00ed Eyjafir\u00f0i og samhli\u00f0a var framkv\u00e6md skimun fyrir hemjandi \u00e1hrifum \u00feeirra \u00e1 krabbameinsfrumur. Efnagreining me\u00f0 v\u00f6kvagreini tengdum massagreini (LC-MS\/MS) og frum\u00fe\u00e1ttargreining (principal component analysis \u2013 PCA) voru nota\u00f0ar til \u00feess a\u00f0 flokka efna\u00fe\u00e6tti \u00ed hverjum \u00fardr\u00e6tti fyrir sig. Ni\u00f0urst\u00f6\u00f0urnar voru s\u00ed\u00f0an bornar saman vi\u00f0 ni\u00f0urst\u00f6\u00f0ur \u00far l\u00edfvirknipr\u00f3funum \u00e1 brj\u00f3stakrabbameinsfrumur. \u00c1tta \u00fardr\u00e6ttir \u00far fimm tegundum svampa (Haliclona rosea, Halichondria sitiens, Halichondria panicea, Myxilla incrustans and Lissodendoryx fragilis<\/em>) reyndust hemja frumulifun meira en 50%.<\/p>\n

\u00dear a\u00f0\u00a0 auki, voru \u00ferj\u00fa n\u00fd\u00a0 efnasamb\u00f6nd einangru\u00f0 \u00far svampinum Myxilla incrustans <\/em>og voru \u00feau nefnd myxillin A, B og C. \u00deessi efni s\u00fdndu \u00f3n\u00e6misst\u00fdrandi \u00e1hrif \u00ed in vitro<\/em> angafrumul\u00edkani.<\/p>\n

Ni\u00f0urst\u00f6\u00f0ur \u00feessarar ranns\u00f3knar eru \u00fe\u00e6r fyrstu sem rannsaka annars stigs efnasamb\u00f6nd \u00far \u00edslenskum sj\u00f3 og benda til \u00feess a\u00f0 \u00edslenskir sj\u00e1varhryggleysingjar og \u00fe\u00e1 s\u00e9rstaklega svampar hafi a\u00f0 geyma \u00e1hugaver\u00f0 efnasamb\u00f6nd sem g\u00e6tu reynst lyfjasprotar framt\u00ed\u00f0arinnar. Hverastr\u00fdturnar \u00ed Eyjafir\u00f0i voru s\u00e9rstakur s\u00f6fnunarsta\u00f0ur \u00ed \u00feessu verkefni.<\/p>\n

Um doktorsefni\u00f0<\/strong><\/p>\n

Eyd\u00eds Einarsd\u00f3ttir lauk BSc-gr\u00e1\u00f0u \u00ed l\u00edfefnafr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2006 og MSc-gr\u00e1\u00f0u \u00ed lyfjav\u00edsindum fr\u00e1 sama sk\u00f3la \u00feremur \u00e1rum s\u00ed\u00f0ar. Eyd\u00eds, sem starfar hj\u00e1 Alvotech, \u00e1 tv\u00f6 b\u00f6rn – \u00feau Agnesi Sj\u00f6fn 15 \u00e1ra og Hrafnkel Loga 11 \u00e1ra.<\/p>\n

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