{"id":5948,"date":"2026-10-19T09:48:13","date_gmt":"2026-10-19T09:48:13","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lyfjafraedi-andre-rodrigues-sa-couto\/"},"modified":"2026-10-19T09:48:13","modified_gmt":"2026-10-19T09:48:13","slug":"doktorsvorn-i-lyfjafraedi-andre-rodrigues-sa-couto","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lyfjafraedi-andre-rodrigues-sa-couto\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed lyfjafr\u00e6\u00f0i &#8211; Andr\u00e9 Rodrigues S\u00e1 Couto"},"content":{"rendered":"<div class=\"field-items\">\n<div class=\"field-item even\" property=\"content:encoded\">\n<p>Andr\u00e9 Rodrigues S\u00e1 Couto ver doktorsritger\u00f0 s\u00edna \u00ed lyfjafr\u00e6\u00f0i vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0:H\u00f3pmyndun s\u00fdkl\u00f3dextr\u00edna og s\u00fdkl\u00f3dextr\u00edn fl\u00e9tta.Assessment of self-aggregation on CD and drug\/CD complexes.<br \/>\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0<\/p>\n<p>Andm\u00e6lendur eru dr. Andrea Mele, pr\u00f3fessor vi\u00f0 Politecnico di Milano, \u00cdtal\u00edu, og dr. Bernard Martel, pr\u00f3fessor vi\u00f0 H\u00e1sk\u00f3lann \u00ed Lille, Frakklandi.<\/p>\n<p>\u00a0<\/p>\n<p>Umsj\u00f3narkennari og lei\u00f0beinandi var dr. \u00deorsteinn Loftsson, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild. A\u00f0 auki s\u00e1tu \u00ed doktorsnefnd dr. H\u00e1kon Hrafn Sigur\u00f0sson, pr\u00f3fessor vi\u00f0 Lyfjafr\u00e6\u00f0ideild, og Patrick Augustijns, pr\u00f3fessor vi\u00f0 KU Leuven, Belg\u00edu.<\/p>\n<p>\u00a0<\/p>\n<p>Dr. El\u00edn Soff\u00eda \u00d3lafsd\u00f3ttir, professor vi\u00f0 Lyfjafr\u00e6\u00f0ideild, stj\u00f3rnar ath\u00f6fninni.<\/p>\n<p>\u00a0<\/p>\n<p>\u00c1grip af ranns\u00f3kn<\/p>\n<p>Doktorsverkefni\u00f0 fjallar um s\u00fdkl\u00f3dextr\u00edn og myndun nan\u00f3agna \u00ed vatnslausnum s\u00fdkl\u00f3dextr\u00edna. S\u00fdkl\u00f3dextr\u00edn eru hringlaga f\u00e1sykrungar sem geta auki\u00f0 leysanleika fitus\u00e6kinna lyfja me\u00f0 myndun vatnsleysanlegra fl\u00e9tta (complexes) \u00fear sem fitus\u00e6knir h\u00f3par lyfjasameinda fara inn \u00ed vatnsf\u00e6lin holr\u00fam s\u00fdkl\u00f3dextr\u00edna. Ranns\u00f3knir s\u00fdna a\u00f0 aukinn vatnsleysanleiki lyfja au\u00f0veldar gj\u00f6f \u00feeirra og b\u00e6tir lyfjame\u00f0fer\u00f0 sj\u00faklinga. N\u00fa \u00feegar innihalda um 40 mismunandi marka\u00f0ssett lyf s\u00fdkl\u00f3dextr\u00edn. S\u00fdkl\u00f3dextr\u00edn og lyfjafl\u00e9ttur \u00feeirra geta h\u00f3pa\u00f0 sig saman og mynda\u00f0 agnir, en myndun sl\u00edkra agna getur haft neikv\u00e6\u00f0 \u00e1hrif vi\u00f0 lyfjaframlei\u00f0slu svo sem vi\u00f0 framlei\u00f0slu \u00e1 stungulyfjum. \u00deverm\u00e1l agnanna getur veri\u00f0 fr\u00e1 \u00f6rf\u00e1um nan\u00f3metrum upp \u00ed nokkra millimetra. Markmi\u00f0 doktorsverkefnisins var a\u00f0 \u00fer\u00f3a a\u00f0fer\u00f0ir til a\u00f0 greina s\u00fdkl\u00f3dextr\u00edn og s\u00fdkl\u00f3dextr\u00edn nan\u00f3agnir, og rannsaka \u00fe\u00e1 \u00fe\u00e6tti sem hafa \u00e1hrif \u00e1 myndun \u00feeirra. Fimm mismunandi a\u00f0fer\u00f0ir voru metnar til a\u00f0 greina s\u00fdkl\u00f3dextr\u00edn (\u00fe.e. \u03b1-s\u00fdkl\u00f3dextr\u00edn [\u03b1CD], \u03b2-s\u00fdkl\u00f3dextr\u00edn [\u03b2CD] og 2-h\u00fddrox\u00fdpr\u00f3p\u00fdl-\u03b2-s\u00fdkl\u00f3dextr\u00edn [HP\u03b2CD]) og s\u00fdkl\u00f3dextr\u00edn