{"id":5946,"date":"2026-10-19T09:48:13","date_gmt":"2026-10-19T09:48:13","guid":{"rendered":"https:\/\/phd.hi.is\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-agnieszka-popielec\/"},"modified":"2026-10-19T09:48:13","modified_gmt":"2026-10-19T09:48:13","slug":"doktorsvorn-i-lyfjavisindum-agnieszka-popielec","status":"publish","type":"phd_defence","link":"https:\/\/phd.hi.is\/en\/doktorsvorn\/doktorsvorn-i-lyfjavisindum-agnieszka-popielec\/","title":{"rendered":"Doktorsv\u00f6rn \u00ed lyfjav\u00edsindum – Agnieszka Popielec"},"content":{"rendered":"
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M\u00e1nudaginn 13. \u00e1g\u00fast ver Agnieszka Popielec doktorsritger\u00f0 s\u00edna \u00ed lyfjav\u00edsindum vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands. Ritger\u00f0in ber heiti\u00f0:<\/strong> \u00c1hrif s\u00fdkl\u00f3dextr\u00edna og s\u00fdkl\u00f3dextr\u00edn nan\u00f3agna \u00e1 st\u00f6\u00f0ugleika \u03b2-laktam lyfja. The impact of cyclodextrins and cyclodextrin based nanoparticles for \u03b2-lactam antibiotic stability.<\/strong><\/p>\n

Andm\u00e6lendur eru dr. Malgorzata Sznitowska, professor, Medical University of Gdansk og dr. Sophie Fourmentin, professor, Universit\u00e9 du Littoral C\u00f4te d’Opale<\/p>\n

Umsj\u00f3narkennari og lei\u00f0beinandi var \u00deorsteinn Loftsson, pr\u00f3fessor vi\u00f0 H\u00e1sk\u00f3la \u00cdslands. Auk hans s\u00e1tu \u00ed doktorsnefnd dr. Konstantina Yannakopoulou, Director of Research, National Center for Scientific Research Demokritos og dr. Margr\u00e9t \u00deorsteinsd\u00f3ttir, d\u00f3sent vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00cd.<\/p>\n

Dr. H\u00e1kon Hrafn Sigur\u00f0sson deildarforseti vi\u00f0 Lyfjafr\u00e6\u00f0ideild H\u00e1sk\u00f3la \u00cdslands, stj\u00f3rnar ath\u00f6fninni sem fer fram \u00ed \u00d6skju, stofu 132, og hefst kl. 13:00.<\/p>\n