nan\u00f3agnir \u00ed vatnslausnum. Flutningur s\u00fdkl\u00f3dextr\u00edna \u00ed gegnum h\u00e1lfgegndr\u00e6par himnur var nota\u00f0ur til a\u00f0 \u00e1kvar\u00f0a h\u00f3punarstyrk (critical aggregation concentration [cac]) s\u00fdkl\u00f3dextr\u00edna. Ranns\u00f3knirnar s\u00fdna a\u00f0 \u03b2CD hefur meiri tilhneigingu til a\u00f0 mynda nan\u00f3agnir en \u03b1CD sem aftur hefur meiri tilhneigingu til a\u00f0 mynda nan\u00f3agnir en HP\u03b2CD. Fl\u00e9ttumyndun s\u00fdkl\u00f3dextr\u00edna hefur \u00e1hrif \u00e1 h\u00f3pun \u00feeirra og cac gildi. Einnig s\u00fdna ranns\u00f3knirnar a\u00f0 \u00e1kve\u00f0in efnasamb\u00f6nd (eins og t.d. \u00fevagefni) geta hamla\u00f0 agnamyndun \u00ed s\u00fdkl\u00f3dextr\u00edn lausnum. Ni\u00f0urst\u00f6\u00f0ur doktorsverkefnisins auka \u00feekkingu okkar \u00e1 myndun nan\u00f3agna \u00ed vatnslausnum s\u00fdkl\u00f3dextr\u00edna, sk\u00fdra myndun \u00feeirra og benda \u00e1 lei\u00f0ir til a\u00f0 koma \u00ed veg fyrir myndun agnanna.\u00a0 Ni\u00f0urst\u00f6\u00f0ur verkefnisins munu einnig n\u00fdtast vi\u00f0 h\u00f6nnun \u00e1 s\u00fdkl\u00f3dextr\u00edn nan\u00f3\u00f6gnum til markbundinna lyfjagjafa (\u00fe.e. targeted drug delivery).<\/p>\n<p>Um doktorsefni\u00f0<\/p>\n<p>Andr\u00e9 Rodrigues S\u00e1 Couto, sem f\u00e6ddur er \u00e1ri\u00f0 1988, lauk MS-gr\u00e1\u00f0u \u00ed lyfjafr\u00e6\u00f0i fr\u00e1 H\u00e1sk\u00f3lanum \u00ed Lissabon \u00e1ri\u00f0 2012 og starfa\u00f0i vi\u00f0 ranns\u00f3knir \u00e1 s\u00fdkl\u00f3dextr\u00edni \u00e1\u00f0ur en hann innrita\u00f0ist \u00ed doktorsn\u00e1m undir handlei\u00f0slu \u00deorsteins Loftssonar vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands \u00e1ri\u00f0 2014.<\/p>\n<p>\u00a0<\/p>\n<\/div><\/div>\n","protected":false},"featured_media":1077,"template":"","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"_phd_date_start":"2019-01-18T13:00:00+00:00","_phd_date_end":"2019-01-18T15:30:00+00:00","_phd_location":"Askja 132","_phd_admission":"A\u00f0gangur \u00f3keypis","_phd_thesis_title":"H\u00f3pmyndun s\u00fdkl\u00f3dextr\u00edna og s\u00fdkl\u00f3dextr\u00edn fl\u00e9tta.Assessment of self-aggregation on CD and drug\/CD complexes","_phd_source_url":"https:\/\/gamli.hi.is\/vidburdir\/doktorsvorn_i_lyfjafraedi_andre_rodrigues_sa_couto","_phd_source_node_id":"314213","_phd_source_type":"vidburdir","_phd_member_id":86,"footnotes":""},"phd_school":[60,64],"phd_discipline":[66],"class_list":["post-5948","phd_defence","type-phd_defence","status-publish","has-post-thumbnail","hentry","phd_school-heilbrigdisvisindasvid","phd_school-lyfjafraedideild","phd_discipline-phd-i-lyfjafraedi"],"_links":{"self":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5948","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence"}],"about":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/types\/phd_defence"}],"version-history":[{"count":0,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_defence\/5948\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media\/1077"}],"wp:attachment":[{"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/media?parent=5948"}],"wp:term":[{"taxonomy":"phd_school","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_school?post=5948"},{"taxonomy":"phd_discipline","embeddable":true,"href":"https:\/\/phd.hi.is\/en\/wp-json\/wp\/v2\/phd_discipline?post=5948"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}