\u00c1grip af ranns\u00f3kn <\/strong><\/p>\n

Meginmarkmi\u00f0 ranns\u00f3knarverkefnisins: \u00c1hrif s\u00fdkl\u00f3dextr\u00edna og s\u00fdkl\u00f3dextr\u00edn nan\u00f3agna \u00e1 st\u00f6\u00f0ugleika \u03b2-laktam lyfjaBenz\u00fdlpenicill\u00edn (BP) og meropenem (MP) eru \u03b2-laktam s\u00fdklalyf. Lyfin eru mj\u00f6g \u00f3st\u00f6\u00f0ug \u00ed vatnslausn og hafa l\u00edti\u00f0 a\u00f0gengi fr\u00e1 meltingavegi eftir innt\u00f6ku.\u00a0 \u00deau hafa einnig stuttan l\u00edffr\u00e6\u00f0ilegan helmingunart\u00edma og eru skilin hratt \u00far l\u00edkamanum me\u00f0 virkum \u00fatskilna\u00f0i um n\u00fdrun. Vi\u00f0 h\u00fddr\u00f3l\u00fdsu \u03b2-laktam hringsins hverfa s\u00fdkladrepandi \u00e1hrif \u03b2-laktam lyfja og ni\u00f0urbrotsefnin sem myndast geta valdi\u00f0 ofn\u00e6misvi\u00f0br\u00f6g\u00f0um. S\u00fdkl\u00f3dextr\u00edn (e. cyclodextrins) eru hj\u00e1lparefni sem geta auki\u00f0 st\u00f6\u00f0ugleika lyfja \u00ed vatnslausnum me\u00f0 myndun h\u00fdsilfl\u00e9tta (e. inclusion complexes). Litlar fitus\u00e6knar lyfjasameindir e\u00f0a hlutar st\u00e6rri lyfjasameinda geta sest \u00ed holr\u00fam s\u00fdkl\u00f3dextr\u00ednsameindanna sem \u00feannig verja lyfjasameindirnar gegn \u00fdmsum ytri \u00e1hrifum. \u00cd \u00feessu verkefni voru s\u00fdkl\u00f3dextr\u00edn og nan\u00f3agnir bygg\u00f0ar \u00e1 s\u00fdkl\u00f3dextr\u00ednum nota\u00f0ar til a\u00f0 auka st\u00f6\u00f0ugleika \u03b2-laktam s\u00fdklalyfja. \u00cd upphafi verkefnisins voru \u00e1hrif buffersalta og \u00fdmissa s\u00fdkl\u00f3dextr\u00edna \u00e1 st\u00f6\u00f0ugleika benz\u00fdlpenicill\u00edns ranns\u00f6ku\u00f0. Ni\u00f0urbrotshra\u00f0i lyfsins var \u00e1kvar\u00f0a\u00f0ur \u00e1 pH-bilinu 1,2 til 9,6. \u00d3j\u00f3nu\u00f0 s\u00fdkl\u00f3dextr\u00edn (\u00fe.e. HP\u03b2CD og RM\u03b2CD) dr\u00f3gu \u00far ni\u00f0urbroti lyfsins vi\u00f0 l\u00e1gt pH (\u00fe.e. vi\u00f0 pKa lyfsins sem er 2,7).\u00a0 \u00deau hafa l\u00edtil sem engin \u00e1hrif \u00e1 ni\u00f0urbroti\u00f0 vi\u00f0 pH 7,4 og auka ni\u00f0urbrotshra\u00f0ann vi\u00f0 h\u00e6rra pH. S\u00fdkl\u00f3dextr\u00edn me\u00f0 j\u00e1kv\u00e6\u00f0a hle\u00f0slu (QA\u03b3CD) juku ni\u00f0urbrotshra\u00f0ann. Met\u00fdlering OH-h\u00f3pa \u00e1 s\u00fdkl\u00f3dextr\u00edn-sameindum dregur \u00far hvetjandi \u00e1hrifum \u00feeirra \u00e1 ni\u00f0urbrot benz\u00fdlpenicill\u00edns og ef allir OH-h\u00f3par s\u00fdkl\u00f3dextr\u00edna eru met\u00fdlera\u00f0ir f\u00e1st s\u00fdkl\u00f3dextr\u00ednaflei\u00f0ur sem auka st\u00f6\u00f0ugleika benz\u00fdlpenicill\u00edns. Hvetjandi \u00e1hrif n\u00e1tt\u00farulegra s\u00fdkl\u00f3dextr\u00edna \u00e1 h\u00fddr\u00f3l\u00fdsu bens\u00fdlpenicill\u00edns er vegna fl\u00e9ttumyndunar \u00e1 milli OH-h\u00f3panna \u00e1 s\u00fdkl\u00f3dextr\u00edn-sameindunum og \u03b2-laktam hringsins. 2D-ROESY-NMR ranns\u00f3knir \u00e1 benz\u00fdlpenicill\u00edn\/s\u00fdkl\u00f3dextr\u00edn fl\u00e9ttum (\u00fe.e. BP\/\u03b2CD, BP\/RM\u03b2CD, BP\/Trimeb, BP\/\u03b3CD, BP\/RM\u03b3CD) sk\u00fdr\u00f0u hvernig og hvers vegna s\u00fdkl\u00f3dextr\u00edn-fl\u00e9ttun benz\u00fdlpenicill\u00edns getur \u00ed sumum tilfellum auki\u00f0 st\u00f6\u00f0ugleika lyfsins en ekki \u00ed \u00f6\u00f0rum. Ranns\u00f3knirnar s\u00fdndu einnig a\u00f0 h\u00e6gt er a\u00f0 auka b\u00e6\u00f0i st\u00f6\u00f0ugleika og a\u00f0gengi meropenems me\u00f0 \u00fev\u00ed a\u00f0 koma lyfinu fyrir \u00ed s\u00fdkl\u00f3dextr\u00edn-nan\u00f3\u00f6gnum. Margv\u00edslegum a\u00f0fer\u00f0um (svo sem DLS og NTA greiningu, og UV-VIS og NMR greiningu) var beitt vi\u00f0 ranns\u00f3knir \u00e1 nan\u00f3\u00f6gnum sem myndast sj\u00e1lfkrafa vi\u00f0 bl\u00f6ndun karbox\u00fdmet\u00fdlsellul\u00f3su og \u03b2CD fj\u00f6lli\u00f0a me\u00f0 j\u00e1kv\u00e6\u00f0a hle\u00f0slu (QA\u03b2CDp). Ni\u00f0urst\u00f6\u00f0ur verkefnisins s\u00fdna a\u00f0 h\u00e6gt er a\u00f0 nota s\u00fdkl\u00f3dextr\u00edn og fj\u00f6lli\u00f0ur \u00feeirra til a\u00f0 auka st\u00f6\u00f0ugleika og a\u00f0gengi \u03b2-laktam lyfja.<\/p>\n

Abstract<\/strong><\/p>\n

The overarching aim of the research project \u201e<\/p>\n

Um doktorsefni\u00f0 \u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0\u00a0 <\/strong><\/p>\n

Agnieszka was born in February 1989 in Zamo\u015b\u0107 in Poland. She quickly discovered a passion for biology and chemistry, and she was developing her knowledge in these fields in the biochemical class in the high school in a family city. She started her studies in 2008 at the Faculty of Chemistry at the Maria Curie \u2013 Sk\u0142odowska University (UMCS) in Lublin, Poland where in 2011 she graduated from BSc in chemistry and then in 2013 she graduated from BSc in environmental protection as well as she obtained a master degree in chemistry with specialisation in bioactive compounds and cosmetics.<\/p>\n

She began her doctoral studies in 2014 as an Early Stage Researcher in the subproject within the European-funded research project with acronym CycloN Hit. The CycloN Hit, Marie Curie network, consists of 11 members and 7 associate partners from 9 European countries and the US. In her research, she focused on the stabilization of \u03b2-lactam antibiotics in the aqueous media using cyclodextrin.<\/p>\n

Agnieszka is married with Sebastian Popielec, with whom she has two daughters, Joanna and Gabriela, at the age of three.<\/p>\n

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